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Gold nanoparticles in the clinical laboratory: principles of preparation and applications

In order to meet the challenges of effective healthcare, the clinical laboratory is constantly striving to improve testing sensitivity while reducing the required time and cost. Gold nanoparticles (AuNPs) are proposed as one of the most promising tools to meet such goals. They have unique optophysic... Full description

Journal Title: Clinical chemistry and laboratory medicine 06 October 2011, Vol.50(2), pp.193-209
Main Author: Azzazy, Hassan M E
Other Authors: Mansour, Mai M H , Samir, Tamer M , Franco, Ricardo
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1437-4331 ; PMID: 21973106 Version:1 ; DOI: 10.1515/CCLM.2011.732
Link: http://pubmed.gov/21973106
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recordid: medline21973106
title: Gold nanoparticles in the clinical laboratory: principles of preparation and applications
format: Article
creator:
  • Azzazy, Hassan M E
  • Mansour, Mai M H
  • Samir, Tamer M
  • Franco, Ricardo
subjects:
  • Biomarkers
  • Biological Assay -- Methods
  • Gold -- Chemistry
  • Metal Nanoparticles -- Chemistry
ispartof: Clinical chemistry and laboratory medicine, 06 October 2011, Vol.50(2), pp.193-209
description: In order to meet the challenges of effective healthcare, the clinical laboratory is constantly striving to improve testing sensitivity while reducing the required time and cost. Gold nanoparticles (AuNPs) are proposed as one of the most promising tools to meet such goals. They have unique optophysical properties which enable sensitive detection of biomarkers, and are easily amenable to modification for use in different assay formats including immunoassays and molecular assays. Additionally, their preparation is relatively simple and their detection methods are quite versatile. AuNPs are showing substantial promise for effective practical applications and commercial utilization is already underway. This article covers the principles of preparation of AuNPs and their use for development of different diagnostic platforms.
language: eng
source:
identifier: E-ISSN: 1437-4331 ; PMID: 21973106 Version:1 ; DOI: 10.1515/CCLM.2011.732
fulltext: fulltext
issn:
  • 14374331
  • 1437-4331
url: Link


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descriptionIn order to meet the challenges of effective healthcare, the clinical laboratory is constantly striving to improve testing sensitivity while reducing the required time and cost. Gold nanoparticles (AuNPs) are proposed as one of the most promising tools to meet such goals. They have unique optophysical properties which enable sensitive detection of biomarkers, and are easily amenable to modification for use in different assay formats including immunoassays and molecular assays. Additionally, their preparation is relatively simple and their detection methods are quite versatile. AuNPs are showing substantial promise for effective practical applications and commercial utilization is already underway. This article covers the principles of preparation of AuNPs and their use for development of different diagnostic platforms.
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abstractIn order to meet the challenges of effective healthcare, the clinical laboratory is constantly striving to improve testing sensitivity while reducing the required time and cost. Gold nanoparticles (AuNPs) are proposed as one of the most promising tools to meet such goals. They have unique optophysical properties which enable sensitive detection of biomarkers, and are easily amenable to modification for use in different assay formats including immunoassays and molecular assays. Additionally, their preparation is relatively simple and their detection methods are quite versatile. AuNPs are showing substantial promise for effective practical applications and commercial utilization is already underway. This article covers the principles of preparation of AuNPs and their use for development of different diagnostic platforms.
doi10.1515/CCLM.2011.732
pmid21973106
date2011-10-06