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Structure of a two-G-tetrad intramolecular G-quadruplex formed by a variant human telomeric sequence in K+ solution: insights into the interconversion of human telomeric G-quadruplex structures

Human telomeric DNA G-quadruplex has been considered as an attractive target for cancer therapeutic intervention. The telomeric sequence shows intrinsic structure polymorphism. Here we report a novel intramolecular G-quadruplex structure formed by a variant human telomeric sequence in K(+) solution.... Full description

Journal Title: Nucleic acids research January 2010, Vol.38(3), pp.1009-21
Main Author: Zhang, Zhenjiang
Other Authors: Dai, Jixun , Veliath, Elizabeth , Jones, Roger A , Yang, Danzhou
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1362-4962 ; PMID: 19946019 Version:1 ; DOI: 10.1093/nar/gkp1029
Link: http://pubmed.gov/19946019
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title: Structure of a two-G-tetrad intramolecular G-quadruplex formed by a variant human telomeric sequence in K+ solution: insights into the interconversion of human telomeric G-quadruplex structures
format: Article
creator:
  • Zhang, Zhenjiang
  • Dai, Jixun
  • Veliath, Elizabeth
  • Jones, Roger A
  • Yang, Danzhou
subjects:
  • G-Quadruplexes
  • DNA -- Chemistry
  • Potassium -- Chemistry
  • Telomere -- Chemistry
ispartof: Nucleic acids research, January 2010, Vol.38(3), pp.1009-21
description: Human telomeric DNA G-quadruplex has been considered as an attractive target for cancer therapeutic intervention. The telomeric sequence shows intrinsic structure polymorphism. Here we report a novel intramolecular G-quadruplex structure formed by a variant human telomeric sequence in K(+) solution. This sequence forms a basket-type intramolecular G-quadruplex with only two G-tetrads but multiple-layer capping structures formed by loop residues. While it is shown that this structure can only be detected in the specifically truncated telomeric sequences without any 5'-flanking residues, our results suggest that this two-G-tetrad conformation is likely to be an intermediate form of the interconversion of different telomeric G-quadruplex conformations.
language: eng
source:
identifier: E-ISSN: 1362-4962 ; PMID: 19946019 Version:1 ; DOI: 10.1093/nar/gkp1029
fulltext: fulltext
issn:
  • 13624962
  • 1362-4962
url: Link


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titleStructure of a two-G-tetrad intramolecular G-quadruplex formed by a variant human telomeric sequence in K+ solution: insights into the interconversion of human telomeric G-quadruplex structures
creatorZhang, Zhenjiang ; Dai, Jixun ; Veliath, Elizabeth ; Jones, Roger A ; Yang, Danzhou
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subjectG-Quadruplexes ; DNA -- Chemistry ; Potassium -- Chemistry ; Telomere -- Chemistry
descriptionHuman telomeric DNA G-quadruplex has been considered as an attractive target for cancer therapeutic intervention. The telomeric sequence shows intrinsic structure polymorphism. Here we report a novel intramolecular G-quadruplex structure formed by a variant human telomeric sequence in K(+) solution. This sequence forms a basket-type intramolecular G-quadruplex with only two G-tetrads but multiple-layer capping structures formed by loop residues. While it is shown that this structure can only be detected in the specifically truncated telomeric sequences without any 5'-flanking residues, our results suggest that this two-G-tetrad conformation is likely to be an intermediate form of the interconversion of different telomeric G-quadruplex conformations.
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titleStructure of a two-G-tetrad intramolecular G-quadruplex formed by a variant human telomeric sequence in K+ solution: insights into the interconversion of human telomeric G-quadruplex structures
descriptionHuman telomeric DNA G-quadruplex has been considered as an attractive target for cancer therapeutic intervention. The telomeric sequence shows intrinsic structure polymorphism. Here we report a novel intramolecular G-quadruplex structure formed by a variant human telomeric sequence in K(+) solution. This sequence forms a basket-type intramolecular G-quadruplex with only two G-tetrads but multiple-layer capping structures formed by loop residues. While it is shown that this structure can only be detected in the specifically truncated telomeric sequences without any 5'-flanking residues, our results suggest that this two-G-tetrad conformation is likely to be an intermediate form of the interconversion of different telomeric G-quadruplex conformations.
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titleStructure of a two-G-tetrad intramolecular G-quadruplex formed by a variant human telomeric sequence in K+ solution: insights into the interconversion of human telomeric G-quadruplex structures
authorZhang, Zhenjiang ; Dai, Jixun ; Veliath, Elizabeth ; Jones, Roger A ; Yang, Danzhou
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abstractHuman telomeric DNA G-quadruplex has been considered as an attractive target for cancer therapeutic intervention. The telomeric sequence shows intrinsic structure polymorphism. Here we report a novel intramolecular G-quadruplex structure formed by a variant human telomeric sequence in K(+) solution. This sequence forms a basket-type intramolecular G-quadruplex with only two G-tetrads but multiple-layer capping structures formed by loop residues. While it is shown that this structure can only be detected in the specifically truncated telomeric sequences without any 5'-flanking residues, our results suggest that this two-G-tetrad conformation is likely to be an intermediate form of the interconversion of different telomeric G-quadruplex conformations.
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