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CLIC4, ERp29, and Smac/DIABLO derived from metastatic cancer stem-like cells stratify prognostic risks of colorectal cancer

Cancer stem-like cells have been well accepted to be involved in recurrence and metastasis of cancers, but the prognostic potential of biomarkers integrating with metastasis and cancer stem-like cells for colorectal cancer is unclear. We identified three proteins, CLIC4, ERp29, and Smac/DIABLO, from... Full description

Journal Title: Clinical cancer research : an official journal of the American Association for Cancer Research 15 July 2014, Vol.20(14), pp.3809-17
Main Author: Deng, Yong-Jian
Other Authors: Tang, Na , Liu, Chao , Zhang, Jiang-Yu , An, Sheng-Li , Peng, Yin-Li , Ma, Li-Li , Li, Guang-Qiu , Jiang, Qiang , Hu, Chun-Ting , Wang, Ya-Nan , Liang, Yao-Ze , Bian, Xiu-Wu , Fang, Wei-Gang , Ding, Yan-Qing
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 1078-0432 ; PMID: 24916695 Version:1 ; DOI: 10.1158/1078-0432.CCR-13-1887
Link: http://pubmed.gov/24916695
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recordid: medline24916695
title: CLIC4, ERp29, and Smac/DIABLO derived from metastatic cancer stem-like cells stratify prognostic risks of colorectal cancer
format: Article
creator:
  • Deng, Yong-Jian
  • Tang, Na
  • Liu, Chao
  • Zhang, Jiang-Yu
  • An, Sheng-Li
  • Peng, Yin-Li
  • Ma, Li-Li
  • Li, Guang-Qiu
  • Jiang, Qiang
  • Hu, Chun-Ting
  • Wang, Ya-Nan
  • Liang, Yao-Ze
  • Bian, Xiu-Wu
  • Fang, Wei-Gang
  • Ding, Yan-Qing
subjects:
  • Biomarkers, Tumor -- Metabolism
  • Chloride Channels -- Metabolism
  • Colorectal Neoplasms -- Metabolism
  • Heat-Shock Proteins -- Metabolism
  • Intracellular Signaling Peptides and Proteins -- Metabolism
  • Mitochondrial Proteins -- Metabolism
  • Neoplastic Stem Cells -- Metabolism
ispartof: Clinical cancer research : an official journal of the American Association for Cancer Research, 15 July 2014, Vol.20(14), pp.3809-17
description: Cancer stem-like cells have been well accepted to be involved in recurrence and metastasis of cancers, but the prognostic potential of biomarkers integrating with metastasis and cancer stem-like cells for colorectal cancer is unclear. We identified three proteins, CLIC4, ERp29, and Smac/DIABLO, from metastatic cancer stem-like cells of colorectal cancer and verified the proteins' role in metastatic behaviors. The proteins were detected by IHC in colorectal cancer tumors and matched colonic mucosa from patients with colorectal cancer who underwent radical surgery in the training cohort. The associations between proteins expression levels and five-year disease-specific survival (DSS) were evaluated to predict the survival probability in the training cohort of 421 cases and the validation cohort of 228 cases. A three-protein panel including CLIC4, ERp29, and Smac/DIABLO, which was generated from multivariate analysis by excluding clinicopathologic characteristics from the training cohort, distinguished patients with colorectal cancer into very low-, low-, middle-, and high-risk groups with significant differences in five-year DSS probability (88.6%, 63.3%, 30.4%, 11.4%; P < 0.001). The panel is independent from tumor-node-metastasis staging system and histologic grading to predict prognosis, and also enables classification of validation cohort into four risk stratifications (five-year DSS probability is 98.2%, 80.2%, 25.6%, and 2.7%; P < 0.001). CLIC4, ERp29, and Smac/DIABLO integrated into a novel panel based on cancer stem-like cells in association with metastasis stratify the prognostic risks of colorectal cancer. Prediction of risks with molecular markers will benefit clinicians to make decisions of individual management with postoperative colorectal cancer patients.
language: eng
source:
identifier: ISSN: 1078-0432 ; PMID: 24916695 Version:1 ; DOI: 10.1158/1078-0432.CCR-13-1887
fulltext: fulltext
issn:
  • 10780432
  • 1078-0432
url: Link


