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Suppression of WC-independent frequency transcription by RCO-1 is essential for Neurospora circadian clock

Rhythmic activation and repression of clock gene transcription is essential for the functions of eukaryotic circadian clocks. In the Neurospora circadian oscillator, frequency (frq) transcription requires the WHITE COLLAR (WC) complex. Here, we show that the transcriptional corepressor regulation of... Full description

Journal Title: Proceedings of the National Academy of Sciences of the United States of America 10 December 2013, Vol.110(50), pp.E4867-74
Main Author: Zhou, Zhipeng
Other Authors: Liu, Xiao , Hu, Qiwen , Zhang, Ning , Sun, Guangyan , Cha, Joonseok , Wang, Ying , Liu, Yi , He, Qun
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1091-6490 ; PMID: 24277852 Version:1 ; DOI: 10.1073/pnas.1315133110
Link: http://pubmed.gov/24277852
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recordid: medline24277852
title: Suppression of WC-independent frequency transcription by RCO-1 is essential for Neurospora circadian clock
format: Article
creator:
  • Zhou, Zhipeng
  • Liu, Xiao
  • Hu, Qiwen
  • Zhang, Ning
  • Sun, Guangyan
  • Cha, Joonseok
  • Wang, Ying
  • Liu, Yi
  • He, Qun
subjects:
  • H3k36me3
  • Rco-1/Tup1
  • Clock Gene Frq
  • Transcriptional Repression
  • Circadian Clocks -- Physiology
  • Circadian Rhythm -- Physiology
  • DNA-Binding Proteins -- Metabolism
  • Fungal Proteins -- Metabolism
  • Gene Expression Regulation -- Physiology
  • Neurospora -- Physiology
  • Repressor Proteins -- Deficiency
  • Transcription Factors -- Metabolism
ispartof: Proceedings of the National Academy of Sciences of the United States of America, 10 December 2013, Vol.110(50), pp.E4867-74
description: Rhythmic activation and repression of clock gene transcription is essential for the functions of eukaryotic circadian clocks. In the Neurospora circadian oscillator, frequency (frq) transcription requires the WHITE COLLAR (WC) complex. Here, we show that the transcriptional corepressor regulation of conidiation-1 (RCO-1) is essential for clock function by regulating frq transcription. In rco-1 mutants, both overt and molecular rhythms are abolished, frq mRNA levels are constantly high, and WC binding to the frq promoter is dramatically reduced. Surprisingly, frq mRNA levels were constantly high in the rco-1 wc double mutants, indicating that RCO-1 suppresses WC-independent transcription and promotes WC complex binding to the frq promoter. Furthermore, RCO-1 is required for maintaining normal chromatin structure at the frq locus. Deletion of H3K36 methyltransferase su(var)3-9-enhancer-of-zeste-trithorax-2 (SET-2) or the chromatin remodeling factor CHD-1 leads to WC-independent frq transcription...
language: eng
source:
identifier: E-ISSN: 1091-6490 ; PMID: 24277852 Version:1 ; DOI: 10.1073/pnas.1315133110
fulltext: fulltext
issn:
  • 10916490
  • 1091-6490
url: Link


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titleSuppression of WC-independent frequency transcription by RCO-1 is essential for Neurospora circadian clock
creatorZhou, Zhipeng ; Liu, Xiao ; Hu, Qiwen ; Zhang, Ning ; Sun, Guangyan ; Cha, Joonseok ; Wang, Ying ; Liu, Yi ; He, Qun
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subjectH3k36me3 ; Rco-1/Tup1 ; Clock Gene Frq ; Transcriptional Repression ; Circadian Clocks -- Physiology ; Circadian Rhythm -- Physiology ; DNA-Binding Proteins -- Metabolism ; Fungal Proteins -- Metabolism ; Gene Expression Regulation -- Physiology ; Neurospora -- Physiology ; Repressor Proteins -- Deficiency ; Transcription Factors -- Metabolism
descriptionRhythmic activation and repression of clock gene transcription is essential for the functions of eukaryotic circadian clocks. In the Neurospora circadian oscillator, frequency (frq) transcription requires the WHITE COLLAR (WC) complex. Here, we show that the transcriptional corepressor regulation of conidiation-1 (RCO-1) is essential for clock function by regulating frq transcription. In rco-1 mutants, both overt and molecular rhythms are abolished, frq mRNA levels are constantly high, and WC binding to the frq promoter is dramatically reduced. Surprisingly, frq mRNA levels were constantly high in the rco-1 wc double mutants, indicating that RCO-1 suppresses WC-independent transcription and promotes WC complex binding to the frq promoter. Furthermore, RCO-1 is required for maintaining normal chromatin structure at the frq locus. Deletion of H3K36 methyltransferase su(var)3-9-enhancer-of-zeste-trithorax-2 (SET-2) or the chromatin remodeling factor CHD-1 leads to WC-independent frq transcription...
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titleSuppression of WC-independent frequency transcription by RCO-1 is essential for Neurospora circadian clock
descriptionRhythmic activation and repression of clock gene transcription is essential for the functions of eukaryotic circadian clocks. In the Neurospora circadian oscillator, frequency (frq) transcription requires the WHITE COLLAR (WC) complex. Here, we show that the transcriptional corepressor regulation of conidiation-1 (RCO-1) is essential for clock function by regulating frq transcription. In rco-1 mutants, both overt and molecular rhythms are abolished, frq mRNA levels are constantly high, and WC binding to the frq promoter is dramatically reduced. Surprisingly, frq mRNA levels were constantly high in the rco-1 wc double mutants, indicating that RCO-1 suppresses WC-independent transcription and promotes WC complex binding to the frq promoter. Furthermore, RCO-1 is required for maintaining normal chromatin structure at the frq locus. Deletion of H3K36 methyltransferase su(var)3-9-enhancer-of-zeste-trithorax-2 (SET-2) or the chromatin remodeling factor CHD-1 leads to WC-independent frq transcription...
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abstractRhythmic activation and repression of clock gene transcription is essential for the functions of eukaryotic circadian clocks. In the Neurospora circadian oscillator, frequency (frq) transcription requires the WHITE COLLAR (WC) complex. Here, we show that the transcriptional corepressor regulation of conidiation-1 (RCO-1) is essential for clock function by regulating frq transcription. In rco-1 mutants, both overt and molecular rhythms are abolished, frq mRNA levels are constantly high, and WC binding to the frq promoter is dramatically reduced. Surprisingly, frq mRNA levels were constantly high in the rco-1 wc double mutants, indicating that RCO-1 suppresses WC-independent transcription and promotes WC complex binding to the frq promoter. Furthermore, RCO-1 is required for maintaining normal chromatin structure at the frq locus. Deletion of H3K36 methyltransferase su(var)3-9-enhancer-of-zeste-trithorax-2 (SET-2) or the chromatin remodeling factor CHD-1 leads to WC-independent frq transcription...
doi10.1073/pnas.1315133110
pmid24277852
date2013-12-10