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Association of circadian genes with diurnal blood pressure changes and non-dipper essential hypertension: a genetic association with young-onset hypertension

Recent studies have suggested that circadian genes have important roles in maintaining the circadian rhythm of the cardiovascular system. However, the associations between diurnal BP changes and circadian genes remain undetermined. We conducted a genetic association study of young-onset hypertension... Full description

Journal Title: Hypertension research : official journal of the Japanese Society of Hypertension February 2015, Vol.38(2), pp.155-62
Main Author: Leu, Hsin-Bang
Other Authors: Chung, Chia-Min , Lin, Shing-Jong , Chiang, Kuang-Mao , Yang, Hsin-Chou , Ho, Hung-Yun , Ting, Chih-Tai , Lin, Tsung-Hsien , Sheu, Sheng-Hsiung , Tsai, Wei-Chuan , Chen, Jyh-Hong , Yin, Wei-Hsian , Chiu, Ting-Yu , Chen, Chin-Iuan , Fann, Cathy Sj , Chen, Yuan-Tsong , Pan, Wen-Harn , Chen, Jaw-Wen
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1348-4214 ; PMID: 25410879 Version:1 ; DOI: 10.1038/hr.2014.152
Link: http://pubmed.gov/25410879
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recordid: medline25410879
title: Association of circadian genes with diurnal blood pressure changes and non-dipper essential hypertension: a genetic association with young-onset hypertension
format: Article
creator:
  • Leu, Hsin-Bang
  • Chung, Chia-Min
  • Lin, Shing-Jong
  • Chiang, Kuang-Mao
  • Yang, Hsin-Chou
  • Ho, Hung-Yun
  • Ting, Chih-Tai
  • Lin, Tsung-Hsien
  • Sheu, Sheng-Hsiung
  • Tsai, Wei-Chuan
  • Chen, Jyh-Hong
  • Yin, Wei-Hsian
  • Chiu, Ting-Yu
  • Chen, Chin-Iuan
  • Fann, Cathy Sj
  • Chen, Yuan-Tsong
  • Pan, Wen-Harn
  • Chen, Jaw-Wen
subjects:
  • Blood Pressure -- Genetics
  • Circadian Rhythm -- Genetics
  • Circadian Rhythm Signaling Peptides and Proteins -- Genetics
  • Hypertension -- Genetics
ispartof: Hypertension research : official journal of the Japanese Society of Hypertension, February 2015, Vol.38(2), pp.155-62
description: Recent studies have suggested that circadian genes have important roles in maintaining the circadian rhythm of the cardiovascular system. However, the associations between diurnal BP changes and circadian genes remain undetermined. We conducted a genetic association study of young-onset hypertension, in which 24-h ambulatory blood pressure (BP) monitoring was performed. A total of 23 tag single-nucleotide polymorphisms (SNPs) on 11 genes involved in circadian rhythms were genotyped for correlations with diurnal BP variation phenotypes. A permutation test was used to correct for multiple testing. Five tag SNPs within five loci, including rs3888170 in NPAS2, rs6431590 in PER2, rs1410225 in RORββ, rs3816358 in BMAL1 and rs10519096 in RORα, were significantly associated with the non-dipper phenotype in 372 young hypertensive patients. A genetic risk score was generated by counting the risk alleles and effects for each individual. Genotyping was performed in an additional independent set of 619 young-onset hypertensive subjects. Altogether, non-dippers had a higher weighted genetic risk score than dippers (1.67±0.56 vs. 1.54±0.55, P
language: eng
source:
identifier: E-ISSN: 1348-4214 ; PMID: 25410879 Version:1 ; DOI: 10.1038/hr.2014.152
fulltext: no_fulltext
issn:
  • 13484214
  • 1348-4214
url: Link


