schliessen

Filtern

 

Bibliotheken

Role of CYP2E1 genotypes in susceptibility to colorectal cancer in the Kashmiri population

Cytochrome P450 2E1 (CYP2E1) is a key enzyme involved in the metabolic activation of procarcinogens such as N-nitrosoamines and low-molecular-weight organic compounds. The main aim of this study was to determine whether CYP450 2E1 polymorphisms are associated with the risk of colorectal cancer (CRC)... Full description

Journal Title: Human genomics October 2011, Vol.5(6), pp.530-7
Main Author: Sameer, A Syed
Other Authors: Nissar, Saniya , Qadri, Qurteeba , Alam, Shafia , Baba, Shahid Mudasir , Siddiqi, Mushtaq A
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1479-7364 ; PMID: 22155602 Version:1
Link: http://pubmed.gov/22155602
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: medline22155602
title: Role of CYP2E1 genotypes in susceptibility to colorectal cancer in the Kashmiri population
format: Article
creator:
  • Sameer, A Syed
  • Nissar, Saniya
  • Qadri, Qurteeba
  • Alam, Shafia
  • Baba, Shahid Mudasir
  • Siddiqi, Mushtaq A
subjects:
  • Genetic Predisposition to Disease
  • Colorectal Neoplasms -- Genetics
  • Cytochrome P-450 Cyp2e1 -- Genetics
  • Polymorphism, Genetic -- Genetics
ispartof: Human genomics, October 2011, Vol.5(6), pp.530-7
description: Cytochrome P450 2E1 (CYP2E1) is a key enzyme involved in the metabolic activation of procarcinogens such as N-nitrosoamines and low-molecular-weight organic compounds. The main aim of this study was to determine whether CYP450 2E1 polymorphisms are associated with the risk of colorectal cancer (CRC). We investigated the genotype distribution of the CYP2E1 gene RsaI and a 96-base pair (bp) insertion in 86 CRC cases in comparison with 160 healthy subjects. We found the frequency of the CYP2E1 RsaI genotype to be 53.5 per cent (46/86) for c1/c1, 17.4 per cent (15/86) for c1/c2 and 29.1 per cent (25/86) for c2/c2, and the CYP2E1 98-bp insertion frequencies to be 63.9 per cent (55/86) for non-insertion (i/i), 22.1 per cent (19/86) for heterozygous insertion (i/I) and 36.0 per cent (12/86) for homozygous insertion (I/I) among CRC cases. We also found the CYP2E1 RsaI c2/c2 and CYP2E1 98-bp heterozygous i/I genotypes to be significantly associated with an increased risk of CRC (p = 0.01). We suggest...
language: eng
source:
identifier: E-ISSN: 1479-7364 ; PMID: 22155602 Version:1
fulltext: fulltext
issn:
  • 14797364
  • 1479-7364
url: Link


