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Alternatively spliced Robo2 isoforms in zebrafish and rat

Robo2, a member of the robo gene family, functions as a repulsive axon guidance receptor as well as a regulator of cell migration and tissue morphogenesis in different taxa. In this study, a novel isoform of the zebrafish robo2 (robo2_tv2), which included an otherwise alternatively spliced exon (CAE... Full description

Journal Title: Development genes and evolution September 2006, Vol.216(9), pp.555-63
Main Author: Dalkic, Ertugrul
Other Authors: Kuscu, Cem , Sucularli, Ceren , Aydin, Iraz T , Akcali, Kamil C , Konu, Ozlen
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0949-944X ; PMID: 16625395 Version:1
Link: http://pubmed.gov/16625395
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recordid: medline16625395
title: Alternatively spliced Robo2 isoforms in zebrafish and rat
format: Article
creator:
  • Dalkic, Ertugrul
  • Kuscu, Cem
  • Sucularli, Ceren
  • Aydin, Iraz T
  • Akcali, Kamil C
  • Konu, Ozlen
subjects:
  • Alternative Splicing
  • Receptors, Immunologic -- Metabolism
  • Zebrafish -- Embryology
  • Zebrafish Proteins -- Metabolism
ispartof: Development genes and evolution, September 2006, Vol.216(9), pp.555-63
description: Robo2, a member of the robo gene family, functions as a repulsive axon guidance receptor as well as a regulator of cell migration and tissue morphogenesis in different taxa. In this study, a novel isoform of the zebrafish robo2 (robo2_tv2), which included an otherwise alternatively spliced exon (CAE), has been characterized. Robo2_tv2 is expressed differentially in most non-neuronal tissues of adult zebrafish whereas robo2_tv1 expression to a great extent is restricted to the brain and eye. In zebrafish, robo2_tv2 exhibits a very-low-level basal expression starting from 1 day post fertilization until the mid-larval stages, at which time its expression increases dramatically and could be detected throughout adulthood. Our findings demonstrate that the amino acid sequence coded by CAE of the robo2 gene is highly conserved between zebrafish and mammals, and also contains conserved motifs shared with robo1 and robo4 but not with robo3. Furthermore, we provide an account of differential transcription of the CAE homolog in various tissues of the adult rat. These results suggest that the alternatively spliced robo2 isoforms may exhibit tissue specificity.
language: eng
source:
identifier: ISSN: 0949-944X ; PMID: 16625395 Version:1
fulltext: fulltext
issn:
  • 0949944X
  • 0949-944X
url: Link


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titleAlternatively spliced Robo2 isoforms in zebrafish and rat
creatorDalkic, Ertugrul ; Kuscu, Cem ; Sucularli, Ceren ; Aydin, Iraz T ; Akcali, Kamil C ; Konu, Ozlen
ispartofDevelopment genes and evolution, September 2006, Vol.216(9), pp.555-63
identifierISSN: 0949-944X ; PMID: 16625395 Version:1
subjectAlternative Splicing ; Receptors, Immunologic -- Metabolism ; Zebrafish -- Embryology ; Zebrafish Proteins -- Metabolism
descriptionRobo2, a member of the robo gene family, functions as a repulsive axon guidance receptor as well as a regulator of cell migration and tissue morphogenesis in different taxa. In this study, a novel isoform of the zebrafish robo2 (robo2_tv2), which included an otherwise alternatively spliced exon (CAE), has been characterized. Robo2_tv2 is expressed differentially in most non-neuronal tissues of adult zebrafish whereas robo2_tv1 expression to a great extent is restricted to the brain and eye. In zebrafish, robo2_tv2 exhibits a very-low-level basal expression starting from 1 day post fertilization until the mid-larval stages, at which time its expression increases dramatically and could be detected throughout adulthood. Our findings demonstrate that the amino acid sequence coded by CAE of the robo2 gene is highly conserved between zebrafish and mammals, and also contains conserved motifs shared with robo1 and robo4 but not with robo3. Furthermore, we provide an account of differential transcription of the CAE homolog in various tissues of the adult rat. These results suggest that the alternatively spliced robo2 isoforms may exhibit tissue specificity.
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titleAlternatively spliced Robo2 isoforms in zebrafish and rat
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abstractRobo2, a member of the robo gene family, functions as a repulsive axon guidance receptor as well as a regulator of cell migration and tissue morphogenesis in different taxa. In this study, a novel isoform of the zebrafish robo2 (robo2_tv2), which included an otherwise alternatively spliced exon (CAE), has been characterized. Robo2_tv2 is expressed differentially in most non-neuronal tissues of adult zebrafish whereas robo2_tv1 expression to a great extent is restricted to the brain and eye. In zebrafish, robo2_tv2 exhibits a very-low-level basal expression starting from 1 day post fertilization until the mid-larval stages, at which time its expression increases dramatically and could be detected throughout adulthood. Our findings demonstrate that the amino acid sequence coded by CAE of the robo2 gene is highly conserved between zebrafish and mammals, and also contains conserved motifs shared with robo1 and robo4 but not with robo3. Furthermore, we provide an account of differential transcription of the CAE homolog in various tissues of the adult rat. These results suggest that the alternatively spliced robo2 isoforms may exhibit tissue specificity.
pmid16625395
doi10.1007/s00427-006-0070-y
eissn1432041X
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date2006-09