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Long-term prognostic value of coronary flow velocity reserve in renal transplant recipients

In this prospective study, we sought to investigate the long-term prognostic value of coronary flow reserve (CFR) and carotid intima media thickness (IMT) estimates in renal transplant recipients without known coronary artery disease. The 20 renal transplant recipients included in this study underwe... Full description

Journal Title: Transplantation proceedings September 2011, Vol.43(7), pp.2612-6
Main Author: Akagun, T
Other Authors: Caliskan, Y , Alpay, N , Ozkok, A , Yazici, H , Polat, N , Guz, G , Oflaz, H , Turkmen, A , Sukru Sever, M
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1873-2623 ; PMID: 21911133 Version:1 ; DOI: 10.1016/j.transproceed.2011.05.046
Link: http://pubmed.gov/21911133
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recordid: medline21911133
title: Long-term prognostic value of coronary flow velocity reserve in renal transplant recipients
format: Article
creator:
  • Akagun, T
  • Caliskan, Y
  • Alpay, N
  • Ozkok, A
  • Yazici, H
  • Polat, N
  • Guz, G
  • Oflaz, H
  • Turkmen, A
  • Sukru Sever, M
subjects:
  • Kidney Transplantation
  • Coronary Vessels -- Physiopathology
ispartof: Transplantation proceedings, September 2011, Vol.43(7), pp.2612-6
description: In this prospective study, we sought to investigate the long-term prognostic value of coronary flow reserve (CFR) and carotid intima media thickness (IMT) estimates in renal transplant recipients without known coronary artery disease. The 20 renal transplant recipients included in this study underwent CFR recordings performed by trans-thoracic Doppler echocardiography (TTDE) and carotid IMT measured by carotid Doppler ultrasonography. During a 3-year follow-up only one patient experienced a cardiac event. The baseline CFR and carotid IMT values of the patients were 1.77 ± 0.47 and 0.67 ± 0.15 mm, respectively. After 3 years of follow-up, there were no significant differences compared with baseline measurements with regard to CFR and IMT values. CFR values at the third year of follow-up showed significant correlation with age as well as IMT at baseline and at the third year. Upon multivariate analysis, baseline carotid IMT (β = -0.562; P = .05) was a significant independent predictor of CFR at the third year. Carotid IMT showed a greater predictive value for impaired CFR in renal transplant recipients. CFR was not an independent predictor for cardiovascular events among renal transplant recipients within the first 3 years of follow-up measurements.
language: eng
source:
identifier: E-ISSN: 1873-2623 ; PMID: 21911133 Version:1 ; DOI: 10.1016/j.transproceed.2011.05.046
fulltext: fulltext
issn:
  • 18732623
  • 1873-2623
url: Link


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titleLong-term prognostic value of coronary flow velocity reserve in renal transplant recipients
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subjectKidney Transplantation ; Coronary Vessels -- Physiopathology
descriptionIn this prospective study, we sought to investigate the long-term prognostic value of coronary flow reserve (CFR) and carotid intima media thickness (IMT) estimates in renal transplant recipients without known coronary artery disease. The 20 renal transplant recipients included in this study underwent CFR recordings performed by trans-thoracic Doppler echocardiography (TTDE) and carotid IMT measured by carotid Doppler ultrasonography. During a 3-year follow-up only one patient experienced a cardiac event. The baseline CFR and carotid IMT values of the patients were 1.77 ± 0.47 and 0.67 ± 0.15 mm, respectively. After 3 years of follow-up, there were no significant differences compared with baseline measurements with regard to CFR and IMT values. CFR values at the third year of follow-up showed significant correlation with age as well as IMT at baseline and at the third year. Upon multivariate analysis, baseline carotid IMT (β = -0.562; P = .05) was a significant independent predictor of CFR at the third year. Carotid IMT showed a greater predictive value for impaired CFR in renal transplant recipients. CFR was not an independent predictor for cardiovascular events among renal transplant recipients within the first 3 years of follow-up measurements.
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2During a 3-year follow-up only one patient experienced a cardiac event. The baseline CFR and carotid IMT values of the patients were 1.77 ± 0.47 and 0.67 ± 0.15 mm, respectively. After 3 years of follow-up, there were no significant differences compared with baseline measurements with regard to CFR and IMT values. CFR values at the third year of follow-up showed significant correlation with age as well as IMT at baseline and at the third year. Upon multivariate analysis, baseline carotid IMT (β = -0.562; P = .05) was a significant independent predictor of CFR at the third year.
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abstractIn this prospective study, we sought to investigate the long-term prognostic value of coronary flow reserve (CFR) and carotid intima media thickness (IMT) estimates in renal transplant recipients without known coronary artery disease.
doi10.1016/j.transproceed.2011.05.046
pmid21911133
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date2011-09