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Spatial repolarization heterogeneity detected by magnetocardiography correlates with cardiac iron overload and adverse cardiac events in beta-thalassemia major

Patients with transfusion-dependent beta-thalassemia major (TM) are at risk for myocardial iron overload and cardiac complications. Spatial repolarization heterogeneity is known to be elevated in patients with certain cardiac diseases, but little is known in TM patients. The purpose of this study wa... Full description

Journal Title: PloS one 2014, Vol.9(1), pp.e86524
Main Author: Chen, Chun-An
Other Authors: Lu, Meng-Yao , Peng, Shinn-Forng , Lin, Kai-Hsin , Chang, Hsiu-Hao , Yang, Yung-Li , Jou, Shiann-Tarng , Lin, Dong-Tsamn , Liu, Yen-Bin , Horng, Herng-Er , Yang, Hong-Chang , Wang, Jou-Kou , Wu, Mei-Hwan , Wu, Chau-Chung
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1932-6203 ; PMID: 24475137 Version:1 ; DOI: 10.1371/journal.pone.0086524
Link: http://pubmed.gov/24475137
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recordid: medline24475137
title: Spatial repolarization heterogeneity detected by magnetocardiography correlates with cardiac iron overload and adverse cardiac events in beta-thalassemia major
format: Article
creator:
  • Chen, Chun-An
  • Lu, Meng-Yao
  • Peng, Shinn-Forng
  • Lin, Kai-Hsin
  • Chang, Hsiu-Hao
  • Yang, Yung-Li
  • Jou, Shiann-Tarng
  • Lin, Dong-Tsamn
  • Liu, Yen-Bin
  • Horng, Herng-Er
  • Yang, Hong-Chang
  • Wang, Jou-Kou
  • Wu, Mei-Hwan
  • Wu, Chau-Chung
subjects:
  • Heart Conduction System -- Physiology
  • Heart Diseases -- Etiology
  • Iron Overload -- Metabolism
  • Myocardium -- Metabolism
  • Ventricular Function, Left -- Physiology
  • Beta-Thalassemia -- Complications
ispartof: PloS one, 2014, Vol.9(1), pp.e86524
description: Patients with transfusion-dependent beta-thalassemia major (TM) are at risk for myocardial iron overload and cardiac complications. Spatial repolarization heterogeneity is known to be elevated in patients with certain cardiac diseases, but little is known in TM patients. The purpose of this study was to evaluate spatial repolarization heterogeneity in patients with TM, and to investigate the relationships between spatial repolarization heterogeneity, cardiac iron load, and adverse cardiac events. Fifty patients with TM and 55 control subjects received 64-channel magnetocardiography (MCG) to determine spatial repolarization heterogeneity, which was evaluated by a smoothness index of QTc (SI-QTc), a standard deviation of QTc (SD-QTc), and a QTc dispersion. Left ventricular function and myocardial T2* values were assessed by cardiac magnetic resonance. Patients with TM had significantly greater SI-QTc, SD-QTc, and QTc dispersion compared to the control subjects (all p values
language: eng
source:
identifier: E-ISSN: 1932-6203 ; PMID: 24475137 Version:1 ; DOI: 10.1371/journal.pone.0086524
fulltext: fulltext
issn:
  • 19326203
  • 1932-6203
url: Link


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titleSpatial repolarization heterogeneity detected by magnetocardiography correlates with cardiac iron overload and adverse cardiac events in beta-thalassemia major
creatorChen, Chun-An ; Lu, Meng-Yao ; Peng, Shinn-Forng ; Lin, Kai-Hsin ; Chang, Hsiu-Hao ; Yang, Yung-Li ; Jou, Shiann-Tarng ; Lin, Dong-Tsamn ; Liu, Yen-Bin ; Horng, Herng-Er ; Yang, Hong-Chang ; Wang, Jou-Kou ; Wu, Mei-Hwan ; Wu, Chau-Chung
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subjectHeart Conduction System -- Physiology ; Heart Diseases -- Etiology ; Iron Overload -- Metabolism ; Myocardium -- Metabolism ; Ventricular Function, Left -- Physiology ; Beta-Thalassemia -- Complications
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titleSpatial repolarization heterogeneity detected by magnetocardiography correlates with cardiac iron overload and adverse cardiac events in beta-thalassemia major
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titleSpatial repolarization heterogeneity detected by magnetocardiography correlates with cardiac iron overload and adverse cardiac events in beta-thalassemia major
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abstractPatients with transfusion-dependent beta-thalassemia major (TM) are at risk for myocardial iron overload and cardiac complications. Spatial repolarization heterogeneity is known to be elevated in patients with certain cardiac diseases, but little is known in TM patients. The purpose of this study was to evaluate spatial repolarization heterogeneity in patients with TM, and to investigate the relationships between spatial repolarization heterogeneity, cardiac iron load, and adverse cardiac events.
doi10.1371/journal.pone.0086524
pmid24475137