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Synthesis, spectral characterization and enzyme inhibition studies of different chlorinated sulfonamides

Sulfonamides are adherent to a biologically dynamic category of compounds and are under consideration of many organic synthetic researches to synthesize pharmacologically important compounds. In this demonstrated research work, a benignant series of chlorinated sulfonamides were synthesized and scre... Full description

Journal Title: Pakistan journal of pharmaceutical sciences November 2014, Vol.27(6), pp.1739-45
Main Author: Rehman, Aziz-Ur
Other Authors: Abbasi, Muhammad Athar , Rasool, Shahid , Ashraf, Muhammad , Ejaz, Syeda Abida , Hassan, Rabia , Khalid, Noreen
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 1011-601X ; PMID: 25362587 Version:1
Link: http://pubmed.gov/25362587
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recordid: medline25362587
title: Synthesis, spectral characterization and enzyme inhibition studies of different chlorinated sulfonamides
format: Article
creator:
  • Rehman, Aziz-Ur
  • Abbasi, Muhammad Athar
  • Rasool, Shahid
  • Ashraf, Muhammad
  • Ejaz, Syeda Abida
  • Hassan, Rabia
  • Khalid, Noreen
subjects:
  • Cholinesterase Inhibitors -- Chemical Synthesis
  • Sulfonamides -- Chemical Synthesis
ispartof: Pakistan journal of pharmaceutical sciences, November 2014, Vol.27(6), pp.1739-45
description: Sulfonamides are adherent to a biologically dynamic category of compounds and are under consideration of many organic synthetic researches to synthesize pharmacologically important compounds. In this demonstrated research work, a benignant series of chlorinated sulfonamides were synthesized and screened against different enzymes. These various chlorinated sulfonamides (3a-i) were set up by pairing of different substituted anilines (2a-i) with 4-chlorobenzenesulfonyl chloride (1) under basic pH in an aqueous media. The structures of the synthesized chlorinated sulfonamides were furnished by 1H-NMR, IR & EI-MS. The different enzymes used for the evaluation of bioactivity of all the synthesized compounds were urease, butyrylcholinesterase (BChE) and lipoxygenase (LOX). All the compounds exhibited good inhibitory activities against these enzymes but the strong activity was shown against BChE and hence can be employed for discovery of 'lead' compounds against Alzheimer's disease (AD).
language: eng
source:
identifier: ISSN: 1011-601X ; PMID: 25362587 Version:1
fulltext: fulltext
issn:
  • 1011601X
  • 1011-601X
url: Link


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titleSynthesis, spectral characterization and enzyme inhibition studies of different chlorinated sulfonamides
creatorRehman, Aziz-Ur ; Abbasi, Muhammad Athar ; Rasool, Shahid ; Ashraf, Muhammad ; Ejaz, Syeda Abida ; Hassan, Rabia ; Khalid, Noreen
ispartofPakistan journal of pharmaceutical sciences, November 2014, Vol.27(6), pp.1739-45
identifierISSN: 1011-601X ; PMID: 25362587 Version:1
subjectCholinesterase Inhibitors -- Chemical Synthesis ; Sulfonamides -- Chemical Synthesis
descriptionSulfonamides are adherent to a biologically dynamic category of compounds and are under consideration of many organic synthetic researches to synthesize pharmacologically important compounds. In this demonstrated research work, a benignant series of chlorinated sulfonamides were synthesized and screened against different enzymes. These various chlorinated sulfonamides (3a-i) were set up by pairing of different substituted anilines (2a-i) with 4-chlorobenzenesulfonyl chloride (1) under basic pH in an aqueous media. The structures of the synthesized chlorinated sulfonamides were furnished by 1H-NMR, IR & EI-MS. The different enzymes used for the evaluation of bioactivity of all the synthesized compounds were urease, butyrylcholinesterase (BChE) and lipoxygenase (LOX). All the compounds exhibited good inhibitory activities against these enzymes but the strong activity was shown against BChE and hence can be employed for discovery of 'lead' compounds against Alzheimer's disease (AD).
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titleSynthesis, spectral characterization and enzyme inhibition studies of different chlorinated sulfonamides
descriptionSulfonamides are adherent to a biologically dynamic category of compounds and are under consideration of many organic synthetic researches to synthesize pharmacologically important compounds. In this demonstrated research work, a benignant series of chlorinated sulfonamides were synthesized and screened against different enzymes. These various chlorinated sulfonamides (3a-i) were set up by pairing of different substituted anilines (2a-i) with 4-chlorobenzenesulfonyl chloride (1) under basic pH in an aqueous media. The structures of the synthesized chlorinated sulfonamides were furnished by 1H-NMR, IR & EI-MS. The different enzymes used for the evaluation of bioactivity of all the synthesized compounds were urease, butyrylcholinesterase (BChE) and lipoxygenase (LOX). All the compounds exhibited good inhibitory activities against these enzymes but the strong activity was shown against BChE and hence can be employed for discovery of 'lead' compounds against Alzheimer's disease (AD).
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titleSynthesis, spectral characterization and enzyme inhibition studies of different chlorinated sulfonamides
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abstractSulfonamides are adherent to a biologically dynamic category of compounds and are under consideration of many organic synthetic researches to synthesize pharmacologically important compounds. In this demonstrated research work, a benignant series of chlorinated sulfonamides were synthesized and screened against different enzymes. These various chlorinated sulfonamides (3a-i) were set up by pairing of different substituted anilines (2a-i) with 4-chlorobenzenesulfonyl chloride (1) under basic pH in an aqueous media. The structures of the synthesized chlorinated sulfonamides were furnished by 1H-NMR, IR & EI-MS. The different enzymes used for the evaluation of bioactivity of all the synthesized compounds were urease, butyrylcholinesterase (BChE) and lipoxygenase (LOX). All the compounds exhibited good inhibitory activities against these enzymes but the strong activity was shown against BChE and hence can be employed for discovery of 'lead' compounds against Alzheimer's disease (AD).
pmid25362587
date2014-11-01