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Krüppel-like factor 9 is a circadian transcription factor in human epidermis that controls proliferation of keratinocytes

Circadian clocks govern a wide range of cellular and physiological functions in various organisms. Recent evidence suggests distinct functions of local clocks in peripheral mammalian tissues such as immune responses and cell cycle control. However, studying circadian action in peripheral tissues has... Full description

Journal Title: Proceedings of the National Academy of Sciences of the United States of America 03 July 2012, Vol.109(27), pp.10903-8
Main Author: Spörl, Florian
Other Authors: Korge, Sandra , Jürchott, Karsten , Wunderskirchner, Minetta , Schellenberg, Katja , Heins, Sven , Specht, Aljona , Stoll, Claudia , Klemz, Roman , Maier, Bert , Wenck, Horst , Schrader, Annika , Kunz, Dieter , Blatt, Thomas , Kramer, Achim
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1091-6490 ; PMID: 22711835 Version:1 ; DOI: 10.1073/pnas.1118641109
Link: http://pubmed.gov/22711835
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recordid: medline22711835
title: Krüppel-like factor 9 is a circadian transcription factor in human epidermis that controls proliferation of keratinocytes
format: Article
creator:
  • Spörl, Florian
  • Korge, Sandra
  • Jürchott, Karsten
  • Wunderskirchner, Minetta
  • Schellenberg, Katja
  • Heins, Sven
  • Specht, Aljona
  • Stoll, Claudia
  • Klemz, Roman
  • Maier, Bert
  • Wenck, Horst
  • Schrader, Annika
  • Kunz, Dieter
  • Blatt, Thomas
  • Kramer, Achim
subjects:
  • Circadian Rhythm -- Physiology
  • Epidermis -- Physiology
  • Keratinocytes -- Physiology
  • Kruppel-Like Transcription Factors -- Genetics
ispartof: Proceedings of the National Academy of Sciences of the United States of America, 03 July 2012, Vol.109(27), pp.10903-8
description: Circadian clocks govern a wide range of cellular and physiological functions in various organisms. Recent evidence suggests distinct functions of local clocks in peripheral mammalian tissues such as immune responses and cell cycle control. However, studying circadian action in peripheral tissues has been limited so far to mouse models, leaving the implication for human systems widely elusive. In particular, circadian rhythms in human skin, which is naturally exposed to strong daytime-dependent changes in the environment, have not been investigated to date on a molecular level. Here, we present a comprehensive analysis of circadian gene expression in human epidermis. Whole-genome microarray analysis of suction-blister epidermis obtained throughout the day revealed a functional circadian clock in epidermal keratinocytes with hundreds of transcripts regulated in a daytime-dependent manner. Among those, we identified a circadian transcription factor, Krüppel-like factor 9 (Klf9), that is substantially...
language: eng
source:
identifier: E-ISSN: 1091-6490 ; PMID: 22711835 Version:1 ; DOI: 10.1073/pnas.1118641109
fulltext: fulltext
issn:
  • 10916490
  • 1091-6490
url: Link


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titleKrüppel-like factor 9 is a circadian transcription factor in human epidermis that controls proliferation of keratinocytes
creatorSpörl, Florian ; Korge, Sandra ; Jürchott, Karsten ; Wunderskirchner, Minetta ; Schellenberg, Katja ; Heins, Sven ; Specht, Aljona ; Stoll, Claudia ; Klemz, Roman ; Maier, Bert ; Wenck, Horst ; Schrader, Annika ; Kunz, Dieter ; Blatt, Thomas ; Kramer, Achim
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subjectCircadian Rhythm -- Physiology ; Epidermis -- Physiology ; Keratinocytes -- Physiology ; Kruppel-Like Transcription Factors -- Genetics
descriptionCircadian clocks govern a wide range of cellular and physiological functions in various organisms. Recent evidence suggests distinct functions of local clocks in peripheral mammalian tissues such as immune responses and cell cycle control. However, studying circadian action in peripheral tissues has been limited so far to mouse models, leaving the implication for human systems widely elusive. In particular, circadian rhythms in human skin, which is naturally exposed to strong daytime-dependent changes in the environment, have not been investigated to date on a molecular level. Here, we present a comprehensive analysis of circadian gene expression in human epidermis. Whole-genome microarray analysis of suction-blister epidermis obtained throughout the day revealed a functional circadian clock in epidermal keratinocytes with hundreds of transcripts regulated in a daytime-dependent manner. Among those, we identified a circadian transcription factor, Krüppel-like factor 9 (Klf9), that is substantially...
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titleKrüppel-like factor 9 is a circadian transcription factor in human epidermis that controls proliferation of keratinocytes
descriptionCircadian clocks govern a wide range of cellular and physiological functions in various organisms. Recent evidence suggests distinct functions of local clocks in peripheral mammalian tissues such as immune responses and cell cycle control. However, studying circadian action in peripheral tissues has been limited so far to mouse models, leaving the implication for human systems widely elusive. In particular, circadian rhythms in human skin, which is naturally exposed to strong daytime-dependent changes in the environment, have not been investigated to date on a molecular level. Here, we present a comprehensive analysis of circadian gene expression in human epidermis. Whole-genome microarray analysis of suction-blister epidermis obtained throughout the day revealed a functional circadian clock in epidermal keratinocytes with hundreds of transcripts regulated in a daytime-dependent manner. Among those, we identified a circadian transcription factor, Krüppel-like factor 9 (Klf9), that is substantially...
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authorSpörl, Florian ; Korge, Sandra ; Jürchott, Karsten ; Wunderskirchner, Minetta ; Schellenberg, Katja ; Heins, Sven ; Specht, Aljona ; Stoll, Claudia ; Klemz, Roman ; Maier, Bert ; Wenck, Horst ; Schrader, Annika ; Kunz, Dieter ; Blatt, Thomas ; Kramer, Achim
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abstractCircadian clocks govern a wide range of cellular and physiological functions in various organisms. Recent evidence suggests distinct functions of local clocks in peripheral mammalian tissues such as immune responses and cell cycle control. However, studying circadian action in peripheral tissues has been limited so far to mouse models, leaving the implication for human systems widely elusive. In particular, circadian rhythms in human skin, which is naturally exposed to strong daytime-dependent changes in the environment, have not been investigated to date on a molecular level. Here, we present a comprehensive analysis of circadian gene expression in human epidermis. Whole-genome microarray analysis of suction-blister epidermis obtained throughout the day revealed a functional circadian clock in epidermal keratinocytes with hundreds of transcripts regulated in a daytime-dependent manner. Among those, we identified a circadian transcription factor, Krüppel-like factor 9 (Klf9), that is substantially...
doi10.1073/pnas.1118641109
pmid22711835
date2012-07-03