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PES1 promotes breast cancer by differentially regulating ERα and ERβ

The initiation of breast cancer is associated with increased expression of tumor-promoting estrogen receptor α (ERα) protein and decreased expression of tumor-suppressive ERβ protein. However, the mechanism underlying this process is unknown. Here we show that PES1 (also known as Pescadillo), an est... Full description

Journal Title: The Journal of clinical investigation August 2012, Vol.122(8), pp.2857-70
Main Author: Cheng, Long
Other Authors: Li, Jieping , Han, Yongjian , Lin, Jing , Niu, Chang , Zhou, Zhichao , Yuan, Bin , Huang, Ke , Li, Jiezhi , Jiang, Kai , Zhang, Hao , Ding, Lihua , Xu, Xiaojie , Ye, Qinong
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1558-8238 ; PMID: 22820289 Version:1 ; DOI: 10.1172/JCI62676
Link: http://pubmed.gov/22820289
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recordid: medline22820289
title: PES1 promotes breast cancer by differentially regulating ERα and ERβ
format: Article
creator:
  • Cheng, Long
  • Li, Jieping
  • Han, Yongjian
  • Lin, Jing
  • Niu, Chang
  • Zhou, Zhichao
  • Yuan, Bin
  • Huang, Ke
  • Li, Jiezhi
  • Jiang, Kai
  • Zhang, Hao
  • Ding, Lihua
  • Xu, Xiaojie
  • Ye, Qinong
subjects:
  • Breast Neoplasms -- Etiology
  • Estrogen Receptor Alpha -- Metabolism
  • Estrogen Receptor Beta -- Metabolism
  • Proteins -- Metabolism
ispartof: The Journal of clinical investigation, August 2012, Vol.122(8), pp.2857-70
description: The initiation of breast cancer is associated with increased expression of tumor-promoting estrogen receptor α (ERα) protein and decreased expression of tumor-suppressive ERβ protein. However, the mechanism underlying this process is unknown. Here we show that PES1 (also known as Pescadillo), an estrogen-inducible protein that is overexpressed in breast cancer, can regulate the balance between ERα and ERβ. We found that PES1 modulated many estrogen-responsive genes by enhancing the transcriptional activity of ERα while inhibiting transcriptional activity of ERβ. Consistent with this regulation of ERα and ERβ transcriptional activity, PES1 increased the stability of the ERα protein and decreased that of ERβ through the ubiquitin-proteasome pathway, mediated by the carboxyl terminus of Hsc70-interacting protein (CHIP). Moreover, PES1 transformed normal human mammary epithelial cells and was required for estrogen-induced breast tumor growth in nude mice. Further analysis of clinical samples...
language: eng
source:
identifier: E-ISSN: 1558-8238 ; PMID: 22820289 Version:1 ; DOI: 10.1172/JCI62676
fulltext: fulltext
issn:
  • 15588238
  • 1558-8238
url: Link


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titlePES1 promotes breast cancer by differentially regulating ERα and ERβ
creatorCheng, Long ; Li, Jieping ; Han, Yongjian ; Lin, Jing ; Niu, Chang ; Zhou, Zhichao ; Yuan, Bin ; Huang, Ke ; Li, Jiezhi ; Jiang, Kai ; Zhang, Hao ; Ding, Lihua ; Xu, Xiaojie ; Ye, Qinong
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subjectBreast Neoplasms -- Etiology ; Estrogen Receptor Alpha -- Metabolism ; Estrogen Receptor Beta -- Metabolism ; Proteins -- Metabolism
descriptionThe initiation of breast cancer is associated with increased expression of tumor-promoting estrogen receptor α (ERα) protein and decreased expression of tumor-suppressive ERβ protein. However, the mechanism underlying this process is unknown. Here we show that PES1 (also known as Pescadillo), an estrogen-inducible protein that is overexpressed in breast cancer, can regulate the balance between ERα and ERβ. We found that PES1 modulated many estrogen-responsive genes by enhancing the transcriptional activity of ERα while inhibiting transcriptional activity of ERβ. Consistent with this regulation of ERα and ERβ transcriptional activity, PES1 increased the stability of the ERα protein and decreased that of ERβ through the ubiquitin-proteasome pathway, mediated by the carboxyl terminus of Hsc70-interacting protein (CHIP). Moreover, PES1 transformed normal human mammary epithelial cells and was required for estrogen-induced breast tumor growth in nude mice. Further analysis of clinical samples...
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descriptionThe initiation of breast cancer is associated with increased expression of tumor-promoting estrogen receptor α (ERα) protein and decreased expression of tumor-suppressive ERβ protein. However, the mechanism underlying this process is unknown. Here we show that PES1 (also known as Pescadillo), an estrogen-inducible protein that is overexpressed in breast cancer, can regulate the balance between ERα and ERβ. We found that PES1 modulated many estrogen-responsive genes by enhancing the transcriptional activity of ERα while inhibiting transcriptional activity of ERβ. Consistent with this regulation of ERα and ERβ transcriptional activity, PES1 increased the stability of the ERα protein and decreased that of ERβ through the ubiquitin-proteasome pathway, mediated by the carboxyl terminus of Hsc70-interacting protein (CHIP). Moreover, PES1 transformed normal human mammary epithelial cells and was required for estrogen-induced breast tumor growth in nude mice. Further analysis of clinical samples...
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abstractThe initiation of breast cancer is associated with increased expression of tumor-promoting estrogen receptor α (ERα) protein and decreased expression of tumor-suppressive ERβ protein. However, the mechanism underlying this process is unknown. Here we show that PES1 (also known as Pescadillo), an estrogen-inducible protein that is overexpressed in breast cancer, can regulate the balance between ERα and ERβ. We found that PES1 modulated many estrogen-responsive genes by enhancing the transcriptional activity of ERα while inhibiting transcriptional activity of ERβ. Consistent with this regulation of ERα and ERβ transcriptional activity, PES1 increased the stability of the ERα protein and decreased that of ERβ through the ubiquitin-proteasome pathway, mediated by the carboxyl terminus of Hsc70-interacting protein (CHIP). Moreover, PES1 transformed normal human mammary epithelial cells and was required for estrogen-induced breast tumor growth in nude mice. Further analysis of clinical samples...
doi10.1172/JCI62676
pmid22820289
date2012-08-01