schliessen

Filtern

 

Bibliotheken

Sympathetic activation by chemical stimulation of white adipose tissues in rats

Injection of leptin into white adipose tissue (WAT) increases sympathetic outflow. The present study was designed to determine the effects of capsaicin and other chemicals in WAT on the sympathetic outflow and blood pressure and the roles of WAT afferents and hypothalamic paraventricular nucleus (PV... Full description

Journal Title: Journal of applied physiology (Bethesda Md. : 1985), March 2012, Vol.112(6), pp.1008-14
Main Author: Shi, Zhen
Other Authors: Chen, Wei-Wei , Xiong, Xiao-Qing , Han, Ying , Zhou, Ye-Bo , Zhang, Feng , Gao, Xing-Ya , Zhu, Guo-Qing
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1522-1601 ; PMID: 22223453 Version:1 ; DOI: 10.1152/japplphysiol.01164.2011
Link: http://pubmed.gov/22223453
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: medline22223453
title: Sympathetic activation by chemical stimulation of white adipose tissues in rats
format: Article
creator:
  • Shi, Zhen
  • Chen, Wei-Wei
  • Xiong, Xiao-Qing
  • Han, Ying
  • Zhou, Ye-Bo
  • Zhang, Feng
  • Gao, Xing-Ya
  • Zhu, Guo-Qing
subjects:
  • Adipose Tissue, White -- Drug Effects
  • Sympathetic Nervous System -- Drug Effects
ispartof: Journal of applied physiology (Bethesda, Md. : 1985), March 2012, Vol.112(6), pp.1008-14
description: Injection of leptin into white adipose tissue (WAT) increases sympathetic outflow. The present study was designed to determine the effects of capsaicin and other chemicals in WAT on the sympathetic outflow and blood pressure and the roles of WAT afferents and hypothalamic paraventricular nucleus (PVN) in the adipose afferent reflex (AAR). The AAR was induced by injection of capsaicin, bradykinin, adenosine, adenosine triphosphate (ATP), or leptin into inguinal WAT (iWAT) or retroperitoneal WAT (rWAT) in anesthetized rats. The iWAT injection of capsaicin increased the renal sympathetic nerve activity (RSNA) and mean arterial pressure (MAP) but not the heart rate. Bradykinin, adenosine, or leptin but not ATP in the iWAT caused similar effects to capsaicin on the RSNA and MAP. Intravenous, intramuscular, or intradermal injection of capsaicin had no significant effects on the RSNA and MAP. The effects of capsaicin in rWAT were similar to that in iWAT on the RSNA and MAP. Furthermore, injection of capsaicin into the iWAT increased the WAT afferent nerve activities, WAT efferent nerve activity, and brown adipose tissue efferent nerve activity. The iWAT denervation or chemical lesion of the PVN neurons with kainic acid abolished the AAR induced by the iWAT injection of capsaicin. These results indicate that the stimulation of iWAT afferents with capsaicin, bradykinin, adenosine, or leptin reflexly increases the RSNA and blood pressure. The iWAT afferents and the PVN are involved in the AAR induced by capsaicin in the iWAT.
language: eng
source:
identifier: E-ISSN: 1522-1601 ; PMID: 22223453 Version:1 ; DOI: 10.1152/japplphysiol.01164.2011
fulltext: fulltext
issn:
  • 15221601
  • 1522-1601
url: Link


