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AKT2 expression is associated with glioma malignant progression and required for cell survival and invasion

Recent data suggest that AKT2, one of AKT isoforms, plays an important role in tumorigenesis of human cancers. However, little evidence exists to show the mechanism of AKT2 involved in tumorigenesis. In this study, we show that AKT2 protein expression increased significantly in high grade gliomas in... Full description

Journal Title: Oncology reports July 2010, Vol.24(1), pp.65-72
Main Author: Zhang, Junxia
Other Authors: Han, Lei , Zhang, Anling , Wang, Yingyi , Yue, Xiao , You, Yongping , Pu, Peiyu , Kang, Chunsheng
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1791-2431 ; PMID: 20514445 Version:1
Link: http://pubmed.gov/20514445
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recordid: medline20514445
title: AKT2 expression is associated with glioma malignant progression and required for cell survival and invasion
format: Article
creator:
  • Zhang, Junxia
  • Han, Lei
  • Zhang, Anling
  • Wang, Yingyi
  • Yue, Xiao
  • You, Yongping
  • Pu, Peiyu
  • Kang, Chunsheng
subjects:
  • Brain Neoplasms -- Pathology
  • Glioma -- Pathology
  • Proto-Oncogene Proteins C-Akt -- Genetics
ispartof: Oncology reports, July 2010, Vol.24(1), pp.65-72
description: Recent data suggest that AKT2, one of AKT isoforms, plays an important role in tumorigenesis of human cancers. However, little evidence exists to show the mechanism of AKT2 involved in tumorigenesis. In this study, we show that AKT2 protein expression increased significantly in high grade gliomas in comparison to low grade gliomas and correlated with the expression of NFkappaB, BCL2, MMP2 and MMP9 by immunostaining. Further, down-regulation of AKT2 expression by antisense AKT2 induced glioma cell apoptosis mediated by NFkappaB and BCL2. In addition, decreased MMP2 and MMP9 expression in AKT2 knocked-down glioma cells was subsequently detected, consistent with the decreased invasion. These findings indicate that AKT2 expression is associated with more advanced and especially aggressive gliomas and critical for cell survival and invasion.
language: eng
source:
identifier: E-ISSN: 1791-2431 ; PMID: 20514445 Version:1
fulltext: fulltext
issn:
  • 17912431
  • 1791-2431
url: Link


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titleAKT2 expression is associated with glioma malignant progression and required for cell survival and invasion
creatorZhang, Junxia ; Han, Lei ; Zhang, Anling ; Wang, Yingyi ; Yue, Xiao ; You, Yongping ; Pu, Peiyu ; Kang, Chunsheng
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subjectBrain Neoplasms -- Pathology ; Glioma -- Pathology ; Proto-Oncogene Proteins C-Akt -- Genetics
descriptionRecent data suggest that AKT2, one of AKT isoforms, plays an important role in tumorigenesis of human cancers. However, little evidence exists to show the mechanism of AKT2 involved in tumorigenesis. In this study, we show that AKT2 protein expression increased significantly in high grade gliomas in comparison to low grade gliomas and correlated with the expression of NFkappaB, BCL2, MMP2 and MMP9 by immunostaining. Further, down-regulation of AKT2 expression by antisense AKT2 induced glioma cell apoptosis mediated by NFkappaB and BCL2. In addition, decreased MMP2 and MMP9 expression in AKT2 knocked-down glioma cells was subsequently detected, consistent with the decreased invasion. These findings indicate that AKT2 expression is associated with more advanced and especially aggressive gliomas and critical for cell survival and invasion.
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titleAKT2 expression is associated with glioma malignant progression and required for cell survival and invasion
descriptionRecent data suggest that AKT2, one of AKT isoforms, plays an important role in tumorigenesis of human cancers. However, little evidence exists to show the mechanism of AKT2 involved in tumorigenesis. In this study, we show that AKT2 protein expression increased significantly in high grade gliomas in comparison to low grade gliomas and correlated with the expression of NFkappaB, BCL2, MMP2 and MMP9 by immunostaining. Further, down-regulation of AKT2 expression by antisense AKT2 induced glioma cell apoptosis mediated by NFkappaB and BCL2. In addition, decreased MMP2 and MMP9 expression in AKT2 knocked-down glioma cells was subsequently detected, consistent with the decreased invasion. These findings indicate that AKT2 expression is associated with more advanced and especially aggressive gliomas and critical for cell survival and invasion.
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titleAKT2 expression is associated with glioma malignant progression and required for cell survival and invasion
authorZhang, Junxia ; Han, Lei ; Zhang, Anling ; Wang, Yingyi ; Yue, Xiao ; You, Yongping ; Pu, Peiyu ; Kang, Chunsheng
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abstractRecent data suggest that AKT2, one of AKT isoforms, plays an important role in tumorigenesis of human cancers. However, little evidence exists to show the mechanism of AKT2 involved in tumorigenesis. In this study, we show that AKT2 protein expression increased significantly in high grade gliomas in comparison to low grade gliomas and correlated with the expression of NFkappaB, BCL2, MMP2 and MMP9 by immunostaining. Further, down-regulation of AKT2 expression by antisense AKT2 induced glioma cell apoptosis mediated by NFkappaB and BCL2. In addition, decreased MMP2 and MMP9 expression in AKT2 knocked-down glioma cells was subsequently detected, consistent with the decreased invasion. These findings indicate that AKT2 expression is associated with more advanced and especially aggressive gliomas and critical for cell survival and invasion.
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