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Morphologic changes in the anterior and posterior subregions of V1 and V2 and the V5/MT+ in patients with primary open-angle glaucoma

The aim of this study was to investigate possible morphologic changes of the visual cortex in primary open-angle glaucoma (POAG) with varying severity. Twenty normal controls (NC), 19 mild (MP) and 17 severe (SP) POAG patients were recruited and scanned using magnetic resonance imaging. Multi-parame... Full description

Journal Title: Brain research 07 November 2014, Vol.1588, pp.135-43
Main Author: Yu, Longhua
Other Authors: Yin, Xuntao , Dai, Chao , Liang, Minglong , Wei, Luqing , Li, Chuanming , Zhang, Jiuquan , Xie, Bing , Wang, Jian
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1872-6240 ; PMID: 25199592 Version:1 ; DOI: 10.1016/j.brainres.2014.09.005
Link: http://pubmed.gov/25199592
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recordid: medline25199592
title: Morphologic changes in the anterior and posterior subregions of V1 and V2 and the V5/MT+ in patients with primary open-angle glaucoma
format: Article
creator:
  • Yu, Longhua
  • Yin, Xuntao
  • Dai, Chao
  • Liang, Minglong
  • Wei, Luqing
  • Li, Chuanming
  • Zhang, Jiuquan
  • Xie, Bing
  • Wang, Jian
subjects:
  • Cortical Thickness
  • Primary Open-Angle Glaucoma
  • Retinal Nerve Fiber Layer
  • Shape Analysis
  • Visual Cortex
  • Visual Field
  • Volume
  • Glaucoma, Open-Angle -- Pathology
  • Visual Cortex -- Pathology
ispartof: Brain research, 07 November 2014, Vol.1588, pp.135-43
description: The aim of this study was to investigate possible morphologic changes of the visual cortex in primary open-angle glaucoma (POAG) with varying severity. Twenty normal controls (NC), 19 mild (MP) and 17 severe (SP) POAG patients were recruited and scanned using magnetic resonance imaging. Multi-parameter morphologic analyses with regions of interest (V5/MT+, anterior and posterior subregions of V1 and V2) were used to assess the cortical changes among the three groups. Compared with the NC group, decreased cortical thickness was detected in the V5/MT+ area in the MP group and in all of the investigated visual areas except the posterior subregion of V1 in the SP group. Unexpectedly, cortical thinning of the posterior subregion of V2 was detected in the SP group compared with the NC and MP groups. For the other morphologic parameters, only gray matter volume in the posterior subregion of V2 and mean curvature in the V5/MT+ were significantly changed in the SP group. In addition, the clinical...
language: eng
source:
identifier: E-ISSN: 1872-6240 ; PMID: 25199592 Version:1 ; DOI: 10.1016/j.brainres.2014.09.005
fulltext: fulltext
issn:
  • 18726240
  • 1872-6240
url: Link


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titleMorphologic changes in the anterior and posterior subregions of V1 and V2 and the V5/MT+ in patients with primary open-angle glaucoma
creatorYu, Longhua ; Yin, Xuntao ; Dai, Chao ; Liang, Minglong ; Wei, Luqing ; Li, Chuanming ; Zhang, Jiuquan ; Xie, Bing ; Wang, Jian
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subjectCortical Thickness ; Primary Open-Angle Glaucoma ; Retinal Nerve Fiber Layer ; Shape Analysis ; Visual Cortex ; Visual Field ; Volume ; Glaucoma, Open-Angle -- Pathology ; Visual Cortex -- Pathology
descriptionThe aim of this study was to investigate possible morphologic changes of the visual cortex in primary open-angle glaucoma (POAG) with varying severity. Twenty normal controls (NC), 19 mild (MP) and 17 severe (SP) POAG patients were recruited and scanned using magnetic resonance imaging. Multi-parameter morphologic analyses with regions of interest (V5/MT+, anterior and posterior subregions of V1 and V2) were used to assess the cortical changes among the three groups. Compared with the NC group, decreased cortical thickness was detected in the V5/MT+ area in the MP group and in all of the investigated visual areas except the posterior subregion of V1 in the SP group. Unexpectedly, cortical thinning of the posterior subregion of V2 was detected in the SP group compared with the NC and MP groups. For the other morphologic parameters, only gray matter volume in the posterior subregion of V2 and mean curvature in the V5/MT+ were significantly changed in the SP group. In addition, the clinical...
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titleMorphologic changes in the anterior and posterior subregions of V1 and V2 and the V5/MT+ in patients with primary open-angle glaucoma
descriptionThe aim of this study was to investigate possible morphologic changes of the visual cortex in primary open-angle glaucoma (POAG) with varying severity. Twenty normal controls (NC), 19 mild (MP) and 17 severe (SP) POAG patients were recruited and scanned using magnetic resonance imaging. Multi-parameter morphologic analyses with regions of interest (V5/MT+, anterior and posterior subregions of V1 and V2) were used to assess the cortical changes among the three groups. Compared with the NC group, decreased cortical thickness was detected in the V5/MT+ area in the MP group and in all of the investigated visual areas except the posterior subregion of V1 in the SP group. Unexpectedly, cortical thinning of the posterior subregion of V2 was detected in the SP group compared with the NC and MP groups. For the other morphologic parameters, only gray matter volume in the posterior subregion of V2 and mean curvature in the V5/MT+ were significantly changed in the SP group. In addition, the clinical...
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abstractThe aim of this study was to investigate possible morphologic changes of the visual cortex in primary open-angle glaucoma (POAG) with varying severity. Twenty normal controls (NC), 19 mild (MP) and 17 severe (SP) POAG patients were recruited and scanned using magnetic resonance imaging. Multi-parameter morphologic analyses with regions of interest (V5/MT+, anterior and posterior subregions of V1 and V2) were used to assess the cortical changes among the three groups. Compared with the NC group, decreased cortical thickness was detected in the V5/MT+ area in the MP group and in all of the investigated visual areas except the posterior subregion of V1 in the SP group. Unexpectedly, cortical thinning of the posterior subregion of V2 was detected in the SP group compared with the NC and MP groups. For the other morphologic parameters, only gray matter volume in the posterior subregion of V2 and mean curvature in the V5/MT+ were significantly changed in the SP group. In addition, the clinical...
doi10.1016/j.brainres.2014.09.005
pmid25199592
date2014-11-07