schliessen

Filtern

 

Bibliotheken

Signature of circulating microRNAs in osteoarthritis

Osteoarthritis is the most common form of arthritis and a major socioeconomic burden. Our study is the first to explore the association between serum microRNA levels and the development of severe osteoarthritis of the knee and hip joint in the general population. We followed 816 Caucasian individual... Full description

Journal Title: Annals of the rheumatic diseases March 2015, Vol.74(3), pp.e18
Main Author: Beyer, Christian
Other Authors: Zampetaki, Anna , Lin, Neng-Yu , Kleyer, Arnd , Perricone, Carlo , Iagnocco, Annamaria , Distler, Alfiya , Langley, Sarah R , Gelse, Kolja , Sesselmann, Stefan , Lorenzini, Rolando , Niemeier, Andreas , Swoboda, Bernd , Distler, Jörg H W , Santer, Peter , Egger, Georg , Willeit, Johann , Mayr, Manuel , Schett
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1468-2060 ; PMID: 24515954 Version:1 ; DOI: 10.1136/annrheumdis-2013-204698
Link: http://pubmed.gov/24515954
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: medline24515954
title: Signature of circulating microRNAs in osteoarthritis
format: Article
creator:
  • Beyer, Christian
  • Zampetaki, Anna
  • Lin, Neng-Yu
  • Kleyer, Arnd
  • Perricone, Carlo
  • Iagnocco, Annamaria
  • Distler, Alfiya
  • Langley, Sarah R
  • Gelse, Kolja
  • Sesselmann, Stefan
  • Lorenzini, Rolando
  • Niemeier, Andreas
  • Swoboda, Bernd
  • Distler, Jörg H W
  • Santer, Peter
  • Egger, Georg
  • Willeit, Johann
  • Mayr, Manuel
  • Schett
subjects:
  • Knee Osteoarthritis
  • Orthopedic Surgery
  • Osteoarthritis
  • Micrornas -- Blood
  • Osteoarthritis, Hip -- Genetics
  • Osteoarthritis, Knee -- Genetics
ispartof: Annals of the rheumatic diseases, March 2015, Vol.74(3), pp.e18
description: Osteoarthritis is the most common form of arthritis and a major socioeconomic burden. Our study is the first to explore the association between serum microRNA levels and the development of severe osteoarthritis of the knee and hip joint in the general population. We followed 816 Caucasian individuals from 1995 to 2010 and assessed joint arthroplasty as a definitive outcome of severe osteoarthritis of the knee and hip. After a microarray screen, we validated 12 microRNAs by real-time PCR in the entire cohort at baseline. In Cox regression analysis, three microRNAs were associated with severe knee and hip osteoarthritis. let-7e was a negative predictor for total joint arthroplasty with an adjusted HR of 0.75 (95% CI 0.58 to 0.96; p=0.021) when normalised to U6, and 0.76 (95% CI 0.6 to 0.97; p=0.026) after normalisation to the Ct average. miRNA-454 was inversely correlated with severe knee or hip osteoarthritis with an adjusted HR of 0.77 (95% CI 0.61 to 0.97; p=0.028) when normalised to U6. This correlation was lost when data were normalised to Ct average (p=0.118). Finally, miRNA-885-5p showed a trend towards a positive relationship with arthroplasty when normalised to U6 (HR 1.24; 95% CI 0.95 to 1.62; p=0.107) or to Ct average (HR 1.30; 95% CI 0.99 to 1.70; p=0.056). Our study is the first to identify differentially expressed circulating microRNAs in osteoarthritis patients necessitating arthroplasty in a large, population-based cohort. Among these microRNAs, let-7e emerged as potential predictor for severe knee or hip osteoarthritis.
language: eng
source:
identifier: E-ISSN: 1468-2060 ; PMID: 24515954 Version:1 ; DOI: 10.1136/annrheumdis-2013-204698
fulltext: fulltext
issn:
  • 14682060
  • 1468-2060
url: Link


