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In situ growth of porous platinum nanoparticles on graphene oxide for colorimetric detection of cancer cells

A green approach is proposed for in situ growth of porous platinum nanoparticles on graphene oxide (PtNPs/GO). The resulting nanocomposite has been proven to function as peroxidase mimetics that can catalyze the reaction of peroxidase substrate in the presence of hydrogen peroxide. On the basis of t... Full description

Journal Title: Analytical chemistry 04 March 2014, Vol.86(5), pp.2711-8
Main Author: Zhang, Ling-Na
Other Authors: Deng, Hao-Hua , Lin, Feng-Lin , Xu, Xiong-Wei , Weng, Shao-Huang , Liu, Ai-Lin , Lin, Xin-Hua , Xia, Xing-Hua , Chen, Wei
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1520-6882 ; PMID: 24524671 Version:1 ; DOI: 10.1021/ac404104j
Link: http://pubmed.gov/24524671
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recordid: medline24524671
title: In situ growth of porous platinum nanoparticles on graphene oxide for colorimetric detection of cancer cells
format: Article
creator:
  • Zhang, Ling-Na
  • Deng, Hao-Hua
  • Lin, Feng-Lin
  • Xu, Xiong-Wei
  • Weng, Shao-Huang
  • Liu, Ai-Lin
  • Lin, Xin-Hua
  • Xia, Xing-Hua
  • Chen, Wei
subjects:
  • Colorimetry
  • Metal Nanoparticles
  • Graphite -- Chemistry
  • Platinum -- Chemistry
ispartof: Analytical chemistry, 04 March 2014, Vol.86(5), pp.2711-8
description: A green approach is proposed for in situ growth of porous platinum nanoparticles on graphene oxide (PtNPs/GO). The resulting nanocomposite has been proven to function as peroxidase mimetics that can catalyze the reaction of peroxidase substrate in the presence of hydrogen peroxide. On the basis of the peroxidase-like activity, we used the PtNPs/GO as a signal transducer to develop a colorimetric assay for the direct detection of cancer cells. By using folic acid as a recognition element, a total of 125 cancer cells (MCF-7) can be distinguished by naked-eye observation. We envision that this nanomaterial could be used as a power tool for a wide range of potential applications in biotechnology and medicine.
language: eng
source:
identifier: E-ISSN: 1520-6882 ; PMID: 24524671 Version:1 ; DOI: 10.1021/ac404104j
fulltext: fulltext
issn:
  • 15206882
  • 1520-6882
url: Link


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titleIn situ growth of porous platinum nanoparticles on graphene oxide for colorimetric detection of cancer cells
creatorZhang, Ling-Na ; Deng, Hao-Hua ; Lin, Feng-Lin ; Xu, Xiong-Wei ; Weng, Shao-Huang ; Liu, Ai-Lin ; Lin, Xin-Hua ; Xia, Xing-Hua ; Chen, Wei
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subjectColorimetry ; Metal Nanoparticles ; Graphite -- Chemistry ; Platinum -- Chemistry
descriptionA green approach is proposed for in situ growth of porous platinum nanoparticles on graphene oxide (PtNPs/GO). The resulting nanocomposite has been proven to function as peroxidase mimetics that can catalyze the reaction of peroxidase substrate in the presence of hydrogen peroxide. On the basis of the peroxidase-like activity, we used the PtNPs/GO as a signal transducer to develop a colorimetric assay for the direct detection of cancer cells. By using folic acid as a recognition element, a total of 125 cancer cells (MCF-7) can be distinguished by naked-eye observation. We envision that this nanomaterial could be used as a power tool for a wide range of potential applications in biotechnology and medicine.
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titleIn situ growth of porous platinum nanoparticles on graphene oxide for colorimetric detection of cancer cells
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abstractA green approach is proposed for in situ growth of porous platinum nanoparticles on graphene oxide (PtNPs/GO). The resulting nanocomposite has been proven to function as peroxidase mimetics that can catalyze the reaction of peroxidase substrate in the presence of hydrogen peroxide. On the basis of the peroxidase-like activity, we used the PtNPs/GO as a signal transducer to develop a colorimetric assay for the direct detection of cancer cells. By using folic acid as a recognition element, a total of 125 cancer cells (MCF-7) can be distinguished by naked-eye observation. We envision that this nanomaterial could be used as a power tool for a wide range of potential applications in biotechnology and medicine.
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