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Targeting antigen to mouse dendritic cells via Clec9A induces potent CD4 T cell responses biased toward a follicular helper phenotype

Three surface molecules of mouse CD8(+) dendritic cells (DCs), also found on the equivalent human DC subpopulation, were compared as targets for Ab-mediated delivery of Ags, a developing strategy for vaccination. For the production of cytotoxic T cells, DEC-205 and Clec9A, but not Clec12A, were effe... Full description

Journal Title: Journal of immunology (Baltimore Md. : 1950), 15 July 2011, Vol.187(2), pp.842-50
Main Author: Lahoud, Mireille H
Other Authors: Ahmet, Fatma , Kitsoulis, Susie , Wan, Soo San , Vremec, David , Lee, Chin-Nien , Phipson, Belinda , Shi, Wei , Smyth, Gordon K , Lew, Andrew M , Kato, Yu , Mueller, Scott N , Davey, Gayle M , Heath, William R , Shortman, Ken , Caminschi, Irina
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1550-6606 ; PMID: 21677141 Version:1 ; DOI: 10.4049/jimmunol.1101176
Link: http://pubmed.gov/21677141
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recordid: medline21677141
title: Targeting antigen to mouse dendritic cells via Clec9A induces potent CD4 T cell responses biased toward a follicular helper phenotype
format: Article
creator:
  • Lahoud, Mireille H
  • Ahmet, Fatma
  • Kitsoulis, Susie
  • Wan, Soo San
  • Vremec, David
  • Lee, Chin-Nien
  • Phipson, Belinda
  • Shi, Wei
  • Smyth, Gordon K
  • Lew, Andrew M
  • Kato, Yu
  • Mueller, Scott N
  • Davey, Gayle M
  • Heath, William R
  • Shortman, Ken
  • Caminschi, Irina
subjects:
  • Cytotoxicity Tests, Immunologic
  • Immunophenotyping
  • Antigen Presentation -- Immunology
  • Cd4-Positive T-Lymphocytes -- Immunology
  • Dendritic Cells -- Immunology
  • Lectins, C-Type -- Metabolism
  • Receptors, Immunologic -- Metabolism
ispartof: Journal of immunology (Baltimore, Md. : 1950), 15 July 2011, Vol.187(2), pp.842-50
description: Three surface molecules of mouse CD8(+) dendritic cells (DCs), also found on the equivalent human DC subpopulation, were compared as targets for Ab-mediated delivery of Ags, a developing strategy for vaccination. For the production of cytotoxic T cells, DEC-205 and Clec9A, but not Clec12A, were effective targets, although only in the presence of adjuvants. For Ab production, however, Clec9A excelled as a target, even in the absence of adjuvant. Potent humoral immunity was a result of the highly specific expression of Clec9A on DCs, which allowed longer residence of targeting Abs in the bloodstream, prolonged DC Ag presentation, and extended CD4 T cell proliferation, all of which drove highly efficient development of follicular helper T cells. Because Clec9A shows a similar expression pattern on human DCs, it has particular promise as a target for vaccines of human application.
language: eng
source:
identifier: E-ISSN: 1550-6606 ; PMID: 21677141 Version:1 ; DOI: 10.4049/jimmunol.1101176
fulltext: fulltext
issn:
  • 15506606
  • 1550-6606
url: Link


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titleTargeting antigen to mouse dendritic cells via Clec9A induces potent CD4 T cell responses biased toward a follicular helper phenotype
creatorLahoud, Mireille H ; Ahmet, Fatma ; Kitsoulis, Susie ; Wan, Soo San ; Vremec, David ; Lee, Chin-Nien ; Phipson, Belinda ; Shi, Wei ; Smyth, Gordon K ; Lew, Andrew M ; Kato, Yu ; Mueller, Scott N ; Davey, Gayle M ; Heath, William R ; Shortman, Ken ; Caminschi, Irina
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subjectCytotoxicity Tests, Immunologic ; Immunophenotyping ; Antigen Presentation -- Immunology ; Cd4-Positive T-Lymphocytes -- Immunology ; Dendritic Cells -- Immunology ; Lectins, C-Type -- Metabolism ; Receptors, Immunologic -- Metabolism
descriptionThree surface molecules of mouse CD8(+) dendritic cells (DCs), also found on the equivalent human DC subpopulation, were compared as targets for Ab-mediated delivery of Ags, a developing strategy for vaccination. For the production of cytotoxic T cells, DEC-205 and Clec9A, but not Clec12A, were effective targets, although only in the presence of adjuvants. For Ab production, however, Clec9A excelled as a target, even in the absence of adjuvant. Potent humoral immunity was a result of the highly specific expression of Clec9A on DCs, which allowed longer residence of targeting Abs in the bloodstream, prolonged DC Ag presentation, and extended CD4 T cell proliferation, all of which drove highly efficient development of follicular helper T cells. Because Clec9A shows a similar expression pattern on human DCs, it has particular promise as a target for vaccines of human application.
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titleTargeting antigen to mouse dendritic cells via Clec9A induces potent CD4 T cell responses biased toward a follicular helper phenotype
descriptionThree surface molecules of mouse CD8(+) dendritic cells (DCs), also found on the equivalent human DC subpopulation, were compared as targets for Ab-mediated delivery of Ags, a developing strategy for vaccination. For the production of cytotoxic T cells, DEC-205 and Clec9A, but not Clec12A, were effective targets, although only in the presence of adjuvants. For Ab production, however, Clec9A excelled as a target, even in the absence of adjuvant. Potent humoral immunity was a result of the highly specific expression of Clec9A on DCs, which allowed longer residence of targeting Abs in the bloodstream, prolonged DC Ag presentation, and extended CD4 T cell proliferation, all of which drove highly efficient development of follicular helper T cells. Because Clec9A shows a similar expression pattern on human DCs, it has particular promise as a target for vaccines of human application.
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atitleTargeting antigen to mouse dendritic cells via Clec9A induces potent CD4 T cell responses biased toward a follicular helper phenotype
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abstractThree surface molecules of mouse CD8(+) dendritic cells (DCs), also found on the equivalent human DC subpopulation, were compared as targets for Ab-mediated delivery of Ags, a developing strategy for vaccination. For the production of cytotoxic T cells, DEC-205 and Clec9A, but not Clec12A, were effective targets, although only in the presence of adjuvants. For Ab production, however, Clec9A excelled as a target, even in the absence of adjuvant. Potent humoral immunity was a result of the highly specific expression of Clec9A on DCs, which allowed longer residence of targeting Abs in the bloodstream, prolonged DC Ag presentation, and extended CD4 T cell proliferation, all of which drove highly efficient development of follicular helper T cells. Because Clec9A shows a similar expression pattern on human DCs, it has particular promise as a target for vaccines of human application.
doi10.4049/jimmunol.1101176
pmid21677141
date2011-07-15