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Fibroblast growth factor-regulated palmitoylation of the neural cell adhesion molecule determines neuronal morphogenesis

During development of the nervous system, short- and long-range signals cooperate to promote axonal growth, guidance, and target innervation. Particularly, a short-range signal transducer, the neural cell adhesion molecule (NCAM), stimulates neurite outgrowth via mechanisms that require posttranslat... Full description

Journal Title: The Journal of neuroscience : the official journal of the Society for Neuroscience 03 September 2008, Vol.28(36), pp.8897-907
Main Author: Ponimaskin, Evgeni
Other Authors: Dityateva, Galina , Ruonala, Mika O , Fukata, Masaki , Fukata, Yuko , Kobe, Fritz , Wouters, Fred S , Delling, Markus , Bredt, David S , Schachner, Melitta , Dityatev, Alexander
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1529-2401 ; PMID: 18768683 Version:1 ; DOI: 10.1523/JNEUROSCI.2171-08.2008
Link: http://pubmed.gov/18768683
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recordid: medline18768683
title: Fibroblast growth factor-regulated palmitoylation of the neural cell adhesion molecule determines neuronal morphogenesis
format: Article
creator:
  • Ponimaskin, Evgeni
  • Dityateva, Galina
  • Ruonala, Mika O
  • Fukata, Masaki
  • Fukata, Yuko
  • Kobe, Fritz
  • Wouters, Fred S
  • Delling, Markus
  • Bredt, David S
  • Schachner, Melitta
  • Dityatev, Alexander
subjects:
  • Fibroblast Growth Factors -- Pharmacology
  • Lipoylation -- Drug Effects
  • Morphogenesis -- Drug Effects
  • Neural Cell Adhesion Molecules -- Metabolism
  • Neurons -- Drug Effects
ispartof: The Journal of neuroscience : the official journal of the Society for Neuroscience, 03 September 2008, Vol.28(36), pp.8897-907
description: During development of the nervous system, short- and long-range signals cooperate to promote axonal growth, guidance, and target innervation. Particularly, a short-range signal transducer, the neural cell adhesion molecule (NCAM), stimulates neurite outgrowth via mechanisms that require posttranslational modification of NCAM and signaling via receptors to a long-range messenger, the fibroblast growth factor (FGF). In the present study we further characterized a mechanism which regulates the functional interplay between NCAM and FGF receptor(s). We show that activation of FGF receptor(s) by FGF2 leads to palmitoylation of the two major transmembrane NCAM isoforms, NCAM140 and NCAM180, translocation of NCAM to GM1 ganglioside-containing lipid rafts, and stimulation of neurite outgrowth of hippocampal neurons. Ablation of NCAM, mutation of NCAM140 or NCAM180 palmitoylation sites, or pharmacological suppression of NCAM signaling inhibited FGF2-stimulated neurite outgrowth. Of the 23 members...
language: eng
source:
identifier: E-ISSN: 1529-2401 ; PMID: 18768683 Version:1 ; DOI: 10.1523/JNEUROSCI.2171-08.2008
fulltext: fulltext
issn:
  • 15292401
  • 1529-2401
url: Link


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titleFibroblast growth factor-regulated palmitoylation of the neural cell adhesion molecule determines neuronal morphogenesis
creatorPonimaskin, Evgeni ; Dityateva, Galina ; Ruonala, Mika O ; Fukata, Masaki ; Fukata, Yuko ; Kobe, Fritz ; Wouters, Fred S ; Delling, Markus ; Bredt, David S ; Schachner, Melitta ; Dityatev, Alexander
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subjectFibroblast Growth Factors -- Pharmacology ; Lipoylation -- Drug Effects ; Morphogenesis -- Drug Effects ; Neural Cell Adhesion Molecules -- Metabolism ; Neurons -- Drug Effects
descriptionDuring development of the nervous system, short- and long-range signals cooperate to promote axonal growth, guidance, and target innervation. Particularly, a short-range signal transducer, the neural cell adhesion molecule (NCAM), stimulates neurite outgrowth via mechanisms that require posttranslational modification of NCAM and signaling via receptors to a long-range messenger, the fibroblast growth factor (FGF). In the present study we further characterized a mechanism which regulates the functional interplay between NCAM and FGF receptor(s). We show that activation of FGF receptor(s) by FGF2 leads to palmitoylation of the two major transmembrane NCAM isoforms, NCAM140 and NCAM180, translocation of NCAM to GM1 ganglioside-containing lipid rafts, and stimulation of neurite outgrowth of hippocampal neurons. Ablation of NCAM, mutation of NCAM140 or NCAM180 palmitoylation sites, or pharmacological suppression of NCAM signaling inhibited FGF2-stimulated neurite outgrowth. Of the 23 members...
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titleFibroblast growth factor-regulated palmitoylation of the neural cell adhesion molecule determines neuronal morphogenesis
descriptionDuring development of the nervous system, short- and long-range signals cooperate to promote axonal growth, guidance, and target innervation. Particularly, a short-range signal transducer, the neural cell adhesion molecule (NCAM), stimulates neurite outgrowth via mechanisms that require posttranslational modification of NCAM and signaling via receptors to a long-range messenger, the fibroblast growth factor (FGF). In the present study we further characterized a mechanism which regulates the functional interplay between NCAM and FGF receptor(s). We show that activation of FGF receptor(s) by FGF2 leads to palmitoylation of the two major transmembrane NCAM isoforms, NCAM140 and NCAM180, translocation of NCAM to GM1 ganglioside-containing lipid rafts, and stimulation of neurite outgrowth of hippocampal neurons. Ablation of NCAM, mutation of NCAM140 or NCAM180 palmitoylation sites, or pharmacological suppression of NCAM signaling inhibited FGF2-stimulated neurite outgrowth. Of the 23 members...
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abstractDuring development of the nervous system, short- and long-range signals cooperate to promote axonal growth, guidance, and target innervation. Particularly, a short-range signal transducer, the neural cell adhesion molecule (NCAM), stimulates neurite outgrowth via mechanisms that require posttranslational modification of NCAM and signaling via receptors to a long-range messenger, the fibroblast growth factor (FGF). In the present study we further characterized a mechanism which regulates the functional interplay between NCAM and FGF receptor(s). We show that activation of FGF receptor(s) by FGF2 leads to palmitoylation of the two major transmembrane NCAM isoforms, NCAM140 and NCAM180, translocation of NCAM to GM1 ganglioside-containing lipid rafts, and stimulation of neurite outgrowth of hippocampal neurons. Ablation of NCAM, mutation of NCAM140 or NCAM180 palmitoylation sites, or pharmacological suppression of NCAM signaling inhibited FGF2-stimulated neurite outgrowth. Of the 23 members...
doi10.1523/JNEUROSCI.2171-08.2008
pmid18768683
date2008-09-03