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Effect of silk fibroin peptide derived from silkworm Bombyx mori on the anti-inflammatory effect of Tat-SOD in a mice edema model

We investigated whether silk fibroin peptide derived from the silkworm, Bombyx mori, could inhibit inflammation and enhance the anti-inflammatory activity of Tat-superoxide dismutase (Tat-SOD), which was previously reported to effectively penetrate various cells and tissues and exert anti-oxidative... Full description

Journal Title: BMB reports December 2011, Vol.44(12), pp.787-92
Main Author: Kim, Dae Won
Other Authors: Hwang, Hyun Sook , Kim, Duk-Soo , Sheen, Seung Hoon , Heo, Dong Hwa , Hwang, Gyojun , Kang, Suk Hyung , Kweon, Haeyong , Jo, You-Young , Kang, Seok Woo , Lee, Kwang-Gill , Park, Kye Won , Han, Kyu Hyung , Park, Jinseu , Eum, Won Sik , Cho, Yong-Jun , Choi, Hyun Chul , Choi, Soo Young
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1976-670X ; PMID: 22189681 Version:1
Link: http://pubmed.gov/22189681
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recordid: medline22189681
title: Effect of silk fibroin peptide derived from silkworm Bombyx mori on the anti-inflammatory effect of Tat-SOD in a mice edema model
format: Article
creator:
  • Kim, Dae Won
  • Hwang, Hyun Sook
  • Kim, Duk-Soo
  • Sheen, Seung Hoon
  • Heo, Dong Hwa
  • Hwang, Gyojun
  • Kang, Suk Hyung
  • Kweon, Haeyong
  • Jo, You-Young
  • Kang, Seok Woo
  • Lee, Kwang-Gill
  • Park, Kye Won
  • Han, Kyu Hyung
  • Park, Jinseu
  • Eum, Won Sik
  • Cho, Yong-Jun
  • Choi, Hyun Chul
  • Choi, Soo Young
subjects:
  • Disease Models, Animal
  • Anti-Inflammatory Agents, Non-Steroidal -- Therapeutic Use
  • Edema -- Drug Therapy
  • Fibroins -- Chemistry
  • Gene Products, Tat -- Metabolism
  • Peptides -- Pharmacology
  • Superoxide Dismutase -- Therapeutic Use
ispartof: BMB reports, December 2011, Vol.44(12), pp.787-92
description: We investigated whether silk fibroin peptide derived from the silkworm, Bombyx mori, could inhibit inflammation and enhance the anti-inflammatory activity of Tat-superoxide dismutase (Tat-SOD), which was previously reported to effectively penetrate various cells and tissues and exert anti-oxidative activity in a mouse model of inflammation. Inflammation was induced by topical treatment of mouse ears with 12-O-tetradecanoylphorbol-13-acetate (TPA). Histological, Western blot, and reverse transcription-polymerase chain reaction data demonstrated that silk fibroin peptide or Tat-SOD alone could suppress elevated levels of cyclooxygenase-2, interleukin-6, interleukin-1beta, and tumor necrosis factor-alpha induced by TPA. Moreover, silk fibroin peptide significantly enhanced the anti-inflammatory activity of Tat-SOD, although it had no influence on in vitro and in vivo transduction of Tat-SOD. Silk fibroin peptide exhibited anti- inflammatory activity in a mice model of inflammation. Therefore,...
language: eng
source:
identifier: E-ISSN: 1976-670X ; PMID: 22189681 Version:1
fulltext: fulltext
issn:
  • 1976670X
  • 1976-670X
url: Link


