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Study protocol: The Whitehall II imaging sub-study

The Whitehall II (WHII) study of British civil servants provides a unique source of longitudinal data to investigate key factors hypothesized to affect brain health and cognitive ageing. This paper introduces the multi-modal magnetic resonance imaging (MRI) protocol and cognitive assessment designed... Full description

Journal Title: BMC psychiatry 30 May 2014, Vol.14, pp.159
Main Author: Filippini, Nicola
Other Authors: Zsoldos, Enikő , Haapakoski, Rita , Sexton, Claire E , Mahmood, Abda , Allan, Charlotte L , Topiwala, Anya , Valkanova, Vyara , Brunner, Eric J , Shipley, Martin J , Auerbach, Edward , Moeller, Steen , Uğurbil, Kâmil , Xu, Junqian , Yacoub, Essa , Andersson, Jesper , Bijsterbosch
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1471-244X ; PMID: 24885374 Version:1 ; DOI: 10.1186/1471-244X-14-159
Link: http://pubmed.gov/24885374
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recordid: medline24885374
title: Study protocol: The Whitehall II imaging sub-study
format: Article
creator:
  • Filippini, Nicola
  • Zsoldos, Enikő
  • Haapakoski, Rita
  • Sexton, Claire E
  • Mahmood, Abda
  • Allan, Charlotte L
  • Topiwala, Anya
  • Valkanova, Vyara
  • Brunner, Eric J
  • Shipley, Martin J
  • Auerbach, Edward
  • Moeller, Steen
  • Uğurbil, Kâmil
  • Xu, Junqian
  • Yacoub, Essa
  • Andersson, Jesper
  • Bijsterbosch
subjects:
  • Aging -- Pathology
  • Brain -- Pathology
  • Cognition Disorders -- Pathology
  • Magnetic Resonance Imaging -- Methods
  • Neuroimaging -- Methods
ispartof: BMC psychiatry, 30 May 2014, Vol.14, pp.159
description: The Whitehall II (WHII) study of British civil servants provides a unique source of longitudinal data to investigate key factors hypothesized to affect brain health and cognitive ageing. This paper introduces the multi-modal magnetic resonance imaging (MRI) protocol and cognitive assessment designed to investigate brain health in a random sample of 800 members of the WHII study. A total of 6035 civil servants participated in the WHII Phase 11 clinical examination in 2012-2013. A random sample of these participants was included in a sub-study comprising an MRI brain scan, a detailed clinical and cognitive assessment, and collection of blood and buccal mucosal samples for the characterisation of immune function and associated measures. Data collection for this sub-study started in 2012 and will be completed by 2016. The participants, for whom social and health records have been collected since 1985, were between 60-85 years of age at the time the MRI study started. Here, we describe the pre-specified clinical and cognitive assessment protocols, the state-of-the-art MRI sequences and latest pipelines for analyses of this sub-study. The integration of cutting-edge MRI techniques, clinical and cognitive tests in combination with retrospective data on social, behavioural and biological variables during the preceding 25 years from a well-established longitudinal epidemiological study (WHII cohort) will provide a unique opportunity to examine brain structure and function in relation to age-related diseases and the modifiable and non-modifiable factors affecting resilience against and vulnerability to adverse brain changes.
language: eng
source:
identifier: E-ISSN: 1471-244X ; PMID: 24885374 Version:1 ; DOI: 10.1186/1471-244X-14-159
fulltext: fulltext
issn:
  • 1471244X
  • 1471-244X
url: Link


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titleStudy protocol: The Whitehall II imaging sub-study
creatorFilippini, Nicola ; Zsoldos, Enikő ; Haapakoski, Rita ; Sexton, Claire E ; Mahmood, Abda ; Allan, Charlotte L ; Topiwala, Anya ; Valkanova, Vyara ; Brunner, Eric J ; Shipley, Martin J ; Auerbach, Edward ; Moeller, Steen ; Uğurbil, Kâmil ; Xu, Junqian ; Yacoub, Essa ; Andersson, Jesper ; Bijsterbosch
ispartofBMC psychiatry, 30 May 2014, Vol.14, pp.159
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subjectAging -- Pathology ; Brain -- Pathology ; Cognition Disorders -- Pathology ; Magnetic Resonance Imaging -- Methods ; Neuroimaging -- Methods
descriptionThe Whitehall II (WHII) study of British civil servants provides a unique source of longitudinal data to investigate key factors hypothesized to affect brain health and cognitive ageing. This paper introduces the multi-modal magnetic resonance imaging (MRI) protocol and cognitive assessment designed to investigate brain health in a random sample of 800 members of the WHII study. A total of 6035 civil servants participated in the WHII Phase 11 clinical examination in 2012-2013. A random sample of these participants was included in a sub-study comprising an MRI brain scan, a detailed clinical and cognitive assessment, and collection of blood and buccal mucosal samples for the characterisation of immune function and associated measures. Data collection for this sub-study started in 2012 and will be completed by 2016. The participants, for whom social and health records have been collected since 1985, were between 60-85 years of age at the time the MRI study started. Here, we describe the pre-specified clinical and cognitive assessment protocols, the state-of-the-art MRI sequences and latest pipelines for analyses of this sub-study. The integration of cutting-edge MRI techniques, clinical and cognitive tests in combination with retrospective data on social, behavioural and biological variables during the preceding 25 years from a well-established longitudinal epidemiological study (WHII cohort) will provide a unique opportunity to examine brain structure and function in relation to age-related diseases and the modifiable and non-modifiable factors affecting resilience against and vulnerability to adverse brain changes.
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25Smith, Stephen M
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1A total of 6035 civil servants participated in the WHII Phase 11 clinical examination in 2012-2013. A random sample of these participants was included in a sub-study comprising an MRI brain scan, a detailed clinical and cognitive assessment, and collection of blood and buccal mucosal samples for the characterisation of immune function and associated measures. Data collection for this sub-study started in 2012 and will be completed by 2016. The participants, for whom social and health records have been collected since 1985, were between 60-85 years of age at the time the MRI study started. Here, we describe the pre-specified clinical and cognitive assessment protocols, the state-of-the-art MRI sequences and latest pipelines for analyses of this sub-study.
2The integration of cutting-edge MRI techniques, clinical and cognitive tests in combination with retrospective data on social, behavioural and biological variables during the preceding 25 years from a well-established longitudinal epidemiological study (WHII cohort) will provide a unique opportunity to examine brain structure and function in relation to age-related diseases and the modifiable and non-modifiable factors affecting resilience against and vulnerability to adverse brain changes.
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authorFilippini, Nicola ; Zsoldos, Enikő ; Haapakoski, Rita ; Sexton, Claire E ; Mahmood, Abda ; Allan, Charlotte L ; Topiwala, Anya ; Valkanova, Vyara ; Brunner, Eric J ; Shipley, Martin J ; Auerbach, Edward ; Moeller, Steen ; Uğurbil, Kâmil ; Xu, Junqian ; Yacoub, Essa ; Andersson, Jesper ; Bijsterbosch
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25Smith, Stephen M
26Geddes, John R
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abstractThe Whitehall II (WHII) study of British civil servants provides a unique source of longitudinal data to investigate key factors hypothesized to affect brain health and cognitive ageing. This paper introduces the multi-modal magnetic resonance imaging (MRI) protocol and cognitive assessment designed to investigate brain health in a random sample of 800 members of the WHII study.
doi10.1186/1471-244X-14-159
pmid24885374
issue1
date2014-05-30