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Systematic identification of type I and type II interferon-induced antiviral factors

Type I and type II interferons (IFNs) are cytokines that establish the cellular antiviral state through the induction of IFN-stimulated genes (ISGs). We sought to understand the basis of the antiviral activity induced by type I and II IFNs in relation to the functions of their ISGs. Based on gene ex... Full description

Journal Title: Proceedings of the National Academy of Sciences of the United States of America 13 March 2012, Vol.109(11), pp.4239-44
Main Author: Liu, Su-Yang
Other Authors: Sanchez, David Jesse , Aliyari, Roghiyh , Lu, Sun , Cheng, Genhong
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1091-6490 ; PMID: 22371602 Version:1 ; DOI: 10.1073/pnas.1114981109
Link: http://pubmed.gov/22371602
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recordid: medline22371602
title: Systematic identification of type I and type II interferon-induced antiviral factors
format: Article
creator:
  • Liu, Su-Yang
  • Sanchez, David Jesse
  • Aliyari, Roghiyh
  • Lu, Sun
  • Cheng, Genhong
subjects:
  • DNA Viruses -- Immunology
  • Interferon Type I -- Immunology
  • Interferon-Gamma -- Immunology
  • Vesiculovirus -- Immunology
ispartof: Proceedings of the National Academy of Sciences of the United States of America, 13 March 2012, Vol.109(11), pp.4239-44
description: Type I and type II interferons (IFNs) are cytokines that establish the cellular antiviral state through the induction of IFN-stimulated genes (ISGs). We sought to understand the basis of the antiviral activity induced by type I and II IFNs in relation to the functions of their ISGs. Based on gene expression studies, we systematically identified antiviral ISGs by performing blinded, functional screens on 288 type I and type II ISGs. We assessed and validated the antiviral activity of these ISGs against an RNA virus, vesicular stomatitis virus (VSV), and a DNA virus, murine gammaherpes virus (MHV-68). Overall, we identified 34 ISGs that elicited an antiviral effect on the replication of either one or both viruses. Fourteen ISGs have uncharacterized antiviral functions. We further defined ISGs that affect critical life-cycle processes in expression of VSV protein and MHV-68 immediate-early genes. Two previously undescribed antiviral ISGs, TAP1 and BMP2, were further validated. TAP1-deficient...
language: eng
source:
identifier: E-ISSN: 1091-6490 ; PMID: 22371602 Version:1 ; DOI: 10.1073/pnas.1114981109
fulltext: fulltext
issn:
  • 10916490
  • 1091-6490
url: Link


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titleSystematic identification of type I and type II interferon-induced antiviral factors
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subjectDNA Viruses -- Immunology ; Interferon Type I -- Immunology ; Interferon-Gamma -- Immunology ; Vesiculovirus -- Immunology
descriptionType I and type II interferons (IFNs) are cytokines that establish the cellular antiviral state through the induction of IFN-stimulated genes (ISGs). We sought to understand the basis of the antiviral activity induced by type I and II IFNs in relation to the functions of their ISGs. Based on gene expression studies, we systematically identified antiviral ISGs by performing blinded, functional screens on 288 type I and type II ISGs. We assessed and validated the antiviral activity of these ISGs against an RNA virus, vesicular stomatitis virus (VSV), and a DNA virus, murine gammaherpes virus (MHV-68). Overall, we identified 34 ISGs that elicited an antiviral effect on the replication of either one or both viruses. Fourteen ISGs have uncharacterized antiviral functions. We further defined ISGs that affect critical life-cycle processes in expression of VSV protein and MHV-68 immediate-early genes. Two previously undescribed antiviral ISGs, TAP1 and BMP2, were further validated. TAP1-deficient...
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descriptionType I and type II interferons (IFNs) are cytokines that establish the cellular antiviral state through the induction of IFN-stimulated genes (ISGs). We sought to understand the basis of the antiviral activity induced by type I and II IFNs in relation to the functions of their ISGs. Based on gene expression studies, we systematically identified antiviral ISGs by performing blinded, functional screens on 288 type I and type II ISGs. We assessed and validated the antiviral activity of these ISGs against an RNA virus, vesicular stomatitis virus (VSV), and a DNA virus, murine gammaherpes virus (MHV-68). Overall, we identified 34 ISGs that elicited an antiviral effect on the replication of either one or both viruses. Fourteen ISGs have uncharacterized antiviral functions. We further defined ISGs that affect critical life-cycle processes in expression of VSV protein and MHV-68 immediate-early genes. Two previously undescribed antiviral ISGs, TAP1 and BMP2, were further validated. TAP1-deficient...
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abstractType I and type II interferons (IFNs) are cytokines that establish the cellular antiviral state through the induction of IFN-stimulated genes (ISGs). We sought to understand the basis of the antiviral activity induced by type I and II IFNs in relation to the functions of their ISGs. Based on gene expression studies, we systematically identified antiviral ISGs by performing blinded, functional screens on 288 type I and type II ISGs. We assessed and validated the antiviral activity of these ISGs against an RNA virus, vesicular stomatitis virus (VSV), and a DNA virus, murine gammaherpes virus (MHV-68). Overall, we identified 34 ISGs that elicited an antiviral effect on the replication of either one or both viruses. Fourteen ISGs have uncharacterized antiviral functions. We further defined ISGs that affect critical life-cycle processes in expression of VSV protein and MHV-68 immediate-early genes. Two previously undescribed antiviral ISGs, TAP1 and BMP2, were further validated. TAP1-deficient...
doi10.1073/pnas.1114981109
pmid22371602
date2012-03-13