@attributes
ID141571657
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordid22223453
sourceidmedline
recordidTN_medline22223453
sourceformatXML
sourcesystemOther
pqid928909262
display
typearticle
titleSympathetic activation by chemical stimulation of white adipose tissues in rats
creatorShi, Zhen ; Chen, Wei-Wei ; Xiong, Xiao-Qing ; Han, Ying ; Zhou, Ye-Bo ; Zhang, Feng ; Gao, Xing-Ya ; Zhu, Guo-Qing
ispartofJournal of applied physiology (Bethesda, Md. : 1985), March 2012, Vol.112(6), pp.1008-14
identifier
subjectAdipose Tissue, White -- Drug Effects ; Sympathetic Nervous System -- Drug Effects
descriptionInjection of leptin into white adipose tissue (WAT) increases sympathetic outflow. The present study was designed to determine the effects of capsaicin and other chemicals in WAT on the sympathetic outflow and blood pressure and the roles of WAT afferents and hypothalamic paraventricular nucleus (PVN) in the adipose afferent reflex (AAR). The AAR was induced by injection of capsaicin, bradykinin, adenosine, adenosine triphosphate (ATP), or leptin into inguinal WAT (iWAT) or retroperitoneal WAT (rWAT) in anesthetized rats. The iWAT injection of capsaicin increased the renal sympathetic nerve activity (RSNA) and mean arterial pressure (MAP) but not the heart rate. Bradykinin, adenosine, or leptin but not ATP in the iWAT caused similar effects to capsaicin on the RSNA and MAP. Intravenous, intramuscular, or intradermal injection of capsaicin had no significant effects on the RSNA and MAP. The effects of capsaicin in rWAT were similar to that in iWAT on the RSNA and MAP. Furthermore, injection of capsaicin into the iWAT increased the WAT afferent nerve activities, WAT efferent nerve activity, and brown adipose tissue efferent nerve activity. The iWAT denervation or chemical lesion of the PVN neurons with kainic acid abolished the AAR induced by the iWAT injection of capsaicin. These results indicate that the stimulation of iWAT afferents with capsaicin, bradykinin, adenosine, or leptin reflexly increases the RSNA and blood pressure. The iWAT afferents and the PVN are involved in the AAR induced by capsaicin in the iWAT.
languageeng
source
version4
lds50peer_reviewed
links
openurl$$Topenurl_article
backlink$$Uhttp://pubmed.gov/22223453$$EView_this_record_in_MEDLINE/PubMed
openurlfulltext$$Topenurlfull_article
addlink$$Uhttp://exlibris-pub.s3.amazonaws.com/aboutMedline.html$$EView_the_MEDLINE/PubMed_Copyright_Statement
search
creatorcontrib
0Shi, Zhen
1Chen, Wei-Wei
2Xiong, Xiao-Qing
3Han, Ying
4Zhou, Ye-Bo
5Zhang, Feng
6Gao, Xing-Ya
7Zhu, Guo-Qing
titleSympathetic activation by chemical stimulation of white adipose tissues in rats
descriptionInjection of leptin into white adipose tissue (WAT) increases sympathetic outflow. The present study was designed to determine the effects of capsaicin and other chemicals in WAT on the sympathetic outflow and blood pressure and the roles of WAT afferents and hypothalamic paraventricular nucleus (PVN) in the adipose afferent reflex (AAR). The AAR was induced by injection of capsaicin, bradykinin, adenosine, adenosine triphosphate (ATP), or leptin into inguinal WAT (iWAT) or retroperitoneal WAT (rWAT) in anesthetized rats. The iWAT injection of capsaicin increased the renal sympathetic nerve activity (RSNA) and mean arterial pressure (MAP) but not the heart rate. Bradykinin, adenosine, or leptin but not ATP in the iWAT caused similar effects to capsaicin on the RSNA and MAP. Intravenous, intramuscular, or intradermal injection of capsaicin had no significant effects on the RSNA and MAP. The effects of capsaicin in rWAT were similar to that in iWAT on the RSNA and MAP. Furthermore, injection of capsaicin into the iWAT increased the WAT afferent nerve activities, WAT efferent nerve activity, and brown adipose tissue efferent nerve activity. The iWAT denervation or chemical lesion of the PVN neurons with kainic acid abolished the AAR induced by the iWAT injection of capsaicin. These results indicate that the stimulation of iWAT afferents with capsaicin, bradykinin, adenosine, or leptin reflexly increases the RSNA and blood pressure. The iWAT afferents and the PVN are involved in the AAR induced by capsaicin in the iWAT.