@attributes
ID1131715106
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordid24515954
sourceidmedline
recordidTN_medline24515954
sourceformatXML
sourcesystemPC
pqid1808632645
galeid403023005
display
typearticle
titleSignature of circulating microRNAs in osteoarthritis
creatorBeyer, Christian ; Zampetaki, Anna ; Lin, Neng-Yu ; Kleyer, Arnd ; Perricone, Carlo ; Iagnocco, Annamaria ; Distler, Alfiya ; Langley, Sarah R ; Gelse, Kolja ; Sesselmann, Stefan ; Lorenzini, Rolando ; Niemeier, Andreas ; Swoboda, Bernd ; Distler, Jörg H W ; Santer, Peter ; Egger, Georg ; Willeit, Johann ; Mayr, Manuel ; Schett
ispartofAnnals of the rheumatic diseases, March 2015, Vol.74(3), pp.e18
identifier
subjectKnee Osteoarthritis ; Orthopedic Surgery ; Osteoarthritis ; Micrornas -- Blood ; Osteoarthritis, Hip -- Genetics ; Osteoarthritis, Knee -- Genetics
descriptionOsteoarthritis is the most common form of arthritis and a major socioeconomic burden. Our study is the first to explore the association between serum microRNA levels and the development of severe osteoarthritis of the knee and hip joint in the general population. We followed 816 Caucasian individuals from 1995 to 2010 and assessed joint arthroplasty as a definitive outcome of severe osteoarthritis of the knee and hip. After a microarray screen, we validated 12 microRNAs by real-time PCR in the entire cohort at baseline. In Cox regression analysis, three microRNAs were associated with severe knee and hip osteoarthritis. let-7e was a negative predictor for total joint arthroplasty with an adjusted HR of 0.75 (95% CI 0.58 to 0.96; p=0.021) when normalised to U6, and 0.76 (95% CI 0.6 to 0.97; p=0.026) after normalisation to the Ct average. miRNA-454 was inversely correlated with severe knee or hip osteoarthritis with an adjusted HR of 0.77 (95% CI 0.61 to 0.97; p=0.028) when normalised to U6. This correlation was lost when data were normalised to Ct average (p=0.118). Finally, miRNA-885-5p showed a trend towards a positive relationship with arthroplasty when normalised to U6 (HR 1.24; 95% CI 0.95 to 1.62; p=0.107) or to Ct average (HR 1.30; 95% CI 0.99 to 1.70; p=0.056). Our study is the first to identify differentially expressed circulating microRNAs in osteoarthritis patients necessitating arthroplasty in a large, population-based cohort. Among these microRNAs, let-7e emerged as potential predictor for severe knee or hip osteoarthritis.
languageeng
source
version6
lds50peer_reviewed
links
openurl$$Topenurl_article
backlink$$Uhttp://pubmed.gov/24515954$$EView_this_record_in_MEDLINE/PubMed
openurlfulltext$$Topenurlfull_article
addlink$$Uhttp://exlibris-pub.s3.amazonaws.com/aboutMedline.html$$EView_the_MEDLINE/PubMed_Copyright_Statement
search
creatorcontrib
0Beyer, Christian
1Zampetaki, Anna
2Lin, Neng-Yu
3Kleyer, Arnd
4Perricone, Carlo
5Iagnocco, Annamaria
6Distler, Alfiya
7Langley, Sarah R
8Gelse, Kolja
9Sesselmann, Stefan
10Lorenzini, Rolando
11Niemeier, Andreas
12Swoboda, Bernd
13Distler, Jörg H W
14Santer, Peter
15Egger, Georg
16Willeit, Johann
17Mayr, Manuel
18Schett, Georg
19Kiechl, Stefan
titleSignature of circulating microRNAs in osteoarthritis
description
0Osteoarthritis is the most common form of arthritis and a major socioeconomic burden. Our study is the first to explore the association between serum microRNA levels and the development of severe osteoarthritis of the knee and hip joint in the general population.
1We followed 816 Caucasian individuals from 1995 to 2010 and assessed joint arthroplasty as a definitive outcome of severe osteoarthritis of the knee and hip. After a microarray screen, we validated 12 microRNAs by real-time PCR in the entire cohort at baseline.
