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A genome-wide association study identifies two new risk loci for Graves' disease

Graves' disease is a common autoimmune disorder characterized by thyroid stimulating hormone receptor autoantibodies (TRAb) and hyperthyroidism. To investigate the genetic architecture of Graves' disease, we conducted a genome-wide association study in 1,536 individuals with Graves' disease (cases)... Full description

Journal Title: Nature genetics 14 August 2011, Vol.43(9), pp.897-901
Main Author: Chu, Xun
Other Authors: Pan, Chun-Ming , Zhao, Shuang-Xia , Liang, Jun , Gao, Guan-Qi , Zhang, Xiao-Mei , Yuan, Guo-Yue , Li, Chang-Gui , Xue, Li-Qiong , Shen, Min , Liu, Wei , Xie, Fang , Yang, Shao-Ying , Wang, Hai-Feng , Shi, Jing-Yi , Sun, Wei-Wei , Du, Wen-Hua , Zuo, Chun-Lin , Shi, Jin-Xiu , Liu, Bing-Li , Guo, Cui-Cui , Zhan, Ming , Gu, Zhao-Hui , Zhang, Xiao-Na , Sun, Fei , Wang, Zhi-Quan , Song, Zhi-Yi , Zou, Cai-Yan , Sun, Wei-Hua , Guo, Ting , Cao, Huang-Ming , Ma, Jun-Hua , Han, Bing , Li, Ping , Jiang, He , Huang, Qiu-Hua , Liang, Liming , Liu, Li-Bin , Chen, Gang , Su, Qing , Peng, Yong-De , Zhao, Jia-Jun , Ning, Guang , Chen, Zhu , Chen, Jia-Lun , Chen, Sai-Juan , Huang, Wei , Song, Huai-Dong
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1546-1718 ; PMID: 21841780 Version:1 ; DOI: 10.1038/ng.898
Link: http://pubmed.gov/21841780
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title: A genome-wide association study identifies two new risk loci for Graves' disease
format: Article
creator:
  • Chu, Xun
  • Pan, Chun-Ming
  • Zhao, Shuang-Xia
  • Liang, Jun
  • Gao, Guan-Qi
  • Zhang, Xiao-Mei
  • Yuan, Guo-Yue
  • Li, Chang-Gui
  • Xue, Li-Qiong
  • Shen, Min
  • Liu, Wei
  • Xie, Fang
  • Yang, Shao-Ying
  • Wang, Hai-Feng
  • Shi, Jing-Yi
  • Sun, Wei-Wei
  • Du, Wen-Hua
  • Zuo, Chun-Lin
  • Shi, Jin-Xiu
  • Liu, Bing-Li
  • Guo, Cui-Cui
  • Zhan, Ming
  • Gu, Zhao-Hui
  • Zhang, Xiao-Na
  • Sun, Fei
  • Wang, Zhi-Quan
  • Song, Zhi-Yi
  • Zou, Cai-Yan
  • Sun, Wei-Hua
  • Guo, Ting
  • Cao, Huang-Ming
  • Ma, Jun-Hua
  • Han, Bing
  • Li, Ping
  • Jiang, He
  • Huang, Qiu-Hua
  • Liang, Liming
  • Liu, Li-Bin
  • Chen, Gang
  • Su, Qing
  • Peng, Yong-De
  • Zhao, Jia-Jun
  • Ning, Guang
  • Chen, Zhu
  • Chen, Jia-Lun
  • Chen, Sai-Juan
  • Huang, Wei
  • Song, Huai-Dong
subjects:
  • Genetic Loci
  • Genetic Predisposition to Disease
  • Graves Disease -- Genetics
  • Receptors, Thyrotropin -- Genetics
ispartof: Nature genetics, 14 August 2011, Vol.43(9), pp.897-901
description: Graves' disease is a common autoimmune disorder characterized by thyroid stimulating hormone receptor autoantibodies (TRAb) and hyperthyroidism. To investigate the genetic architecture of Graves' disease, we conducted a genome-wide association study in 1,536 individuals with Graves' disease (cases) and 1,516 controls. We further evaluated a group of associated SNPs in a second set of 3,994 cases and 3,510 controls. We confirmed four previously reported loci (in the major histocompatibility complex, TSHR, CTLA4 and FCRL3) and identified two new susceptibility loci (the RNASET2-FGFR1OP-CCR6 region at 6q27 (P(combined) = 6.85 × 10(-10) for rs9355610) and an intergenic region at 4p14 (P(combined) = 1.08 × 10(-13) for rs6832151)). These newly associated SNPs were correlated with the expression levels of RNASET2 at 6q27, of CHRNA9 and of a previously uncharacterized gene at 4p14, respectively. Moreover, we identified strong associations of TSHR and major histocompatibility complex class II variants with persistently TRAb-positive Graves' disease.
language: eng
source:
identifier: E-ISSN: 1546-1718 ; PMID: 21841780 Version:1 ; DOI: 10.1038/ng.898
fulltext: fulltext
issn:
  • 15461718
  • 1546-1718
url: Link