@attributes
ID665800589
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordid22155602
sourceidmedline
recordidTN_medline22155602
sourceformatXML
sourcesystemPC
pqid911934599
display
typearticle
titleRole of CYP2E1 genotypes in susceptibility to colorectal cancer in the Kashmiri population
creatorSameer, A Syed ; Nissar, Saniya ; Qadri, Qurteeba ; Alam, Shafia ; Baba, Shahid Mudasir ; Siddiqi, Mushtaq A
ispartofHuman genomics, October 2011, Vol.5(6), pp.530-7
identifierE-ISSN: 1479-7364 ; PMID: 22155602 Version:1
subjectGenetic Predisposition to Disease ; Colorectal Neoplasms -- Genetics ; Cytochrome P-450 Cyp2e1 -- Genetics ; Polymorphism, Genetic -- Genetics
descriptionCytochrome P450 2E1 (CYP2E1) is a key enzyme involved in the metabolic activation of procarcinogens such as N-nitrosoamines and low-molecular-weight organic compounds. The main aim of this study was to determine whether CYP450 2E1 polymorphisms are associated with the risk of colorectal cancer (CRC). We investigated the genotype distribution of the CYP2E1 gene RsaI and a 96-base pair (bp) insertion in 86 CRC cases in comparison with 160 healthy subjects. We found the frequency of the CYP2E1 RsaI genotype to be 53.5 per cent (46/86) for c1/c1, 17.4 per cent (15/86) for c1/c2 and 29.1 per cent (25/86) for c2/c2, and the CYP2E1 98-bp insertion frequencies to be 63.9 per cent (55/86) for non-insertion (i/i), 22.1 per cent (19/86) for heterozygous insertion (i/I) and 36.0 per cent (12/86) for homozygous insertion (I/I) among CRC cases. We also found the CYP2E1 RsaI c2/c2 and CYP2E1 98-bp heterozygous i/I genotypes to be significantly associated with an increased risk of CRC (p = 0.01). We suggest...
languageeng
source
version5
lds50peer_reviewed
links
openurl$$Topenurl_article
backlink$$Uhttp://pubmed.gov/22155602$$EView_this_record_in_MEDLINE/PubMed
openurlfulltext$$Topenurlfull_article
addlink$$Uhttp://exlibris-pub.s3.amazonaws.com/aboutMedline.html$$EView_the_MEDLINE/PubMed_Copyright_Statement
search
creatorcontrib
0Sameer, A Syed
1Nissar, Saniya
2Qadri, Qurteeba
3Alam, Shafia
4Baba, Shahid Mudasir
5Siddiqi, Mushtaq A
titleRole of CYP2E1 genotypes in susceptibility to colorectal cancer in the Kashmiri population
descriptionCytochrome P450 2E1 (CYP2E1) is a key enzyme involved in the metabolic activation of procarcinogens such as N-nitrosoamines and low-molecular-weight organic compounds. The main aim of this study was to determine whether CYP450 2E1 polymorphisms are associated with the risk of colorectal cancer (CRC). We investigated the genotype distribution of the CYP2E1 gene RsaI and a 96-base pair (bp) insertion in 86 CRC cases in comparison with 160 healthy subjects. We found the frequency of the CYP2E1 RsaI genotype to be 53.5 per cent (46/86) for c1/c1, 17.4 per cent (15/86) for c1/c2 and 29.1 per cent (25/86) for c2/c2, and the CYP2E1 98-bp insertion frequencies to be 63.9 per cent (55/86) for non-insertion (i/i), 22.1 per cent (19/86) for heterozygous insertion (i/I) and 36.0 per cent (12/86) for homozygous insertion (I/I) among CRC cases. We also found the CYP2E1 RsaI c2/c2 and CYP2E1 98-bp heterozygous i/I genotypes to be significantly associated with an increased risk of CRC (p = 0.01). We suggest...
subject
0Genetic Predisposition to Disease
1Colorectal Neoplasms -- Genetics
2Cytochrome P-450 Cyp2e1 -- Genetics
3Polymorphism, Genetic -- Genetics
general
022155602
1English
2MEDLINE/PubMed (U.S. National Library of Medicine)
3MEDLINE/PubMed (NLM)
sourceidmedline
recordidmedline22155602
issn
014797364
11479-7364
rsrctypearticle
creationdate2011
addtitleHuman genomics
searchscope
0medline
1nlm_medline
2MEDLINE
scope
0medline
1nlm_medline
2MEDLINE
lsr41201110
citationpf 530 vol 5 issue 6
startdate20111001
enddate20111031
lsr30VSR-Enriched:[doi, pqid, pages]
sort
titleRole of CYP2E1 genotypes in susceptibility to colorectal cancer in the Kashmiri population
authorSameer, A Syed ; Nissar, Saniya ; Qadri, Qurteeba ; Alam, Shafia ; Baba, Shahid Mudasir ; Siddiqi, Mushtaq A
creationdate20111000
lso0120111000
facets
frbrgroupid3300612093452550843
frbrtype5
newrecords20190701
languageeng
creationdate2011
topic
0Genetic Predisposition to Disease
1Colorectal Neoplasms–Genetics
2Cytochrome P-450 Cyp2e1–Genetics
3Polymorphism, Genetic–Genetics
collectionMEDLINE/PubMed (NLM)
prefilterarticles
rsrctypearticles
creatorcontrib
0Sameer, A Syed
1Nissar, Saniya
2Qadri, Qurteeba
3Alam, Shafia
4Baba, Shahid Mudasir
5Siddiqi, Mushtaq A
jtitleHuman Genomics
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
aulast
0Sameer
1Nissar
2Qadri
3Alam
4Baba
5Siddiqi
aufirst
0A Syed
1Saniya
2Qurteeba
3Shafia
4Shahid Mudasir
5Mushtaq A
au
0Sameer, A Syed
1Nissar, Saniya
2Qadri, Qurteeba
3Alam, Shafia
4Baba, Shahid Mudasir
5Siddiqi, Mushtaq A
atitleRole of CYP2E1 genotypes in susceptibility to colorectal cancer in the Kashmiri population
jtitleHuman genomics
risdate201110
volume5
issue6
spage530
pages530-537
issn1473-9542
eissn1479-7364
formatjournal
genrearticle
ristypeJOUR
abstractCytochrome P450 2E1 (CYP2E1) is a key enzyme involved in the metabolic activation of procarcinogens such as N-nitrosoamines and low-molecular-weight organic compounds. The main aim of this study was to determine whether CYP450 2E1 polymorphisms are associated with the risk of colorectal cancer (CRC). We investigated the genotype distribution of the CYP2E1 gene RsaI and a 96-base pair (bp) insertion in 86 CRC cases in comparison with 160 healthy subjects. We found the frequency of the CYP2E1 RsaI genotype to be 53.5 per cent (46/86) for c1/c1, 17.4 per cent (15/86) for c1/c2 and 29.1 per cent (25/86) for c2/c2, and the CYP2E1 98-bp insertion frequencies to be 63.9 per cent (55/86) for non-insertion (i/i), 22.1 per cent (19/86) for heterozygous insertion (i/I) and 36.0 per cent (12/86) for homozygous insertion (I/I) among CRC cases. We also found the CYP2E1 RsaI c2/c2 and CYP2E1 98-bp heterozygous i/I genotypes to be significantly associated with an increased risk of CRC (p = 0.01). We suggest...
pmid22155602
doi10.1186/1479-7364-5-6-530
date2011-10