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A robust method for iodine status determination in epidemiological studies by capillary electrophoresis

Iodine deficiency is the most common preventable cause of intellectual disabilities in children. Global health initiatives to ensure optimum nutrition thus require continuous monitoring of population-wide iodine intake as determined by urinary excretion of iodide. Current methods to analyze urinary... Full description

Journal Title: Analytical chemistry 21 October 2014, Vol.86(20), pp.10010-5
Main Author: De Macedo, Adriana Nori
Other Authors: Teo, Koon , Mente, Andrew , Mcqueen, Matthew J , Zeidler, Johannes , Poirier, Paul , Lear, Scott A , Wielgosz, Andy , Britz-Mckibbin, Philip
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1520-6882 ; PMID: 25280130 Version:1 ; DOI: 10.1021/ac503231u
Link: http://pubmed.gov/25280130
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recordid: medline25280130
title: A robust method for iodine status determination in epidemiological studies by capillary electrophoresis
format: Article
creator:
  • De Macedo, Adriana Nori
  • Teo, Koon
  • Mente, Andrew
  • Mcqueen, Matthew J
  • Zeidler, Johannes
  • Poirier, Paul
  • Lear, Scott A
  • Wielgosz, Andy
  • Britz-Mckibbin, Philip
subjects:
  • Electrophoresis, Capillary -- Methods
  • Iodine -- Urine
ispartof: Analytical chemistry, 21 October 2014, Vol.86(20), pp.10010-5
description: Iodine deficiency is the most common preventable cause of intellectual disabilities in children. Global health initiatives to ensure optimum nutrition thus require continuous monitoring of population-wide iodine intake as determined by urinary excretion of iodide. Current methods to analyze urinary iodide are limited by complicated sample pretreatment, costly infrastructure, and/or poor selectivity, posing restrictions to large-scale epidemiological studies. We describe a simple yet selective method to analyze iodide in volume-restricted human urine specimens stored in biorepositories by capillary electrophoresis (CE) with UV detection. Excellent selectivity is achieved when using an acidic background electrolyte in conjunction with dynamic complexation via α-cyclodextrin in an unmodified fused-silica capillary under reversed polarity. Sample self-stacking is developed as a novel online sample preconcentration method to boost sensitivity with submicromolar detection limits for iodide (S/N...
language: eng
source:
identifier: E-ISSN: 1520-6882 ; PMID: 25280130 Version:1 ; DOI: 10.1021/ac503231u
fulltext: fulltext
issn:
  • 15206882
  • 1520-6882
url: Link


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titleA robust method for iodine status determination in epidemiological studies by capillary electrophoresis
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descriptionIodine deficiency is the most common preventable cause of intellectual disabilities in children. Global health initiatives to ensure optimum nutrition thus require continuous monitoring of population-wide iodine intake as determined by urinary excretion of iodide. Current methods to analyze urinary iodide are limited by complicated sample pretreatment, costly infrastructure, and/or poor selectivity, posing restrictions to large-scale epidemiological studies. We describe a simple yet selective method to analyze iodide in volume-restricted human urine specimens stored in biorepositories by capillary electrophoresis (CE) with UV detection. Excellent selectivity is achieved when using an acidic background electrolyte in conjunction with dynamic complexation via α-cyclodextrin in an unmodified fused-silica capillary under reversed polarity. Sample self-stacking is developed as a novel online sample preconcentration method to boost sensitivity with submicromolar detection limits for iodide (S/N...
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titleA robust method for iodine status determination in epidemiological studies by capillary electrophoresis
descriptionIodine deficiency is the most common preventable cause of intellectual disabilities in children. Global health initiatives to ensure optimum nutrition thus require continuous monitoring of population-wide iodine intake as determined by urinary excretion of iodide. Current methods to analyze urinary iodide are limited by complicated sample pretreatment, costly infrastructure, and/or poor selectivity, posing restrictions to large-scale epidemiological studies. We describe a simple yet selective method to analyze iodide in volume-restricted human urine specimens stored in biorepositories by capillary electrophoresis (CE) with UV detection. Excellent selectivity is achieved when using an acidic background electrolyte in conjunction with dynamic complexation via α-cyclodextrin in an unmodified fused-silica capillary under reversed polarity. Sample self-stacking is developed as a novel online sample preconcentration method to boost sensitivity with submicromolar detection limits for iodide (S/N...
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abstractIodine deficiency is the most common preventable cause of intellectual disabilities in children. Global health initiatives to ensure optimum nutrition thus require continuous monitoring of population-wide iodine intake as determined by urinary excretion of iodide. Current methods to analyze urinary iodide are limited by complicated sample pretreatment, costly infrastructure, and/or poor selectivity, posing restrictions to large-scale epidemiological studies. We describe a simple yet selective method to analyze iodide in volume-restricted human urine specimens stored in biorepositories by capillary electrophoresis (CE) with UV detection. Excellent selectivity is achieved when using an acidic background electrolyte in conjunction with dynamic complexation via α-cyclodextrin in an unmodified fused-silica capillary under reversed polarity. Sample self-stacking is developed as a novel online sample preconcentration method to boost sensitivity with submicromolar detection limits for iodide (S/N...
doi10.1021/ac503231u
pmid25280130
date2014-10-21