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titleCLIC4, ERp29, and Smac/DIABLO derived from metastatic cancer stem-like cells stratify prognostic risks of colorectal cancer
creatorDeng, Yong-Jian ; Tang, Na ; Liu, Chao ; Zhang, Jiang-Yu ; An, Sheng-Li ; Peng, Yin-Li ; Ma, Li-Li ; Li, Guang-Qiu ; Jiang, Qiang ; Hu, Chun-Ting ; Wang, Ya-Nan ; Liang, Yao-Ze ; Bian, Xiu-Wu ; Fang, Wei-Gang ; Ding, Yan-Qing
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subjectBiomarkers, Tumor -- Metabolism ; Chloride Channels -- Metabolism ; Colorectal Neoplasms -- Metabolism ; Heat-Shock Proteins -- Metabolism ; Intracellular Signaling Peptides and Proteins -- Metabolism ; Mitochondrial Proteins -- Metabolism ; Neoplastic Stem Cells -- Metabolism
descriptionCancer stem-like cells have been well accepted to be involved in recurrence and metastasis of cancers, but the prognostic potential of biomarkers integrating with metastasis and cancer stem-like cells for colorectal cancer is unclear. We identified three proteins, CLIC4, ERp29, and Smac/DIABLO, from metastatic cancer stem-like cells of colorectal cancer and verified the proteins' role in metastatic behaviors. The proteins were detected by IHC in colorectal cancer tumors and matched colonic mucosa from patients with colorectal cancer who underwent radical surgery in the training cohort. The associations between proteins expression levels and five-year disease-specific survival (DSS) were evaluated to predict the survival probability in the training cohort of 421 cases and the validation cohort of 228 cases. A three-protein panel including CLIC4, ERp29, and Smac/DIABLO, which was generated from multivariate analysis by excluding clinicopathologic characteristics from the training cohort, distinguished patients with colorectal cancer into very low-, low-, middle-, and high-risk groups with significant differences in five-year DSS probability (88.6%, 63.3%, 30.4%, 11.4%; P < 0.001). The panel is independent from tumor-node-metastasis staging system and histologic grading to predict prognosis, and also enables classification of validation cohort into four risk stratifications (five-year DSS probability is 98.2%, 80.2%, 25.6%, and 2.7%; P < 0.001). CLIC4, ERp29, and Smac/DIABLO integrated into a novel panel based on cancer stem-like cells in association with metastasis stratify the prognostic risks of colorectal cancer. Prediction of risks with molecular markers will benefit clinicians to make decisions of individual management with postoperative colorectal cancer patients.
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titleCLIC4, ERp29, and Smac/DIABLO derived from metastatic cancer stem-like cells stratify prognostic risks of colorectal cancer
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0Cancer stem-like cells have been well accepted to be involved in recurrence and metastasis of cancers, but the prognostic potential of biomarkers integrating with metastasis and cancer stem-like cells for colorectal cancer is unclear.
1We identified three proteins, CLIC4, ERp29, and Smac/DIABLO, from metastatic cancer stem-like cells of colorectal cancer and verified the proteins' role in metastatic behaviors. The proteins were detected by IHC in colorectal cancer tumors and matched colonic mucosa from patients with colorectal cancer who underwent radical surgery in the training cohort. The associations between proteins expression levels and five-year disease-specific survival (DSS) were evaluated to predict the survival probability in the training cohort of 421 cases and the validation cohort of 228 cases.
2A three-protein panel including CLIC4, ERp29, and Smac/DIABLO, which was generated from multivariate analysis by excluding clinicopathologic characteristics from the training cohort, distinguished patients with colorectal cancer into very low-, low-, middle-, and high-risk groups with significant differences in five-year DSS probability (88.6%, 63.3%, 30.4%, 11.4%; P < 0.001). The panel is independent from tumor-node-metastasis staging system and histologic grading to predict prognosis, and also enables classification of validation cohort into four risk stratifications (five-year DSS probability is 98.2%, 80.2%, 25.6%, and 2.7%; P < 0.001).
3CLIC4, ERp29, and Smac/DIABLO integrated into a novel panel based on cancer stem-like cells in association with metastasis stratify the prognostic risks of colorectal cancer. Prediction of risks with molecular markers will benefit clinicians to make decisions of individual management with postoperative colorectal cancer patients.
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abstractCancer stem-like cells have been well accepted to be involved in recurrence and metastasis of cancers, but the prognostic potential of biomarkers integrating with metastasis and cancer stem-like cells for colorectal cancer is unclear.
doi10.1158/1078-0432.CCR-13-1887
pmid24916695
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date2014-07-15