schliessen

Filtern

 

Bibliotheken

Corticosteroid-induced neural remodeling predicts behavioral vulnerability and resilience

Neurons in distinct brain regions remodel in response to postnatal stressor exposure, and structural plasticity may underlie stress-related modifications in behavioral outcomes. Given the persistence of stress-related diseases such as depression, a critical next step in identifying the contributions... Full description

Journal Title: The Journal of neuroscience : the official journal of the Society for Neuroscience 13 February 2013, Vol.33(7), pp.3107-12
Main Author: Gourley, Shannon L
Other Authors: Swanson, Andrew M , Koleske, Anthony J
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1529-2401 ; PMID: 23407965 Version:1 ; DOI: 10.1523/JNEUROSCI.2138-12.2013
Link: http://pubmed.gov/23407965
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: medline23407965
title: Corticosteroid-induced neural remodeling predicts behavioral vulnerability and resilience
format: Article
creator:
  • Gourley, Shannon L
  • Swanson, Andrew M
  • Koleske, Anthony J
subjects:
  • Behavior, Animal -- Drug Effects
  • Corticosterone -- Pharmacology
  • Neurons -- Drug Effects
  • Resilience, Psychological -- Drug Effects
ispartof: The Journal of neuroscience : the official journal of the Society for Neuroscience, 13 February 2013, Vol.33(7), pp.3107-12
description: Neurons in distinct brain regions remodel in response to postnatal stressor exposure, and structural plasticity may underlie stress-related modifications in behavioral outcomes. Given the persistence of stress-related diseases such as depression, a critical next step in identifying the contributions of neural structure to psychopathology will be to identify brain circuits and cell types that fail to recover from stressor exposure. We enumerated dendritic spines during and after chronic stress hormone exposure in hippocampal CA1, deep-layer prefrontal cortex, and the basal amygdala and also reconstructed dendritic arbors of CA1 pyramidal neurons. Corticosterone modified dendritic spine density in these regions, but with the exception of the orbitofrontal cortex, densities normalized with a recovery period. Dendritic retraction of hippocampal CA1 neurons and anhedonic-like insensitivity to a sucrose solution also persisted despite a recovery period. Using mice with reduced gene dosage of...
language: eng
source:
identifier: E-ISSN: 1529-2401 ; PMID: 23407965 Version:1 ; DOI: 10.1523/JNEUROSCI.2138-12.2013
fulltext: fulltext
issn:
  • 15292401
  • 1529-2401
url: Link


