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Trithorax complex component Menin controls differentiation and maintenance of T helper 17 cells

Epigenetic modifications, such as posttranslational modifications of histones, play an important role in gene expression and regulation. These modifications are in part mediated by the Trithorax group (TrxG) complex and the Polycomb group (PcG) complex, which activate and repress transcription, resp... Full description

Journal Title: Proceedings of the National Academy of Sciences of the United States of America 02 September 2014, Vol.111(35), pp.12829-34
Main Author: Watanabe, Yukiko
Other Authors: Onodera, Atsushi , Kanai, Urara , Ichikawa, Tomomi , Obata-Ninomiya, Kazushige , Wada, Tomoko , Kiuchi, Masahiro , Iwamura, Chiaki , Tumes, Damon J , Shinoda, Kenta , Yagi, Ryoji , Motohashi, Shinichiro , Hirahara, Kiyoshi , Nakayama, Toshinori
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1091-6490 ; PMID: 25136117 Version:1 ; DOI: 10.1073/pnas.1321245111
Link: http://pubmed.gov/25136117
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recordid: medline25136117
title: Trithorax complex component Menin controls differentiation and maintenance of T helper 17 cells
format: Article
creator:
  • Watanabe, Yukiko
  • Onodera, Atsushi
  • Kanai, Urara
  • Ichikawa, Tomomi
  • Obata-Ninomiya, Kazushige
  • Wada, Tomoko
  • Kiuchi, Masahiro
  • Iwamura, Chiaki
  • Tumes, Damon J
  • Shinoda, Kenta
  • Yagi, Ryoji
  • Motohashi, Shinichiro
  • Hirahara, Kiyoshi
  • Nakayama, Toshinori
subjects:
  • Rnapii
  • Asthma
  • Chromatin
  • Asthma -- Immunology
  • Epigenesis, Genetic -- Immunology
  • Interleukin-17 -- Immunology
  • Proto-Oncogene Proteins -- Immunology
  • Th17 Cells -- Immunology
ispartof: Proceedings of the National Academy of Sciences of the United States of America, 02 September 2014, Vol.111(35), pp.12829-34
description: Epigenetic modifications, such as posttranslational modifications of histones, play an important role in gene expression and regulation. These modifications are in part mediated by the Trithorax group (TrxG) complex and the Polycomb group (PcG) complex, which activate and repress transcription, respectively. We herein investigate the role of Menin, a component of the TrxG complex in T helper (Th) cell differentiation and show a critical role for Menin in differentiation and maintenance of Th17 cells. Menin(-/-) T cells do not efficiently differentiate into Th17 cells, leaving Th1 and Th2 cell differentiation intact in in vitro cultures. Menin deficiency resulted in the attenuation of Th17-induced airway inflammation. In differentiating Th17 cells, Menin directly bound to the Il17a gene locus and was required for the deposition of permissive histone modifications and recruitment of the RNA polymerase II transcriptional complex. Interestingly, although Menin bound to the Rorc locus, Menin...
language: eng
source:
identifier: E-ISSN: 1091-6490 ; PMID: 25136117 Version:1 ; DOI: 10.1073/pnas.1321245111
fulltext: fulltext
issn:
  • 10916490
  • 1091-6490
url: Link


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titleTrithorax complex component Menin controls differentiation and maintenance of T helper 17 cells
creatorWatanabe, Yukiko ; Onodera, Atsushi ; Kanai, Urara ; Ichikawa, Tomomi ; Obata-Ninomiya, Kazushige ; Wada, Tomoko ; Kiuchi, Masahiro ; Iwamura, Chiaki ; Tumes, Damon J ; Shinoda, Kenta ; Yagi, Ryoji ; Motohashi, Shinichiro ; Hirahara, Kiyoshi ; Nakayama, Toshinori
ispartofProceedings of the National Academy of Sciences of the United States of America, 02 September 2014, Vol.111(35), pp.12829-34
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subjectRnapii ; Asthma ; Chromatin ; Asthma -- Immunology ; Epigenesis, Genetic -- Immunology ; Interleukin-17 -- Immunology ; Proto-Oncogene Proteins -- Immunology ; Th17 Cells -- Immunology
descriptionEpigenetic modifications, such as posttranslational modifications of histones, play an important role in gene expression and regulation. These modifications are in part mediated by the Trithorax group (TrxG) complex and the Polycomb group (PcG) complex, which activate and repress transcription, respectively. We herein investigate the role of Menin, a component of the TrxG complex in T helper (Th) cell differentiation and show a critical role for Menin in differentiation and maintenance of Th17 cells. Menin(-/-) T cells do not efficiently differentiate into Th17 cells, leaving Th1 and Th2 cell differentiation intact in in vitro cultures. Menin deficiency resulted in the attenuation of Th17-induced airway inflammation. In differentiating Th17 cells, Menin directly bound to the Il17a gene locus and was required for the deposition of permissive histone modifications and recruitment of the RNA polymerase II transcriptional complex. Interestingly, although Menin bound to the Rorc locus, Menin...
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titleTrithorax complex component Menin controls differentiation and maintenance of T helper 17 cells
descriptionEpigenetic modifications, such as posttranslational modifications of histones, play an important role in gene expression and regulation. These modifications are in part mediated by the Trithorax group (TrxG) complex and the Polycomb group (PcG) complex, which activate and repress transcription, respectively. We herein investigate the role of Menin, a component of the TrxG complex in T helper (Th) cell differentiation and show a critical role for Menin in differentiation and maintenance of Th17 cells. Menin(-/-) T cells do not efficiently differentiate into Th17 cells, leaving Th1 and Th2 cell differentiation intact in in vitro cultures. Menin deficiency resulted in the attenuation of Th17-induced airway inflammation. In differentiating Th17 cells, Menin directly bound to the Il17a gene locus and was required for the deposition of permissive histone modifications and recruitment of the RNA polymerase II transcriptional complex. Interestingly, although Menin bound to the Rorc locus, Menin...
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titleTrithorax complex component Menin controls differentiation and maintenance of T helper 17 cells
authorWatanabe, Yukiko ; Onodera, Atsushi ; Kanai, Urara ; Ichikawa, Tomomi ; Obata-Ninomiya, Kazushige ; Wada, Tomoko ; Kiuchi, Masahiro ; Iwamura, Chiaki ; Tumes, Damon J ; Shinoda, Kenta ; Yagi, Ryoji ; Motohashi, Shinichiro ; Hirahara, Kiyoshi ; Nakayama, Toshinori
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atitleTrithorax complex component Menin controls differentiation and maintenance of T helper 17 cells
jtitleProceedings of the National Academy of Sciences of the United States of America
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abstractEpigenetic modifications, such as posttranslational modifications of histones, play an important role in gene expression and regulation. These modifications are in part mediated by the Trithorax group (TrxG) complex and the Polycomb group (PcG) complex, which activate and repress transcription, respectively. We herein investigate the role of Menin, a component of the TrxG complex in T helper (Th) cell differentiation and show a critical role for Menin in differentiation and maintenance of Th17 cells. Menin(-/-) T cells do not efficiently differentiate into Th17 cells, leaving Th1 and Th2 cell differentiation intact in in vitro cultures. Menin deficiency resulted in the attenuation of Th17-induced airway inflammation. In differentiating Th17 cells, Menin directly bound to the Il17a gene locus and was required for the deposition of permissive histone modifications and recruitment of the RNA polymerase II transcriptional complex. Interestingly, although Menin bound to the Rorc locus, Menin...
doi10.1073/pnas.1321245111
pmid25136117
date2014-09-02