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Involvement of CD226+ NK cells in immunopathogenesis of systemic lupus erythematosus

Dysfunction of immune systems, including innate and adaptive immunity, is responsible for the immunopathogenesis of systemic lupus erythematosus (SLE). NK cells are a major part of the innate immune system, and diminished populations of NK cells have been reported in SLE patients. However, the mecha... Full description

Journal Title: Journal of immunology (Baltimore Md. : 1950), 15 March 2011, Vol.186(6), pp.3421-31
Main Author: Huang, Zhan
Other Authors: Fu, Binqing , Zheng, Song Guo , Li, Xiaomei , Sun, Rui , Tian, Zhigang , Wei, Haiming
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1550-6606 ; PMID: 21296979 Version:1 ; DOI: 10.4049/jimmunol.1000569
Link: http://pubmed.gov/21296979
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recordid: medline21296979
title: Involvement of CD226+ NK cells in immunopathogenesis of systemic lupus erythematosus
format: Article
creator:
  • Huang, Zhan
  • Fu, Binqing
  • Zheng, Song Guo
  • Li, Xiaomei
  • Sun, Rui
  • Tian, Zhigang
  • Wei, Haiming
subjects:
  • Antigens, Differentiation, T-Lymphocyte -- Biosynthesis
  • Killer Cells, Natural -- Immunology
  • Lupus Erythematosus, Systemic -- Immunology
ispartof: Journal of immunology (Baltimore, Md. : 1950), 15 March 2011, Vol.186(6), pp.3421-31
description: Dysfunction of immune systems, including innate and adaptive immunity, is responsible for the immunopathogenesis of systemic lupus erythematosus (SLE). NK cells are a major part of the innate immune system, and diminished populations of NK cells have been reported in SLE patients. However, the mechanisms behind this decrease and the role of NK cells in SLE pathogenesis remain poorly understood. In this study, we found that a deficiency of NK cells, especially CD226(+) NK cells, is prominent in patients with active SLE. Meanwhile, expression of the CD226 ligands CD112 and CD155 on plasmacytoid dendritic cells is observed in SLE patients; thus, activation of CD226(+) NK cells may be induced by CD226-ligand interactions. Furthermore, IFN-α, which is mainly produced by plasmacytoid dendritic cells, can mediate the activation-induced cell death of NK cells. Therefore, these processes likely contribute to the loss of NK cells in patients with active SLE. Despite the impaired cytotoxicity of peripheral...
language: eng
source:
identifier: E-ISSN: 1550-6606 ; PMID: 21296979 Version:1 ; DOI: 10.4049/jimmunol.1000569
fulltext: fulltext
issn:
  • 15506606
  • 1550-6606
url: Link


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titleInvolvement of CD226+ NK cells in immunopathogenesis of systemic lupus erythematosus
creatorHuang, Zhan ; Fu, Binqing ; Zheng, Song Guo ; Li, Xiaomei ; Sun, Rui ; Tian, Zhigang ; Wei, Haiming
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subjectAntigens, Differentiation, T-Lymphocyte -- Biosynthesis ; Killer Cells, Natural -- Immunology ; Lupus Erythematosus, Systemic -- Immunology
descriptionDysfunction of immune systems, including innate and adaptive immunity, is responsible for the immunopathogenesis of systemic lupus erythematosus (SLE). NK cells are a major part of the innate immune system, and diminished populations of NK cells have been reported in SLE patients. However, the mechanisms behind this decrease and the role of NK cells in SLE pathogenesis remain poorly understood. In this study, we found that a deficiency of NK cells, especially CD226(+) NK cells, is prominent in patients with active SLE. Meanwhile, expression of the CD226 ligands CD112 and CD155 on plasmacytoid dendritic cells is observed in SLE patients; thus, activation of CD226(+) NK cells may be induced by CD226-ligand interactions. Furthermore, IFN-α, which is mainly produced by plasmacytoid dendritic cells, can mediate the activation-induced cell death of NK cells. Therefore, these processes likely contribute to the loss of NK cells in patients with active SLE. Despite the impaired cytotoxicity of peripheral...
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descriptionDysfunction of immune systems, including innate and adaptive immunity, is responsible for the immunopathogenesis of systemic lupus erythematosus (SLE). NK cells are a major part of the innate immune system, and diminished populations of NK cells have been reported in SLE patients. However, the mechanisms behind this decrease and the role of NK cells in SLE pathogenesis remain poorly understood. In this study, we found that a deficiency of NK cells, especially CD226(+) NK cells, is prominent in patients with active SLE. Meanwhile, expression of the CD226 ligands CD112 and CD155 on plasmacytoid dendritic cells is observed in SLE patients; thus, activation of CD226(+) NK cells may be induced by CD226-ligand interactions. Furthermore, IFN-α, which is mainly produced by plasmacytoid dendritic cells, can mediate the activation-induced cell death of NK cells. Therefore, these processes likely contribute to the loss of NK cells in patients with active SLE. Despite the impaired cytotoxicity of peripheral...
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abstractDysfunction of immune systems, including innate and adaptive immunity, is responsible for the immunopathogenesis of systemic lupus erythematosus (SLE). NK cells are a major part of the innate immune system, and diminished populations of NK cells have been reported in SLE patients. However, the mechanisms behind this decrease and the role of NK cells in SLE pathogenesis remain poorly understood. In this study, we found that a deficiency of NK cells, especially CD226(+) NK cells, is prominent in patients with active SLE. Meanwhile, expression of the CD226 ligands CD112 and CD155 on plasmacytoid dendritic cells is observed in SLE patients; thus, activation of CD226(+) NK cells may be induced by CD226-ligand interactions. Furthermore, IFN-α, which is mainly produced by plasmacytoid dendritic cells, can mediate the activation-induced cell death of NK cells. Therefore, these processes likely contribute to the loss of NK cells in patients with active SLE. Despite the impaired cytotoxicity of peripheral...
doi10.4049/jimmunol.1000569
pmid21296979
date2011-03-15