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Effect of caloric restriction on longevity

Calorie restriction (CR) is the most evaluated nutritional intervention to increase lifespan in a variety of animal species, including human beings. CR has also been shown to delay the onset or reduce the incidence of many age-related diseases. The mechanism that could explain the effect of calorie... Full description

Journal Title: Arquivos brasileiros de endocrinologia e metabologia July 2009, Vol.53(5), pp.667-72
Main Author: Genaro, Patrícia De Souza
Other Authors: Sarkis, Karin Sedó , Martini, Ligia Araújo
Format: Electronic Article Electronic Article
Language: Portugiesisch
Subjects:
Quelle: MEDLINE/PubMed (U.S. National Library of Medicine)
ID: E-ISSN: 1677-9487 ; PMID: 19768257 Version:1
Link: http://pubmed.gov/19768257
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recordid: medline19768257
title: Effect of caloric restriction on longevity
format: Article
creator:
  • Genaro, Patrícia De Souza
  • Sarkis, Karin Sedó
  • Martini, Ligia Araújo
subjects:
  • Caloric Restriction
  • Diet
  • Longevity -- Physiology
ispartof: Arquivos brasileiros de endocrinologia e metabologia, July 2009, Vol.53(5), pp.667-72
description: Calorie restriction (CR) is the most evaluated nutritional intervention to increase lifespan in a variety of animal species, including human beings. CR has also been shown to delay the onset or reduce the incidence of many age-related diseases. The mechanism that could explain the effect of calorie intake on aging is related to the reduction of body fat and insulin signaling as well as reactive oxygen species produced during breathing. These phenomena cause oxidative damage to DNA and RNA promoting the process of aging and increasing the risk of illnesses. However, the effect of CR on longevity in human beings is not fully established and further studies are necessary in order to identify the molecular and cellular mechanisms for the therapeutic effect of RC. Moreover, it is necessary to set up the differences between the beneficial effects of caloric restriction from those related to dietary healthy habits.
language: por
source: MEDLINE/PubMed (U.S. National Library of Medicine)
identifier: E-ISSN: 1677-9487 ; PMID: 19768257 Version:1
fulltext: fulltext
issn:
  • 16779487
  • 1677-9487
url: Link


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subjectCaloric Restriction ; Diet ; Longevity -- Physiology
descriptionCalorie restriction (CR) is the most evaluated nutritional intervention to increase lifespan in a variety of animal species, including human beings. CR has also been shown to delay the onset or reduce the incidence of many age-related diseases. The mechanism that could explain the effect of calorie intake on aging is related to the reduction of body fat and insulin signaling as well as reactive oxygen species produced during breathing. These phenomena cause oxidative damage to DNA and RNA promoting the process of aging and increasing the risk of illnesses. However, the effect of CR on longevity in human beings is not fully established and further studies are necessary in order to identify the molecular and cellular mechanisms for the therapeutic effect of RC. Moreover, it is necessary to set up the differences between the beneficial effects of caloric restriction from those related to dietary healthy habits.
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abstractCalorie restriction (CR) is the most evaluated nutritional intervention to increase lifespan in a variety of animal species, including human beings. CR has also been shown to delay the onset or reduce the incidence of many age-related diseases. The mechanism that could explain the effect of calorie intake on aging is related to the reduction of body fat and insulin signaling as well as reactive oxygen species produced during breathing. These phenomena cause oxidative damage to DNA and RNA promoting the process of aging and increasing the risk of illnesses. However, the effect of CR on longevity in human beings is not fully established and further studies are necessary in order to identify the molecular and cellular mechanisms for the therapeutic effect of RC. Moreover, it is necessary to set up the differences between the beneficial effects of caloric restriction from those related to dietary healthy habits.
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