subject
0Adipose Tissue, White -- Drug Effects
1Sympathetic Nervous System -- Drug Effects
general
022223453
1English
2MEDLINE/PubMed (U.S. National Library of Medicine)
310.1152/japplphysiol.01164.2011
4MEDLINE/PubMed (NLM)
sourceidmedline
recordidmedline22223453
issn
015221601
11522-1601
rsrctypearticle
creationdate2012
addtitleJournal of applied physiology (Bethesda, Md. : 1985)
searchscope
0medline
1nlm_medline
2MEDLINE
scope
0medline
1nlm_medline
2MEDLINE
lsr41201203
citationpf 1008 vol 112 issue 6
startdate20120301
enddate20120331
lsr30VSR-Enriched:[pages, issn, pqid]
sort
titleSympathetic activation by chemical stimulation of white adipose tissues in rats
authorShi, Zhen ; Chen, Wei-Wei ; Xiong, Xiao-Qing ; Han, Ying ; Zhou, Ye-Bo ; Zhang, Feng ; Gao, Xing-Ya ; Zhu, Guo-Qing
creationdate20120300
lso0120120300
facets
frbrgroupid5347396196135121536
frbrtype5
newrecords20190701
languageeng
creationdate2012
topic
0Adipose Tissue, White–Drug Effects
1Sympathetic Nervous System–Drug Effects
collectionMEDLINE/PubMed (NLM)
prefilterarticles
rsrctypearticles
creatorcontrib
0Shi, Zhen
1Chen, Wei-Wei
2Xiong, Xiao-Qing
3Han, Ying
4Zhou, Ye-Bo
5Zhang, Feng
6Gao, Xing-Ya
7Zhu, Guo-Qing
jtitleJournal Of Applied Physiology (Bethesda, Md. : 1985)
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
aulast
0Shi
1Chen
2Xiong
3Han
4Zhou
5Zhang
6Gao
7Zhu
aufirst
0Zhen
1Wei-Wei
2Xiao-Qing
3Ying
4Ye-Bo
5Feng
6Xing-Ya
7Guo-Qing
au
0Shi, Zhen
1Chen, Wei-Wei
2Xiong, Xiao-Qing
3Han, Ying
4Zhou, Ye-Bo
5Zhang, Feng
6Gao, Xing-Ya
7Zhu, Guo-Qing
atitleSympathetic activation by chemical stimulation of white adipose tissues in rats
jtitleJournal of applied physiology (Bethesda, Md. : 1985)
risdate201203
volume112
issue6
spage1008
pages1008-1014
eissn1522-1601
formatjournal
genrearticle
ristypeJOUR
abstractInjection of leptin into white adipose tissue (WAT) increases sympathetic outflow. The present study was designed to determine the effects of capsaicin and other chemicals in WAT on the sympathetic outflow and blood pressure and the roles of WAT afferents and hypothalamic paraventricular nucleus (PVN) in the adipose afferent reflex (AAR). The AAR was induced by injection of capsaicin, bradykinin, adenosine, adenosine triphosphate (ATP), or leptin into inguinal WAT (iWAT) or retroperitoneal WAT (rWAT) in anesthetized rats. The iWAT injection of capsaicin increased the renal sympathetic nerve activity (RSNA) and mean arterial pressure (MAP) but not the heart rate. Bradykinin, adenosine, or leptin but not ATP in the iWAT caused similar effects to capsaicin on the RSNA and MAP. Intravenous, intramuscular, or intradermal injection of capsaicin had no significant effects on the RSNA and MAP. The effects of capsaicin in rWAT were similar to that in iWAT on the RSNA and MAP. Furthermore, injection of capsaicin into the iWAT increased the WAT afferent nerve activities, WAT efferent nerve activity, and brown adipose tissue efferent nerve activity. The iWAT denervation or chemical lesion of the PVN neurons with kainic acid abolished the AAR induced by the iWAT injection of capsaicin. These results indicate that the stimulation of iWAT afferents with capsaicin, bradykinin, adenosine, or leptin reflexly increases the RSNA and blood pressure. The iWAT afferents and the PVN are involved in the AAR induced by capsaicin in the iWAT.
doi10.1152/japplphysiol.01164.2011
pmid22223453
issn87507587
oafree_for_read
date2012-03