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Short-term hyperthermia promotes the sensitivity of MCF-7 human breast cancer cells to paclitaxel

As a physical adjuvant approach in the treatment of solid tumors, regional hyperthermia plays a synergistic role in enhancing the efficacy of simultaneous chemotherapy. Paclitaxel (PTX) is an anti-mitotic taxane drug that is widely used in chemotherapy for the treatment of various human malignancies... Full description

Journal Title: Biological & pharmaceutical bulletin 2013, Vol.36(3), pp.376-83
Main Author: Lin, Yan
Other Authors: Liu, Zhihui , Li, Yongqiang , Liao, Xiaoli , Liao, Sina , Cen, Shaofang , Yang, Ling , Wei, Jiazhang , Hu, Xiaohua
Format: Electronic Article Electronic Article
Language: English
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ID: E-ISSN: 1347-5215 ; PMID: 23229357 Version:1
Link: http://pubmed.gov/23229357
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recordid: medline23229357
title: Short-term hyperthermia promotes the sensitivity of MCF-7 human breast cancer cells to paclitaxel
format: Article
creator:
  • Lin, Yan
  • Liu, Zhihui
  • Li, Yongqiang
  • Liao, Xiaoli
  • Liao, Sina
  • Cen, Shaofang
  • Yang, Ling
  • Wei, Jiazhang
  • Hu, Xiaohua
subjects:
  • Hyperthermia, Induced
  • Antineoplastic Agents, Phytogenic -- Pharmacology
  • Breast Neoplasms -- Therapy
  • Paclitaxel -- Pharmacology
ispartof: Biological & pharmaceutical bulletin, 2013, Vol.36(3), pp.376-83
description: As a physical adjuvant approach in the treatment of solid tumors, regional hyperthermia plays a synergistic role in enhancing the efficacy of simultaneous chemotherapy. Paclitaxel (PTX) is an anti-mitotic taxane drug that is widely used in chemotherapy for the treatment of various human malignancies such as lung, ovarian, breast, and head and neck cancers. Since the possibility that hyperthermia can enhance the anti-tumor effects of PTX has not yet been investigated, the present study was designed to evaluate the effects of short-term hyperthermia on PTX-induced antitumor activity in the human breast cancer line MCF-7. It was found that short-term hyperthermia promoted PTX-induced suppression of cell proliferation. The IC for PTX was reduced from 18.2±1.0 to 15.0±0.45 nM (p
language: eng
source:
identifier: E-ISSN: 1347-5215 ; PMID: 23229357 Version:1
fulltext: fulltext
issn:
  • 13475215
  • 1347-5215
url: Link


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titleShort-term hyperthermia promotes the sensitivity of MCF-7 human breast cancer cells to paclitaxel
creatorLin, Yan ; Liu, Zhihui ; Li, Yongqiang ; Liao, Xiaoli ; Liao, Sina ; Cen, Shaofang ; Yang, Ling ; Wei, Jiazhang ; Hu, Xiaohua
ispartofBiological & pharmaceutical bulletin, 2013, Vol.36(3), pp.376-83
identifierE-ISSN: 1347-5215 ; PMID: 23229357 Version:1
subjectHyperthermia, Induced ; Antineoplastic Agents, Phytogenic -- Pharmacology ; Breast Neoplasms -- Therapy ; Paclitaxel -- Pharmacology
descriptionAs a physical adjuvant approach in the treatment of solid tumors, regional hyperthermia plays a synergistic role in enhancing the efficacy of simultaneous chemotherapy. Paclitaxel (PTX) is an anti-mitotic taxane drug that is widely used in chemotherapy for the treatment of various human malignancies such as lung, ovarian, breast, and head and neck cancers. Since the possibility that hyperthermia can enhance the anti-tumor effects of PTX has not yet been investigated, the present study was designed to evaluate the effects of short-term hyperthermia on PTX-induced antitumor activity in the human breast cancer line MCF-7. It was found that short-term hyperthermia promoted PTX-induced suppression of cell proliferation. The IC for PTX was reduced from 18.2±1.0 to 15.0±0.45 nM (p<0.05). The level of PTX-induced cell apoptosis was increased from 8.5±1.2 to 16.4±2.4% (p<0.05) and from 15.2±1.4 to 34.9±2.8% (p<0.05), at the end of the first and second hyperthermia cycles, respectively; both the...
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titleShort-term hyperthermia promotes the sensitivity of MCF-7 human breast cancer cells to paclitaxel
descriptionAs a physical adjuvant approach in the treatment of solid tumors, regional hyperthermia plays a synergistic role in enhancing the efficacy of simultaneous chemotherapy. Paclitaxel (PTX) is an anti-mitotic taxane drug that is widely used in chemotherapy for the treatment of various human malignancies such as lung, ovarian, breast, and head and neck cancers. Since the possibility that hyperthermia can enhance the anti-tumor effects of PTX has not yet been investigated, the present study was designed to evaluate the effects of short-term hyperthermia on PTX-induced antitumor activity in the human breast cancer line MCF-7. It was found that short-term hyperthermia promoted PTX-induced suppression of cell proliferation. The IC for PTX was reduced from 18.2±1.0 to 15.0±0.45 nM (p<0.05). The level of PTX-induced cell apoptosis was increased from 8.5±1.2 to 16.4±2.4% (p<0.05) and from 15.2±1.4 to 34.9±2.8% (p<0.05), at the end of the first and second hyperthermia cycles, respectively; both the...
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abstractAs a physical adjuvant approach in the treatment of solid tumors, regional hyperthermia plays a synergistic role in enhancing the efficacy of simultaneous chemotherapy. Paclitaxel (PTX) is an anti-mitotic taxane drug that is widely used in chemotherapy for the treatment of various human malignancies such as lung, ovarian, breast, and head and neck cancers. Since the possibility that hyperthermia can enhance the anti-tumor effects of PTX has not yet been investigated, the present study was designed to evaluate the effects of short-term hyperthermia on PTX-induced antitumor activity in the human breast cancer line MCF-7. It was found that short-term hyperthermia promoted PTX-induced suppression of cell proliferation. The IC for PTX was reduced from 18.2±1.0 to 15.0±0.45 nM (p<0.05). The level of PTX-induced cell apoptosis was increased from 8.5±1.2 to 16.4±2.4% (p<0.05) and from 15.2±1.4 to 34.9±2.8% (p<0.05), at the end of the first and second hyperthermia cycles, respectively; both the...
pmid23229357
doi10.1248/bpb.b12-00774