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Localization and androgen regulation of metastasis-associated protein 1 in mouse epididymis

Metastasis-associated protein 1 (MTA1), the founding member of the MTA family of genes, can modulate transcription by influencing the status of chromatin remodeling. Despite its strong correlation with the metastatic potential of cancer cells, MTA1 can also regulate crucial cellular pathways by modi... Full description

Journal Title: PloS one 03 November 2010, Vol.5(11), pp.e15439
Main Author: Ma, Li
Other Authors: Li, Wei , Zhu, Hua-Ping , Li, Zhen , Sun, Zhi-Jian , Liu, Xin-Ping , Zhao, Jie , Zhang, Jin-Shan , Zhang, Yuan-Qiang
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1932-6203 ; PMID: 21082030 Version:1 ; DOI: 10.1371/journal.pone.0015439
Link: http://pubmed.gov/21082030
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recordid: medline21082030
title: Localization and androgen regulation of metastasis-associated protein 1 in mouse epididymis
format: Article
creator:
  • Ma, Li
  • Li, Wei
  • Zhu, Hua-Ping
  • Li, Zhen
  • Sun, Zhi-Jian
  • Liu, Xin-Ping
  • Zhao, Jie
  • Zhang, Jin-Shan
  • Zhang, Yuan-Qiang
subjects:
  • Androgens -- Metabolism
  • Epididymis -- Metabolism
  • Transcription Factors -- Metabolism
ispartof: PloS one, 03 November 2010, Vol.5(11), pp.e15439
description: Metastasis-associated protein 1 (MTA1), the founding member of the MTA family of genes, can modulate transcription by influencing the status of chromatin remodeling. Despite its strong correlation with the metastatic potential of cancer cells, MTA1 can also regulate crucial cellular pathways by modifying the acetylation status. We have previously reported the presence of MTA1/MTA1 in human and mouse testes, providing the evidence for its involvement in the regulation of testicular function during murine spermatogenesis. The objective of present study was to further assess the localization of MTA1 in mouse epididymis on both transcriptional and translational level, and then to explore whether MTA1 expression is regulated by androgens and postnatal epididymal development. Mice were deprived of circulating androgen by bilaterally castration and were then supplemented with exogenous testosterone propionate for one week. MTA1 was immunolocalized in the epithelium of the entire epididymis with the maximal expression in the nuclei of principal cells and of clear cells in proximal region. Its expression decreased gradually after castration, whereas testosterone treatment could restore the expression, indicating that the expression of this gene is dependent on androgen. During postnatal development, the protein expression in the epididymis began to appear from day 7 to day 14, increased dramatically from postnatal day 28, and peaked at adulthood onwards, coinciding with both the well differentiated status of epididymis and the mature levels of circulating androgens. This region- and cell-specific pattern was also conservative in normal human epididymis. Our data suggest that the expression of MTA1 protein could be regulated by androgen pathway and its expression level is closely associated with the postnatal development of the epididymis, giving rise to the possibility that this gene plays a potential role in sperm maturation and fertility.
language: eng
source:
identifier: E-ISSN: 1932-6203 ; PMID: 21082030 Version:1 ; DOI: 10.1371/journal.pone.0015439
fulltext: fulltext
issn:
  • 19326203
  • 1932-6203
url: Link


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titleLocalization and androgen regulation of metastasis-associated protein 1 in mouse epididymis
creatorMa, Li ; Li, Wei ; Zhu, Hua-Ping ; Li, Zhen ; Sun, Zhi-Jian ; Liu, Xin-Ping ; Zhao, Jie ; Zhang, Jin-Shan ; Zhang, Yuan-Qiang
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subjectAndrogens -- Metabolism ; Epididymis -- Metabolism ; Transcription Factors -- Metabolism
descriptionMetastasis-associated protein 1 (MTA1), the founding member of the MTA family of genes, can modulate transcription by influencing the status of chromatin remodeling. Despite its strong correlation with the metastatic potential of cancer cells, MTA1 can also regulate crucial cellular pathways by modifying the acetylation status. We have previously reported the presence of MTA1/MTA1 in human and mouse testes, providing the evidence for its involvement in the regulation of testicular function during murine spermatogenesis. The objective of present study was to further assess the localization of MTA1 in mouse epididymis on both transcriptional and translational level, and then to explore whether MTA1 expression is regulated by androgens and postnatal epididymal development. Mice were deprived of circulating androgen by bilaterally castration and were then supplemented with exogenous testosterone propionate for one week. MTA1 was immunolocalized in the epithelium of the entire epididymis with the maximal expression in the nuclei of principal cells and of clear cells in proximal region. Its expression decreased gradually after castration, whereas testosterone treatment could restore the expression, indicating that the expression of this gene is dependent on androgen. During postnatal development, the protein expression in the epididymis began to appear from day 7 to day 14, increased dramatically from postnatal day 28, and peaked at adulthood onwards, coinciding with both the well differentiated status of epididymis and the mature levels of circulating androgens. This region- and cell-specific pattern was also conservative in normal human epididymis. Our data suggest that the expression of MTA1 protein could be regulated by androgen pathway and its expression level is closely associated with the postnatal development of the epididymis, giving rise to the possibility that this gene plays a potential role in sperm maturation and fertility.
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titleLocalization and androgen regulation of metastasis-associated protein 1 in mouse epididymis
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0Metastasis-associated protein 1 (MTA1), the founding member of the MTA family of genes, can modulate transcription by influencing the status of chromatin remodeling. Despite its strong correlation with the metastatic potential of cancer cells, MTA1 can also regulate crucial cellular pathways by modifying the acetylation status. We have previously reported the presence of MTA1/MTA1 in human and mouse testes, providing the evidence for its involvement in the regulation of testicular function during murine spermatogenesis. The objective of present study was to further assess the localization of MTA1 in mouse epididymis on both transcriptional and translational level, and then to explore whether MTA1 expression is regulated by androgens and postnatal epididymal development.
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abstractMetastasis-associated protein 1 (MTA1), the founding member of the MTA family of genes, can modulate transcription by influencing the status of chromatin remodeling. Despite its strong correlation with the metastatic potential of cancer cells, MTA1 can also regulate crucial cellular pathways by modifying the acetylation status. We have previously reported the presence of MTA1/MTA1 in human and mouse testes, providing the evidence for its involvement in the regulation of testicular function during murine spermatogenesis. The objective of present study was to further assess the localization of MTA1 in mouse epididymis on both transcriptional and translational level, and then to explore whether MTA1 expression is regulated by androgens and postnatal epididymal development.
doi10.1371/journal.pone.0015439
pmid21082030
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date2010-11-03