2In Cox regression analysis, three microRNAs were associated with severe knee and hip osteoarthritis. let-7e was a negative predictor for total joint arthroplasty with an adjusted HR of 0.75 (95% CI 0.58 to 0.96; p=0.021) when normalised to U6, and 0.76 (95% CI 0.6 to 0.97; p=0.026) after normalisation to the Ct average. miRNA-454 was inversely correlated with severe knee or hip osteoarthritis with an adjusted HR of 0.77 (95% CI 0.61 to 0.97; p=0.028) when normalised to U6. This correlation was lost when data were normalised to Ct average (p=0.118). Finally, miRNA-885-5p showed a trend towards a positive relationship with arthroplasty when normalised to U6 (HR 1.24; 95% CI 0.95 to 1.62; p=0.107) or to Ct average (HR 1.30; 95% CI 0.99 to 1.70; p=0.056).
3Our study is the first to identify differentially expressed circulating microRNAs in osteoarthritis patients necessitating arthroplasty in a large, population-based cohort. Among these microRNAs, let-7e emerged as potential predictor for severe knee or hip osteoarthritis.
subject
0Knee Osteoarthritis
1Orthopedic Surgery
2Osteoarthritis
3Micrornas -- Blood
4Osteoarthritis, Hip -- Genetics
5Osteoarthritis, Knee -- Genetics
general
024515954
1English
2MEDLINE/PubMed (U.S. National Library of Medicine)
310.1136/annrheumdis-2013-204698
4MEDLINE/PubMed (NLM)
sourceidmedline
recordidmedline24515954
issn
014682060
11468-2060
rsrctypearticle
creationdate2015
addtitleAnnals of the rheumatic diseases
searchscope
0medline
1nlm_medline
2MEDLINE
scope
0medline
1nlm_medline
2MEDLINE
lsr41201503
citationpf e18 vol 74 issue 3
startdate20150301
enddate20150331
lsr30VSR-Enriched:[galeid, pqid]
sort
titleSignature of circulating microRNAs in osteoarthritis
authorBeyer, Christian ; Zampetaki, Anna ; Lin, Neng-Yu ; Kleyer, Arnd ; Perricone, Carlo ; Iagnocco, Annamaria ; Distler, Alfiya ; Langley, Sarah R ; Gelse, Kolja ; Sesselmann, Stefan ; Lorenzini, Rolando ; Niemeier, Andreas ; Swoboda, Bernd ; Distler, Jörg H W ; Santer, Peter ; Egger, Georg ; Willeit, Johann ; Mayr, Manuel ; Schett
creationdate20150300
lso0120150300
facets
frbrgroupid7729837687360453175
frbrtype5
newrecords20190701
languageeng
creationdate2015
topic
0Knee Osteoarthritis
1Orthopedic Surgery
2Osteoarthritis
3Micrornas–Blood
4Osteoarthritis, Hip–Genetics
5Osteoarthritis, Knee–Genetics
collectionMEDLINE/PubMed (NLM)
prefilterarticles
rsrctypearticles
creatorcontrib
0Beyer, Christian
1Zampetaki, Anna
2Lin, Neng-Yu
3Kleyer, Arnd
4Perricone, Carlo
5Iagnocco, Annamaria
6Distler, Alfiya
7Langley, Sarah R
8Gelse, Kolja
9Sesselmann, Stefan
10Lorenzini, Rolando
11Niemeier, Andreas
12Swoboda, Bernd
13Distler, Jörg H W
14Santer, Peter
15Egger, Georg
16Willeit, Johann
17Mayr, Manuel
18Schett, Georg
19Kiechl, Stefan
jtitleAnnals Of The Rheumatic Diseases
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
aulast
0Beyer
1Zampetaki
2Lin
3Kleyer
4Perricone
5Iagnocco
6Distler
7Langley
8Gelse
9Sesselmann
10Lorenzini
11Niemeier
12Swoboda
13Santer
14Egger
15Willeit
16Mayr
17Schett
18Kiechl
aufirst
0Christian
1Anna
2Neng-Yu
3Arnd
4Carlo
5Annamaria
6Alfiya
7Sarah R
8Kolja
9Stefan
10Rolando
11Andreas
12Bernd
13Jörg H W
14Peter
15Georg
16Johann
17Manuel
au
0Beyer, Christian
1Zampetaki, Anna
2Lin, Neng-Yu
3Kleyer, Arnd
4Perricone, Carlo
5Iagnocco, Annamaria
6Distler, Alfiya
7Langley, Sarah R
8Gelse, Kolja
9Sesselmann, Stefan
10Lorenzini, Rolando
11Niemeier, Andreas
12Swoboda, Bernd
13Distler, Jörg H W
14Santer, Peter
15Egger, Georg
16Willeit, Johann
17Mayr, Manuel
18Schett, Georg
19Kiechl, Stefan
atitleSignature of circulating microRNAs in osteoarthritis
jtitleAnnals of the rheumatic diseases
risdate201503
volume74
issue3
spagee18
pagese18
issn0003-4967
eissn1468-2060
formatjournal
genrearticle
ristypeJOUR
abstractOsteoarthritis is the most common form of arthritis and a major socioeconomic burden. Our study is the first to explore the association between serum microRNA levels and the development of severe osteoarthritis of the knee and hip joint in the general population.
doi10.1136/annrheumdis-2013-204698
pmid24515954
date2015-03