@attributes
ID528008161
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordid23407965
sourceidmedline
recordidTN_medline23407965
sourceformatXML
sourcesystemPC
pqid1288316107
display
typearticle
titleCorticosteroid-induced neural remodeling predicts behavioral vulnerability and resilience
creatorGourley, Shannon L ; Swanson, Andrew M ; Koleske, Anthony J
ispartofThe Journal of neuroscience : the official journal of the Society for Neuroscience, 13 February 2013, Vol.33(7), pp.3107-12
identifier
subjectBehavior, Animal -- Drug Effects ; Corticosterone -- Pharmacology ; Neurons -- Drug Effects ; Resilience, Psychological -- Drug Effects
descriptionNeurons in distinct brain regions remodel in response to postnatal stressor exposure, and structural plasticity may underlie stress-related modifications in behavioral outcomes. Given the persistence of stress-related diseases such as depression, a critical next step in identifying the contributions of neural structure to psychopathology will be to identify brain circuits and cell types that fail to recover from stressor exposure. We enumerated dendritic spines during and after chronic stress hormone exposure in hippocampal CA1, deep-layer prefrontal cortex, and the basal amygdala and also reconstructed dendritic arbors of CA1 pyramidal neurons. Corticosterone modified dendritic spine density in these regions, but with the exception of the orbitofrontal cortex, densities normalized with a recovery period. Dendritic retraction of hippocampal CA1 neurons and anhedonic-like insensitivity to a sucrose solution also persisted despite a recovery period. Using mice with reduced gene dosage of...
languageeng
source
version4
lds50peer_reviewed
links
openurl$$Topenurl_article
backlink$$Uhttp://pubmed.gov/23407965$$EView_this_record_in_MEDLINE/PubMed
openurlfulltext$$Topenurlfull_article
addlink$$Uhttp://exlibris-pub.s3.amazonaws.com/aboutMedline.html$$EView_the_MEDLINE/PubMed_Copyright_Statement
search
creatorcontrib
0Gourley, Shannon L
1Swanson, Andrew M
2Koleske, Anthony J
titleCorticosteroid-induced neural remodeling predicts behavioral vulnerability and resilience
descriptionNeurons in distinct brain regions remodel in response to postnatal stressor exposure, and structural plasticity may underlie stress-related modifications in behavioral outcomes. Given the persistence of stress-related diseases such as depression, a critical next step in identifying the contributions of neural structure to psychopathology will be to identify brain circuits and cell types that fail to recover from stressor exposure. We enumerated dendritic spines during and after chronic stress hormone exposure in hippocampal CA1, deep-layer prefrontal cortex, and the basal amygdala and also reconstructed dendritic arbors of CA1 pyramidal neurons. Corticosterone modified dendritic spine density in these regions, but with the exception of the orbitofrontal cortex, densities normalized with a recovery period. Dendritic retraction of hippocampal CA1 neurons and anhedonic-like insensitivity to a sucrose solution also persisted despite a recovery period. Using mice with reduced gene dosage of...
subject
0Behavior, Animal -- Drug Effects
1Corticosterone -- Pharmacology
2Neurons -- Drug Effects
3Resilience, Psychological -- Drug Effects
general
023407965
1English
2MEDLINE/PubMed (U.S. National Library of Medicine)
310.1523/JNEUROSCI.2138-12.2013
4MEDLINE/PubMed (NLM)
sourceidmedline
recordidmedline23407965
issn
015292401
11529-2401
rsrctypearticle
creationdate2013
addtitleThe Journal of neuroscience : the official journal of the Society for Neuroscience
searchscope
0medline
1nlm_medline
2MEDLINE
scope
0medline
1nlm_medline
2MEDLINE
lsr4120130213
citationpf 3107 vol 33 issue 7
startdate20130213
enddate20130213
lsr30VSR-Enriched:[pqid, pages]
sort
titleCorticosteroid-induced neural remodeling predicts behavioral vulnerability and resilience
authorGourley, Shannon L ; Swanson, Andrew M ; Koleske, Anthony J
creationdate20130213
lso0120130213
facets
frbrgroupid6040276068817572967
frbrtype5
newrecords20190701
languageeng
creationdate2013
topic
0Behavior, Animal–Drug Effects
1Corticosterone–Pharmacology
2Neurons–Drug Effects
3Resilience, Psychological–Drug Effects
collectionMEDLINE/PubMed (NLM)
prefilterarticles
rsrctypearticles
creatorcontrib
0Gourley, Shannon L
1Swanson, Andrew M
2Koleske, Anthony J
jtitleJournal Of Neuroscience : The Official Journal Of The Society For Neuroscience
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
aulast
0Gourley
1Swanson
2Koleske
aufirst
0Shannon L
1Andrew M
2Anthony J
au
0Gourley, Shannon L
1Swanson, Andrew M
2Koleske, Anthony J
atitleCorticosteroid-induced neural remodeling predicts behavioral vulnerability and resilience
jtitleThe Journal of neuroscience : the official journal of the Society for Neuroscience
risdate20130213
volume33
issue7
spage3107
pages3107-3112
issn0270-6474
eissn1529-2401
formatjournal
genrearticle
ristypeJOUR
abstractNeurons in distinct brain regions remodel in response to postnatal stressor exposure, and structural plasticity may underlie stress-related modifications in behavioral outcomes. Given the persistence of stress-related diseases such as depression, a critical next step in identifying the contributions of neural structure to psychopathology will be to identify brain circuits and cell types that fail to recover from stressor exposure. We enumerated dendritic spines during and after chronic stress hormone exposure in hippocampal CA1, deep-layer prefrontal cortex, and the basal amygdala and also reconstructed dendritic arbors of CA1 pyramidal neurons. Corticosterone modified dendritic spine density in these regions, but with the exception of the orbitofrontal cortex, densities normalized with a recovery period. Dendritic retraction of hippocampal CA1 neurons and anhedonic-like insensitivity to a sucrose solution also persisted despite a recovery period. Using mice with reduced gene dosage of...
doi10.1523/JNEUROSCI.2138-12.2013
pmid23407965
date2013-02-13