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titleA genome-wide association study identifies two new risk loci for Graves' disease
creatorChu, Xun ; Pan, Chun-Ming ; Zhao, Shuang-Xia ; Liang, Jun ; Gao, Guan-Qi ; Zhang, Xiao-Mei ; Yuan, Guo-Yue ; Li, Chang-Gui ; Xue, Li-Qiong ; Shen, Min ; Liu, Wei ; Xie, Fang ; Yang, Shao-Ying ; Wang, Hai-Feng ; Shi, Jing-Yi ; Sun, Wei-Wei ; Du, Wen-Hua ; Zuo, Chun-Lin ; Shi, Jin-Xiu ; Liu, Bing-Li ; Guo, Cui-Cui ; Zhan, Ming ; Gu, Zhao-Hui ; Zhang, Xiao-Na ; Sun, Fei ; Wang, Zhi-Quan ; Song, Zhi-Yi ; Zou, Cai-Yan ; Sun, Wei-Hua ; Guo, Ting ; Cao, Huang-Ming ; Ma, Jun-Hua ; Han, Bing ; Li, Ping ; Jiang, He ; Huang, Qiu-Hua ; Liang, Liming ; Liu, Li-Bin ; Chen, Gang ; Su, Qing ; Peng, Yong-De ; Zhao, Jia-Jun ; Ning, Guang ; Chen, Zhu ; Chen, Jia-Lun ; Chen, Sai-Juan ; Huang, Wei ; Song, Huai-Dong
ispartofNature genetics, 14 August 2011, Vol.43(9), pp.897-901
identifier
subjectGenetic Loci ; Genetic Predisposition to Disease ; Graves Disease -- Genetics ; Receptors, Thyrotropin -- Genetics
descriptionGraves' disease is a common autoimmune disorder characterized by thyroid stimulating hormone receptor autoantibodies (TRAb) and hyperthyroidism. To investigate the genetic architecture of Graves' disease, we conducted a genome-wide association study in 1,536 individuals with Graves' disease (cases) and 1,516 controls. We further evaluated a group of associated SNPs in a second set of 3,994 cases and 3,510 controls. We confirmed four previously reported loci (in the major histocompatibility complex, TSHR, CTLA4 and FCRL3) and identified two new susceptibility loci (the RNASET2-FGFR1OP-CCR6 region at 6q27 (P(combined) = 6.85 × 10(-10) for rs9355610) and an intergenic region at 4p14 (P(combined) = 1.08 × 10(-13) for rs6832151)). These newly associated SNPs were correlated with the expression levels of RNASET2 at 6q27, of CHRNA9 and of a previously uncharacterized gene at 4p14, respectively. Moreover, we identified strong associations of TSHR and major histocompatibility complex class II variants with persistently TRAb-positive Graves' disease.
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titleA genome-wide association study identifies two new risk loci for Graves' disease
descriptionGraves' disease is a common autoimmune disorder characterized by thyroid stimulating hormone receptor autoantibodies (TRAb) and hyperthyroidism. To investigate the genetic architecture of Graves' disease, we conducted a genome-wide association study in 1,536 individuals with Graves' disease (cases) and 1,516 controls. We further evaluated a group of associated SNPs in a second set of 3,994 cases and 3,510 controls. We confirmed four previously reported loci (in the major histocompatibility complex, TSHR, CTLA4 and FCRL3) and identified two new susceptibility loci (the RNASET2-FGFR1OP-CCR6 region at 6q27 (P(combined) = 6.85 × 10(-10) for rs9355610) and an intergenic region at 4p14 (P(combined) = 1.08 × 10(-13) for rs6832151)). These newly associated SNPs were correlated with the expression levels of RNASET2 at 6q27, of CHRNA9 and of a previously uncharacterized gene at 4p14, respectively. Moreover, we identified strong associations of TSHR and major histocompatibility complex class II variants with persistently TRAb-positive Graves' disease.
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abstractGraves' disease is a common autoimmune disorder characterized by thyroid stimulating hormone receptor autoantibodies (TRAb) and hyperthyroidism. To investigate the genetic architecture of Graves' disease, we conducted a genome-wide association study in 1,536 individuals with Graves' disease (cases) and 1,516 controls. We further evaluated a group of associated SNPs in a second set of 3,994 cases and 3,510 controls. We confirmed four previously reported loci (in the major histocompatibility complex, TSHR, CTLA4 and FCRL3) and identified two new susceptibility loci (the RNASET2-FGFR1OP-CCR6 region at 6q27 (P(combined) = 6.85 × 10(-10) for rs9355610) and an intergenic region at 4p14 (P(combined) = 1.08 × 10(-13) for rs6832151)). These newly associated SNPs were correlated with the expression levels of RNASET2 at 6q27, of CHRNA9 and of a previously uncharacterized gene at 4p14, respectively. Moreover, we identified strong associations of TSHR and major histocompatibility complex class II variants with persistently TRAb-positive Graves' disease.
doi10.1038/ng.898
pmid21841780
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date2011-08-14