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STAT3 negatively regulates thyroid tumorigenesis

Although tyrosine-phosphorylated or activated STAT3 (pY-STAT3) is a well-described mediator of tumorigenesis, its role in thyroid cancer has not been investigated. We observed that 63 of 110 (57%) human primary papillary thyroid carcinoma (PTC) cases expressed nuclear pY-STAT3 in tumor cells, prefer... Full description

Journal Title: Proceedings of the National Academy of Sciences of the United States of America 28 August 2012, Vol.109(35), pp.E2361-70
Main Author: Couto, Joana Pinto
Other Authors: Daly, Laura , Almeida, Ana , Knauf, Jeffrey A , Fagin, James A , Sobrinho-Simões, Manuel , Lima, Jorge , Máximo, Valdemar , Soares, Paula , Lyden, David , Bromberg, Jacqueline F
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1091-6490 ; PMID: 22891351 Version:1 ; DOI: 10.1073/pnas.1201232109
Link: http://pubmed.gov/22891351
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recordid: medline22891351
title: STAT3 negatively regulates thyroid tumorigenesis
format: Article
creator:
  • Couto, Joana Pinto
  • Daly, Laura
  • Almeida, Ana
  • Knauf, Jeffrey A
  • Fagin, James A
  • Sobrinho-Simões, Manuel
  • Lima, Jorge
  • Máximo, Valdemar
  • Soares, Paula
  • Lyden, David
  • Bromberg, Jacqueline F
subjects:
  • Carcinoma, Papillary -- Metabolism
  • Stat3 Transcription Factor -- Metabolism
  • Signal Transduction -- Physiology
  • Thyroid Neoplasms -- Metabolism
ispartof: Proceedings of the National Academy of Sciences of the United States of America, 28 August 2012, Vol.109(35), pp.E2361-70
description: Although tyrosine-phosphorylated or activated STAT3 (pY-STAT3) is a well-described mediator of tumorigenesis, its role in thyroid cancer has not been investigated. We observed that 63 of 110 (57%) human primary papillary thyroid carcinoma (PTC) cases expressed nuclear pY-STAT3 in tumor cells, preferentially in association with the tumor stroma. An inverse relationship between pY-STAT3 expression with tumor size and the presence of distant metastases was observed. Using human thyroid cancer-derived cell lines [harboring rearranged during transfection (RET)/PTC, v-RAF murine sarcoma viral oncogene homolog B (BRAF), or rat sarcoma virus oncogene (RAS) alterations], we determined that IL-6/gp130/JAK signaling is responsible for STAT3 activation. STAT3 knockdown by shRNA in representative thyroid cancer cell lines that express high levels of pY-STAT3 had no effect on in vitro growth. However, xenografted short hairpin STAT3 cells generated larger tumors than control cells. Similarly, STAT3 deficiency...
language: eng
source:
identifier: E-ISSN: 1091-6490 ; PMID: 22891351 Version:1 ; DOI: 10.1073/pnas.1201232109
fulltext: fulltext
issn:
  • 10916490
  • 1091-6490
url: Link


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titleSTAT3 negatively regulates thyroid tumorigenesis
creatorCouto, Joana Pinto ; Daly, Laura ; Almeida, Ana ; Knauf, Jeffrey A ; Fagin, James A ; Sobrinho-Simões, Manuel ; Lima, Jorge ; Máximo, Valdemar ; Soares, Paula ; Lyden, David ; Bromberg, Jacqueline F
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descriptionAlthough tyrosine-phosphorylated or activated STAT3 (pY-STAT3) is a well-described mediator of tumorigenesis, its role in thyroid cancer has not been investigated. We observed that 63 of 110 (57%) human primary papillary thyroid carcinoma (PTC) cases expressed nuclear pY-STAT3 in tumor cells, preferentially in association with the tumor stroma. An inverse relationship between pY-STAT3 expression with tumor size and the presence of distant metastases was observed. Using human thyroid cancer-derived cell lines [harboring rearranged during transfection (RET)/PTC, v-RAF murine sarcoma viral oncogene homolog B (BRAF), or rat sarcoma virus oncogene (RAS) alterations], we determined that IL-6/gp130/JAK signaling is responsible for STAT3 activation. STAT3 knockdown by shRNA in representative thyroid cancer cell lines that express high levels of pY-STAT3 had no effect on in vitro growth. However, xenografted short hairpin STAT3 cells generated larger tumors than control cells. Similarly, STAT3 deficiency...
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descriptionAlthough tyrosine-phosphorylated or activated STAT3 (pY-STAT3) is a well-described mediator of tumorigenesis, its role in thyroid cancer has not been investigated. We observed that 63 of 110 (57%) human primary papillary thyroid carcinoma (PTC) cases expressed nuclear pY-STAT3 in tumor cells, preferentially in association with the tumor stroma. An inverse relationship between pY-STAT3 expression with tumor size and the presence of distant metastases was observed. Using human thyroid cancer-derived cell lines [harboring rearranged during transfection (RET)/PTC, v-RAF murine sarcoma viral oncogene homolog B (BRAF), or rat sarcoma virus oncogene (RAS) alterations], we determined that IL-6/gp130/JAK signaling is responsible for STAT3 activation. STAT3 knockdown by shRNA in representative thyroid cancer cell lines that express high levels of pY-STAT3 had no effect on in vitro growth. However, xenografted short hairpin STAT3 cells generated larger tumors than control cells. Similarly, STAT3 deficiency...
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abstractAlthough tyrosine-phosphorylated or activated STAT3 (pY-STAT3) is a well-described mediator of tumorigenesis, its role in thyroid cancer has not been investigated. We observed that 63 of 110 (57%) human primary papillary thyroid carcinoma (PTC) cases expressed nuclear pY-STAT3 in tumor cells, preferentially in association with the tumor stroma. An inverse relationship between pY-STAT3 expression with tumor size and the presence of distant metastases was observed. Using human thyroid cancer-derived cell lines [harboring rearranged during transfection (RET)/PTC, v-RAF murine sarcoma viral oncogene homolog B (BRAF), or rat sarcoma virus oncogene (RAS) alterations], we determined that IL-6/gp130/JAK signaling is responsible for STAT3 activation. STAT3 knockdown by shRNA in representative thyroid cancer cell lines that express high levels of pY-STAT3 had no effect on in vitro growth. However, xenografted short hairpin STAT3 cells generated larger tumors than control cells. Similarly, STAT3 deficiency...
doi10.1073/pnas.1201232109
pmid22891351
date2012-08-28