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Cell-type-specific CCK2 receptor signaling underlies the cholecystokinin-mediated selective excitation of hippocampal parvalbumin-positive fast-spiking basket cells

Parvalbumin-positive (PV+) fast-spiking basket cells are thought to play key roles in network functions related to precise time keeping during behaviorally relevant hippocampal synchronous oscillations. Although they express relatively few receptors for neuromodulators, the highly abundant and funct... Full description

Journal Title: The Journal of neuroscience : the official journal of the Society for Neuroscience 27 July 2011, Vol.31(30), pp.10993-1002
Main Author: Lee, Soo Yeun
Other Authors: Földy, Csaba , Szabadics, János , Soltesz, Ivan
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1529-2401 ; PMID: 21795548 Version:1 ; DOI: 10.1523/JNEUROSCI.1970-11.2011
Link: http://pubmed.gov/21795548
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recordid: medline21795548
title: Cell-type-specific CCK2 receptor signaling underlies the cholecystokinin-mediated selective excitation of hippocampal parvalbumin-positive fast-spiking basket cells
format: Article
creator:
  • Lee, Soo Yeun
  • Földy, Csaba
  • Szabadics, János
  • Soltesz, Ivan
subjects:
  • Action Potentials -- Drug Effects
  • Cholecystokinin -- Pharmacology
  • Hippocampus -- Cytology
  • Neurons -- Drug Effects
  • Parvalbumins -- Metabolism
  • Receptor, Cholecystokinin B -- Metabolism
ispartof: The Journal of neuroscience : the official journal of the Society for Neuroscience, 27 July 2011, Vol.31(30), pp.10993-1002
description: Parvalbumin-positive (PV+) fast-spiking basket cells are thought to play key roles in network functions related to precise time keeping during behaviorally relevant hippocampal synchronous oscillations. Although they express relatively few receptors for neuromodulators, the highly abundant and functionally important neuropeptide cholecystokinin (CCK) is able to selectively depolarize PV+ basket cells, making these cells sensitive biosensors for CCK. However, the molecular mechanisms underlying the CCK-induced selective and powerful excitation of PV+ basket cells are not understood. We used single and paired patch-clamp recordings in acute rat hippocampal slices, in combination with post hoc identification of the recorded interneurons, to demonstrate that CCK acts via G-protein-coupled CCK2 receptors to engage sharply divergent intracellular pathways to exert its cell-type-selective effects. In contrast to CCK2 receptors on pyramidal cells that signal through the canonical G(q)-PLC pathway...
language: eng
source:
identifier: E-ISSN: 1529-2401 ; PMID: 21795548 Version:1 ; DOI: 10.1523/JNEUROSCI.1970-11.2011
fulltext: fulltext
issn:
  • 15292401
  • 1529-2401
url: Link


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titleCell-type-specific CCK2 receptor signaling underlies the cholecystokinin-mediated selective excitation of hippocampal parvalbumin-positive fast-spiking basket cells
creatorLee, Soo Yeun ; Földy, Csaba ; Szabadics, János ; Soltesz, Ivan
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subjectAction Potentials -- Drug Effects ; Cholecystokinin -- Pharmacology ; Hippocampus -- Cytology ; Neurons -- Drug Effects ; Parvalbumins -- Metabolism ; Receptor, Cholecystokinin B -- Metabolism
descriptionParvalbumin-positive (PV+) fast-spiking basket cells are thought to play key roles in network functions related to precise time keeping during behaviorally relevant hippocampal synchronous oscillations. Although they express relatively few receptors for neuromodulators, the highly abundant and functionally important neuropeptide cholecystokinin (CCK) is able to selectively depolarize PV+ basket cells, making these cells sensitive biosensors for CCK. However, the molecular mechanisms underlying the CCK-induced selective and powerful excitation of PV+ basket cells are not understood. We used single and paired patch-clamp recordings in acute rat hippocampal slices, in combination with post hoc identification of the recorded interneurons, to demonstrate that CCK acts via G-protein-coupled CCK2 receptors to engage sharply divergent intracellular pathways to exert its cell-type-selective effects. In contrast to CCK2 receptors on pyramidal cells that signal through the canonical G(q)-PLC pathway...
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descriptionParvalbumin-positive (PV+) fast-spiking basket cells are thought to play key roles in network functions related to precise time keeping during behaviorally relevant hippocampal synchronous oscillations. Although they express relatively few receptors for neuromodulators, the highly abundant and functionally important neuropeptide cholecystokinin (CCK) is able to selectively depolarize PV+ basket cells, making these cells sensitive biosensors for CCK. However, the molecular mechanisms underlying the CCK-induced selective and powerful excitation of PV+ basket cells are not understood. We used single and paired patch-clamp recordings in acute rat hippocampal slices, in combination with post hoc identification of the recorded interneurons, to demonstrate that CCK acts via G-protein-coupled CCK2 receptors to engage sharply divergent intracellular pathways to exert its cell-type-selective effects. In contrast to CCK2 receptors on pyramidal cells that signal through the canonical G(q)-PLC pathway...
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abstractParvalbumin-positive (PV+) fast-spiking basket cells are thought to play key roles in network functions related to precise time keeping during behaviorally relevant hippocampal synchronous oscillations. Although they express relatively few receptors for neuromodulators, the highly abundant and functionally important neuropeptide cholecystokinin (CCK) is able to selectively depolarize PV+ basket cells, making these cells sensitive biosensors for CCK. However, the molecular mechanisms underlying the CCK-induced selective and powerful excitation of PV+ basket cells are not understood. We used single and paired patch-clamp recordings in acute rat hippocampal slices, in combination with post hoc identification of the recorded interneurons, to demonstrate that CCK acts via G-protein-coupled CCK2 receptors to engage sharply divergent intracellular pathways to exert its cell-type-selective effects. In contrast to CCK2 receptors on pyramidal cells that signal through the canonical G(q)-PLC pathway...
doi10.1523/JNEUROSCI.1970-11.2011
pmid21795548
date2011-07-27