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Requirement of MEF2A, C, and D for skeletal muscle regeneration

Regeneration of adult skeletal muscle following injury occurs through the activation of satellite cells, an injury-sensitive muscle stem cell population that proliferates, differentiates, and fuses with injured myofibers. Members of the myocyte enhancer factor 2 (MEF2) family of transcription factor... Full description

Journal Title: Proceedings of the National Academy of Sciences of the United States of America 18 March 2014, Vol.111(11), pp.4109-14
Main Author: Liu, Ning
Other Authors: Nelson, Benjamin R , Bezprozvannaya, Svetlana , Shelton, John M , Richardson, James A , Bassel-Duby, Rhonda , Olson, Eric N
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1091-6490 ; PMID: 24591619 Version:1 ; DOI: 10.1073/pnas.1401732111
Link: http://pubmed.gov/24591619
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recordid: medline24591619
title: Requirement of MEF2A, C, and D for skeletal muscle regeneration
format: Article
creator:
  • Liu, Ning
  • Nelson, Benjamin R
  • Bezprozvannaya, Svetlana
  • Shelton, John M
  • Richardson, James A
  • Bassel-Duby, Rhonda
  • Olson, Eric N
subjects:
  • Myogenesis
  • Myogenic Regulatory Factor
  • Myotube
  • Gene Expression Regulation -- Genetics
  • Muscle, Skeletal -- Growth & Development
  • Regeneration -- Physiology
  • Satellite Cells, Skeletal Muscle -- Metabolism
ispartof: Proceedings of the National Academy of Sciences of the United States of America, 18 March 2014, Vol.111(11), pp.4109-14
description: Regeneration of adult skeletal muscle following injury occurs through the activation of satellite cells, an injury-sensitive muscle stem cell population that proliferates, differentiates, and fuses with injured myofibers. Members of the myocyte enhancer factor 2 (MEF2) family of transcription factors play essential roles in muscle differentiation during embryogenesis, but their potential contributions to adult muscle regeneration have not been systematically explored. To investigate the potential involvement of MEF2 factors in muscle regeneration, we conditionally deleted the Mef2a, c, and d genes, singly and in combination, within satellite cells in mice, using tamoxifen-inducible Cre recombinase under control of the satellite cell-specific Pax7 promoter. We show that deletion of individual Mef2 genes has no effect on muscle regeneration in response to cardiotoxin injury. However, combined deletion of the Mef2a, c, and d genes results in a blockade to regeneration. Satellite cell-derived...
language: eng
source:
identifier: E-ISSN: 1091-6490 ; PMID: 24591619 Version:1 ; DOI: 10.1073/pnas.1401732111
fulltext: fulltext
issn:
  • 10916490
  • 1091-6490
url: Link


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titleRequirement of MEF2A, C, and D for skeletal muscle regeneration
creatorLiu, Ning ; Nelson, Benjamin R ; Bezprozvannaya, Svetlana ; Shelton, John M ; Richardson, James A ; Bassel-Duby, Rhonda ; Olson, Eric N
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subjectMyogenesis ; Myogenic Regulatory Factor ; Myotube ; Gene Expression Regulation -- Genetics ; Muscle, Skeletal -- Growth & Development ; Regeneration -- Physiology ; Satellite Cells, Skeletal Muscle -- Metabolism
descriptionRegeneration of adult skeletal muscle following injury occurs through the activation of satellite cells, an injury-sensitive muscle stem cell population that proliferates, differentiates, and fuses with injured myofibers. Members of the myocyte enhancer factor 2 (MEF2) family of transcription factors play essential roles in muscle differentiation during embryogenesis, but their potential contributions to adult muscle regeneration have not been systematically explored. To investigate the potential involvement of MEF2 factors in muscle regeneration, we conditionally deleted the Mef2a, c, and d genes, singly and in combination, within satellite cells in mice, using tamoxifen-inducible Cre recombinase under control of the satellite cell-specific Pax7 promoter. We show that deletion of individual Mef2 genes has no effect on muscle regeneration in response to cardiotoxin injury. However, combined deletion of the Mef2a, c, and d genes results in a blockade to regeneration. Satellite cell-derived...
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titleRequirement of MEF2A, C, and D for skeletal muscle regeneration
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abstractRegeneration of adult skeletal muscle following injury occurs through the activation of satellite cells, an injury-sensitive muscle stem cell population that proliferates, differentiates, and fuses with injured myofibers. Members of the myocyte enhancer factor 2 (MEF2) family of transcription factors play essential roles in muscle differentiation during embryogenesis, but their potential contributions to adult muscle regeneration have not been systematically explored. To investigate the potential involvement of MEF2 factors in muscle regeneration, we conditionally deleted the Mef2a, c, and d genes, singly and in combination, within satellite cells in mice, using tamoxifen-inducible Cre recombinase under control of the satellite cell-specific Pax7 promoter. We show that deletion of individual Mef2 genes has no effect on muscle regeneration in response to cardiotoxin injury. However, combined deletion of the Mef2a, c, and d genes results in a blockade to regeneration. Satellite cell-derived...
doi10.1073/pnas.1401732111
pmid24591619
date2014-03-18