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Granulosa cell ligand NPPC and its receptor NPR2 maintain meiotic arrest in mouse oocytes

Granulosa cells of mammalian Graafian follicles maintain oocytes in meiotic arrest, which prevents their precocious maturation. We show that mouse mural granulosa cells, which line the follicle wall, express natriuretic peptide precursor type C (Nppc) messenger RNA (mRNA), whereas cumulus cells surr... Full description

Journal Title: Science (New York N.Y.), 15 October 2010, Vol.330(6002), pp.366-9
Main Author: Zhang, Meijia
Other Authors: Su, You-Qiang , Sugiura, Koji , Xia, Guoliang , Eppig, John J
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1095-9203 ; PMID: 20947764 Version:1 ; DOI: 10.1126/science.1193573
Link: http://pubmed.gov/20947764
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recordid: medline20947764
title: Granulosa cell ligand NPPC and its receptor NPR2 maintain meiotic arrest in mouse oocytes
format: Article
creator:
  • Zhang, Meijia
  • Su, You-Qiang
  • Sugiura, Koji
  • Xia, Guoliang
  • Eppig, John J
subjects:
  • Meiosis
  • Cumulus Cells -- Metabolism
  • Granulosa Cells -- Metabolism
  • Natriuretic Peptide, C-Type -- Metabolism
  • Oocytes -- Physiology
  • Protein Precursors -- Metabolism
  • Receptors, Atrial Natriuretic Factor -- Metabolism
ispartof: Science (New York, N.Y.), 15 October 2010, Vol.330(6002), pp.366-9
description: Granulosa cells of mammalian Graafian follicles maintain oocytes in meiotic arrest, which prevents their precocious maturation. We show that mouse mural granulosa cells, which line the follicle wall, express natriuretic peptide precursor type C (Nppc) messenger RNA (mRNA), whereas cumulus cells surrounding oocytes express mRNA of the NPPC receptor NPR2, a guanylyl cyclase. NPPC increased cGMP levels in cumulus cells and oocytes and inhibited meiotic resumption in vitro. Meiotic arrest was not sustained in most Graafian follicles of Nppc or Npr2 mutant mice, and meiosis resumed precociously. Oocyte-derived paracrine factors promoted cumulus cell expression of Npr2 mRNA. Therefore, the granulosa cell ligand NPPC and its receptor NPR2 in cumulus cells prevent precocious meiotic maturation, which is critical for maturation and ovulation synchrony and for normal female fertility.
language: eng
source:
identifier: E-ISSN: 1095-9203 ; PMID: 20947764 Version:1 ; DOI: 10.1126/science.1193573
fulltext: no_fulltext
issn:
  • 10959203
  • 1095-9203
url: Link


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titleGranulosa cell ligand NPPC and its receptor NPR2 maintain meiotic arrest in mouse oocytes
creatorZhang, Meijia ; Su, You-Qiang ; Sugiura, Koji ; Xia, Guoliang ; Eppig, John J
ispartofScience (New York, N.Y.), 15 October 2010, Vol.330(6002), pp.366-9
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subjectMeiosis ; Cumulus Cells -- Metabolism ; Granulosa Cells -- Metabolism ; Natriuretic Peptide, C-Type -- Metabolism ; Oocytes -- Physiology ; Protein Precursors -- Metabolism ; Receptors, Atrial Natriuretic Factor -- Metabolism
descriptionGranulosa cells of mammalian Graafian follicles maintain oocytes in meiotic arrest, which prevents their precocious maturation. We show that mouse mural granulosa cells, which line the follicle wall, express natriuretic peptide precursor type C (Nppc) messenger RNA (mRNA), whereas cumulus cells surrounding oocytes express mRNA of the NPPC receptor NPR2, a guanylyl cyclase. NPPC increased cGMP levels in cumulus cells and oocytes and inhibited meiotic resumption in vitro. Meiotic arrest was not sustained in most Graafian follicles of Nppc or Npr2 mutant mice, and meiosis resumed precociously. Oocyte-derived paracrine factors promoted cumulus cell expression of Npr2 mRNA. Therefore, the granulosa cell ligand NPPC and its receptor NPR2 in cumulus cells prevent precocious meiotic maturation, which is critical for maturation and ovulation synchrony and for normal female fertility.
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titleGranulosa cell ligand NPPC and its receptor NPR2 maintain meiotic arrest in mouse oocytes
descriptionGranulosa cells of mammalian Graafian follicles maintain oocytes in meiotic arrest, which prevents their precocious maturation. We show that mouse mural granulosa cells, which line the follicle wall, express natriuretic peptide precursor type C (Nppc) messenger RNA (mRNA), whereas cumulus cells surrounding oocytes express mRNA of the NPPC receptor NPR2, a guanylyl cyclase. NPPC increased cGMP levels in cumulus cells and oocytes and inhibited meiotic resumption in vitro. Meiotic arrest was not sustained in most Graafian follicles of Nppc or Npr2 mutant mice, and meiosis resumed precociously. Oocyte-derived paracrine factors promoted cumulus cell expression of Npr2 mRNA. Therefore, the granulosa cell ligand NPPC and its receptor NPR2 in cumulus cells prevent precocious meiotic maturation, which is critical for maturation and ovulation synchrony and for normal female fertility.
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abstractGranulosa cells of mammalian Graafian follicles maintain oocytes in meiotic arrest, which prevents their precocious maturation. We show that mouse mural granulosa cells, which line the follicle wall, express natriuretic peptide precursor type C (Nppc) messenger RNA (mRNA), whereas cumulus cells surrounding oocytes express mRNA of the NPPC receptor NPR2, a guanylyl cyclase. NPPC increased cGMP levels in cumulus cells and oocytes and inhibited meiotic resumption in vitro. Meiotic arrest was not sustained in most Graafian follicles of Nppc or Npr2 mutant mice, and meiosis resumed precociously. Oocyte-derived paracrine factors promoted cumulus cell expression of Npr2 mRNA. Therefore, the granulosa cell ligand NPPC and its receptor NPR2 in cumulus cells prevent precocious meiotic maturation, which is critical for maturation and ovulation synchrony and for normal female fertility.
doi10.1126/science.1193573
pmid20947764
date2010-10-15