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Sustained broad-spectrum antibacterial effects of nanoliposomes loaded with silver nanoparticles

The emergence of microbial resistance to antibiotics warrants the search for effective broad-spectrum antibacterial agents. Silver nanoparticles (AgNPs) have been used as antimicrobial agents. AgNPs encapsulated in nanolipososmes have been developed as effective antimicrobial agents. Nanoliposomes (

Journal Title: Nanomedicine (London England), July 2014, Vol.9(9), pp.1301-10
Main Author: Eid, Kamel A M
Other Authors: Azzazy, Hassan M E
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1748-6963 ; PMID: 24024570 Version:1 ; DOI: 10.2217/nnm.13.89
Link: http://pubmed.gov/24024570
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recordid: medline24024570
title: Sustained broad-spectrum antibacterial effects of nanoliposomes loaded with silver nanoparticles
format: Article
creator:
  • Eid, Kamel A M
  • Azzazy, Hassan M E
subjects:
  • Antibacterial Effect
  • Broad Spectrum
  • Liposome
  • Silver Nanoparticle
  • Sustained Release
  • Anti-Bacterial Agents -- Pharmacology
  • Metal Nanoparticles -- Therapeutic Use
  • Silver -- Pharmacology
ispartof: Nanomedicine (London, England), July 2014, Vol.9(9), pp.1301-10
description: The emergence of microbial resistance to antibiotics warrants the search for effective broad-spectrum antibacterial agents. Silver nanoparticles (AgNPs) have been used as antimicrobial agents. AgNPs encapsulated in nanolipososmes have been developed as effective antimicrobial agents. Nanoliposomes (
language: eng
source:
identifier: E-ISSN: 1748-6963 ; PMID: 24024570 Version:1 ; DOI: 10.2217/nnm.13.89
fulltext: fulltext
issn:
  • 17486963
  • 1748-6963
url: Link


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titleSustained broad-spectrum antibacterial effects of nanoliposomes loaded with silver nanoparticles
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subjectAntibacterial Effect ; Broad Spectrum ; Liposome ; Silver Nanoparticle ; Sustained Release ; Anti-Bacterial Agents -- Pharmacology ; Metal Nanoparticles -- Therapeutic Use ; Silver -- Pharmacology
descriptionThe emergence of microbial resistance to antibiotics warrants the search for effective broad-spectrum antibacterial agents. Silver nanoparticles (AgNPs) have been used as antimicrobial agents. AgNPs encapsulated in nanolipososmes have been developed as effective antimicrobial agents. Nanoliposomes (<50 nm) were prepared using a modified reverse-phase evaporation method, and spherical, dextrose-capped AgNPs were synthesized. The prepared liposome AgNPs (LAgNPs) were characterized, and tested for their antibacterial effects. The size of LAgNPs is 25-80 nm. The release of AgNPs from nanoliposomes was sustained over 10 h. Complete growth inhibition of Eschericia coli, Salmonella enterica, Pseudomonas aeruginosa and Staphylococcus aureus was achieved using 180, 200, 160 and 120 µM, respectively, of LAgNPs. LAgNPs exhibited sustained broad-spectrum antibacterial effects compared with free AgNPs. Nanoliposomes loaded with AgNPs are potentially effective broad-spectrum antimicrobial agents. This new formula, which can be further fortified by encapsulation of additional established antibacterial agents, may be effective against antibiotic-resistant bacteria and also promote wound healing.
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0The emergence of microbial resistance to antibiotics warrants the search for effective broad-spectrum antibacterial agents. Silver nanoparticles (AgNPs) have been used as antimicrobial agents. AgNPs encapsulated in nanolipososmes have been developed as effective antimicrobial agents.
1Nanoliposomes (<50 nm) were prepared using a modified reverse-phase evaporation method, and spherical, dextrose-capped AgNPs were synthesized. The prepared liposome AgNPs (LAgNPs) were characterized, and tested for their antibacterial effects.
2The size of LAgNPs is 25-80 nm. The release of AgNPs from nanoliposomes was sustained over 10 h. Complete growth inhibition of Eschericia coli, Salmonella enterica, Pseudomonas aeruginosa and Staphylococcus aureus was achieved using 180, 200, 160 and 120 µM, respectively, of LAgNPs. LAgNPs exhibited sustained broad-spectrum antibacterial effects compared with free AgNPs.
3Nanoliposomes loaded with AgNPs are potentially effective broad-spectrum antimicrobial agents. This new formula, which can be further fortified by encapsulation of additional established antibacterial agents, may be effective against antibiotic-resistant bacteria and also promote wound healing.
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abstractThe emergence of microbial resistance to antibiotics warrants the search for effective broad-spectrum antibacterial agents. Silver nanoparticles (AgNPs) have been used as antimicrobial agents. AgNPs encapsulated in nanolipososmes have been developed as effective antimicrobial agents.
doi10.2217/nnm.13.89
pmid24024570
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date2014-07-01