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titleEffect of silk fibroin peptide derived from silkworm Bombyx mori on the anti-inflammatory effect of Tat-SOD in a mice edema model
creatorKim, Dae Won ; Hwang, Hyun Sook ; Kim, Duk-Soo ; Sheen, Seung Hoon ; Heo, Dong Hwa ; Hwang, Gyojun ; Kang, Suk Hyung ; Kweon, Haeyong ; Jo, You-Young ; Kang, Seok Woo ; Lee, Kwang-Gill ; Park, Kye Won ; Han, Kyu Hyung ; Park, Jinseu ; Eum, Won Sik ; Cho, Yong-Jun ; Choi, Hyun Chul ; Choi, Soo Young
ispartofBMB reports, December 2011, Vol.44(12), pp.787-92
identifierE-ISSN: 1976-670X ; PMID: 22189681 Version:1
subjectDisease Models, Animal ; Anti-Inflammatory Agents, Non-Steroidal -- Therapeutic Use ; Edema -- Drug Therapy ; Fibroins -- Chemistry ; Gene Products, Tat -- Metabolism ; Peptides -- Pharmacology ; Superoxide Dismutase -- Therapeutic Use
descriptionWe investigated whether silk fibroin peptide derived from the silkworm, Bombyx mori, could inhibit inflammation and enhance the anti-inflammatory activity of Tat-superoxide dismutase (Tat-SOD), which was previously reported to effectively penetrate various cells and tissues and exert anti-oxidative activity in a mouse model of inflammation. Inflammation was induced by topical treatment of mouse ears with 12-O-tetradecanoylphorbol-13-acetate (TPA). Histological, Western blot, and reverse transcription-polymerase chain reaction data demonstrated that silk fibroin peptide or Tat-SOD alone could suppress elevated levels of cyclooxygenase-2, interleukin-6, interleukin-1beta, and tumor necrosis factor-alpha induced by TPA. Moreover, silk fibroin peptide significantly enhanced the anti-inflammatory activity of Tat-SOD, although it had no influence on in vitro and in vivo transduction of Tat-SOD. Silk fibroin peptide exhibited anti- inflammatory activity in a mice model of inflammation. Therefore,...
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titleEffect of silk fibroin peptide derived from silkworm Bombyx mori on the anti-inflammatory effect of Tat-SOD in a mice edema model
descriptionWe investigated whether silk fibroin peptide derived from the silkworm, Bombyx mori, could inhibit inflammation and enhance the anti-inflammatory activity of Tat-superoxide dismutase (Tat-SOD), which was previously reported to effectively penetrate various cells and tissues and exert anti-oxidative activity in a mouse model of inflammation. Inflammation was induced by topical treatment of mouse ears with 12-O-tetradecanoylphorbol-13-acetate (TPA). Histological, Western blot, and reverse transcription-polymerase chain reaction data demonstrated that silk fibroin peptide or Tat-SOD alone could suppress elevated levels of cyclooxygenase-2, interleukin-6, interleukin-1beta, and tumor necrosis factor-alpha induced by TPA. Moreover, silk fibroin peptide significantly enhanced the anti-inflammatory activity of Tat-SOD, although it had no influence on in vitro and in vivo transduction of Tat-SOD. Silk fibroin peptide exhibited anti- inflammatory activity in a mice model of inflammation. Therefore,...
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titleEffect of silk fibroin peptide derived from silkworm Bombyx mori on the anti-inflammatory effect of Tat-SOD in a mice edema model
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atitleEffect of silk fibroin peptide derived from silkworm Bombyx mori on the anti-inflammatory effect of Tat-SOD in a mice edema model
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abstractWe investigated whether silk fibroin peptide derived from the silkworm, Bombyx mori, could inhibit inflammation and enhance the anti-inflammatory activity of Tat-superoxide dismutase (Tat-SOD), which was previously reported to effectively penetrate various cells and tissues and exert anti-oxidative activity in a mouse model of inflammation. Inflammation was induced by topical treatment of mouse ears with 12-O-tetradecanoylphorbol-13-acetate (TPA). Histological, Western blot, and reverse transcription-polymerase chain reaction data demonstrated that silk fibroin peptide or Tat-SOD alone could suppress elevated levels of cyclooxygenase-2, interleukin-6, interleukin-1beta, and tumor necrosis factor-alpha induced by TPA. Moreover, silk fibroin peptide significantly enhanced the anti-inflammatory activity of Tat-SOD, although it had no influence on in vitro and in vivo transduction of Tat-SOD. Silk fibroin peptide exhibited anti- inflammatory activity in a mice model of inflammation. Therefore,...
pmid22189681
doi10.5483/BMBRep.2011.44.12.787
date2011-12