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HIV-1 Nef: hacker of the host cell

HIV-1 is a deadly virus that causes AIDS and is responsible for devastating lives globally over the last three decades [1]. HIV-1 has three structural genes (gag, pol and env), two regulatory genes (tat and rev) and four accessory genes (vif, vpu, vpr and nef ). These work together to invade and deg... Full description

Journal Title: Future virology 01 February 2012, Vol.7(2), pp.117-120
Main Author: Saxena, Shailendra K
Other Authors: Shrivastava, Gaurav , Tiwari, Sneham , Nair, Madhavan Pn
Format: Electronic Article Electronic Article
Language: English
Subjects:
Cd4
Nef
ID: ISSN: 1746-0794 ; PMID: 23847689 Version:1
Link: http://pubmed.gov/23847689
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title: HIV-1 Nef: hacker of the host cell
format: Article
creator:
  • Saxena, Shailendra K
  • Shrivastava, Gaurav
  • Tiwari, Sneham
  • Nair, Madhavan Pn
subjects:
  • Cd4
  • HIV-1
  • Mhc-I Downregulation
  • Nef
  • T-Cell Activation
  • Apoptosis
  • Host Cellular Proteins
  • P21-Activated Kinase 2
  • P53 Tumor Suppressing Protein
ispartof: Future virology, 01 February 2012, Vol.7(2), pp.117-120
description: HIV-1 is a deadly virus that causes AIDS and is responsible for devastating lives globally over the last three decades [1]. HIV-1 has three structural genes (gag, pol and env), two regulatory genes (tat and rev) and four accessory genes (vif, vpu, vpr and nef ). These work together to invade and degrade the host cell machinery, causing fatal disease. Of this group, one important gene is nef (which codes for the Nef protein), which has been an important focus for studies since 1988 (Figure 1). Initially, Nef was thought to play a negative role, possibly inhibiting viral replication, but later studies have shown it to be necessary for enhancing viral loadassociated infection, and inhibiting infected cell death. It has been shown that HIV-1 Nef plays a vital role in CD4 downregulation, MHC-I downregulation, CD28 downregulation and T‑cell activation, which eventually contribute to disease progression [2]. Studies are still being carried out to understand the fine mechanisms used by Nef to interact with various cellular proteins that result in host cell arrest, which make Nef so aggressive and make HIV an effective virus.
language: eng
source:
identifier: ISSN: 1746-0794 ; PMID: 23847689 Version:1
fulltext: fulltext
issn:
  • 17460794
  • 1746-0794
url: Link


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titleHIV-1 Nef: hacker of the host cell
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identifierISSN: 1746-0794 ; PMID: 23847689 Version:1
subjectCd4 ; HIV-1 ; Mhc-I Downregulation ; Nef ; T-Cell Activation ; Apoptosis ; Host Cellular Proteins ; P21-Activated Kinase 2 ; P53 Tumor Suppressing Protein
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descriptionHIV-1 is a deadly virus that causes AIDS and is responsible for devastating lives globally over the last three decades [1]. HIV-1 has three structural genes (gag, pol and env), two regulatory genes (tat and rev) and four accessory genes (vif, vpu, vpr and nef ). These work together to invade and degrade the host cell machinery, causing fatal disease. Of this group, one important gene is nef (which codes for the Nef protein), which has been an important focus for studies since 1988 (Figure 1). Initially, Nef was thought to play a negative role, possibly inhibiting viral replication, but later studies have shown it to be necessary for enhancing viral loadassociated infection, and inhibiting infected cell death. It has been shown that HIV-1 Nef plays a vital role in CD4 downregulation, MHC-I downregulation, CD28 downregulation and T‑cell activation, which eventually contribute to disease progression [2]. Studies are still being carried out to understand the fine mechanisms used by Nef to interact with various cellular proteins that result in host cell arrest, which make Nef so aggressive and make HIV an effective virus.
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