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titleAssociation of circadian genes with diurnal blood pressure changes and non-dipper essential hypertension: a genetic association with young-onset hypertension
creatorLeu, Hsin-Bang ; Chung, Chia-Min ; Lin, Shing-Jong ; Chiang, Kuang-Mao ; Yang, Hsin-Chou ; Ho, Hung-Yun ; Ting, Chih-Tai ; Lin, Tsung-Hsien ; Sheu, Sheng-Hsiung ; Tsai, Wei-Chuan ; Chen, Jyh-Hong ; Yin, Wei-Hsian ; Chiu, Ting-Yu ; Chen, Chin-Iuan ; Fann, Cathy Sj ; Chen, Yuan-Tsong ; Pan, Wen-Harn ; Chen, Jaw-Wen
ispartofHypertension research : official journal of the Japanese Society of Hypertension, February 2015, Vol.38(2), pp.155-62
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subjectBlood Pressure -- Genetics ; Circadian Rhythm -- Genetics ; Circadian Rhythm Signaling Peptides and Proteins -- Genetics ; Hypertension -- Genetics
descriptionRecent studies have suggested that circadian genes have important roles in maintaining the circadian rhythm of the cardiovascular system. However, the associations between diurnal BP changes and circadian genes remain undetermined. We conducted a genetic association study of young-onset hypertension, in which 24-h ambulatory blood pressure (BP) monitoring was performed. A total of 23 tag single-nucleotide polymorphisms (SNPs) on 11 genes involved in circadian rhythms were genotyped for correlations with diurnal BP variation phenotypes. A permutation test was used to correct for multiple testing. Five tag SNPs within five loci, including rs3888170 in NPAS2, rs6431590 in PER2, rs1410225 in RORββ, rs3816358 in BMAL1 and rs10519096 in RORα, were significantly associated with the non-dipper phenotype in 372 young hypertensive patients. A genetic risk score was generated by counting the risk alleles and effects for each individual. Genotyping was performed in an additional independent set of 619 young-onset hypertensive subjects. Altogether, non-dippers had a higher weighted genetic risk score than dippers (1.67±0.56 vs. 1.54±0.55, P<0.001), and the additive genetic risk score also indicated a graded association with decreased diurnal BP changes (P=0.006), as well as a non-dipper phenotype (P=0.031). After multivariable logistic analysis, only the circadian genetic risk score (odds ratio (OR), 1550; 95% confidence interval (CI), 1.225-1.961, P<0.001) and the use of β-blockers (OR, 1.519; 95% CI, 1.164-1.982, P=0.003) were independently associated with the presence of non-dippers among subjects with young-onset hypertension. Genetic variants in circadian genes were associated with the diurnal phenotype of hypertension, suggesting a genetic association with diurnal BP changes in essential hypertension.
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titleAssociation of circadian genes with diurnal blood pressure changes and non-dipper essential hypertension: a genetic association with young-onset hypertension
descriptionRecent studies have suggested that circadian genes have important roles in maintaining the circadian rhythm of the cardiovascular system. However, the associations between diurnal BP changes and circadian genes remain undetermined. We conducted a genetic association study of young-onset hypertension, in which 24-h ambulatory blood pressure (BP) monitoring was performed. A total of 23 tag single-nucleotide polymorphisms (SNPs) on 11 genes involved in circadian rhythms were genotyped for correlations with diurnal BP variation phenotypes. A permutation test was used to correct for multiple testing. Five tag SNPs within five loci, including rs3888170 in NPAS2, rs6431590 in PER2, rs1410225 in RORββ, rs3816358 in BMAL1 and rs10519096 in RORα, were significantly associated with the non-dipper phenotype in 372 young hypertensive patients. A genetic risk score was generated by counting the risk alleles and effects for each individual. Genotyping was performed in an additional independent set of 619 young-onset hypertensive subjects. Altogether, non-dippers had a higher weighted genetic risk score than dippers (1.67±0.56 vs. 1.54±0.55, P<0.001), and the additive genetic risk score also indicated a graded association with decreased diurnal BP changes (P=0.006), as well as a non-dipper phenotype (P=0.031). After multivariable logistic analysis, only the circadian genetic risk score (odds ratio (OR), 1550; 95% confidence interval (CI), 1.225-1.961, P<0.001) and the use of β-blockers (OR, 1.519; 95% CI, 1.164-1.982, P=0.003) were independently associated with the presence of non-dippers among subjects with young-onset hypertension. Genetic variants in circadian genes were associated with the diurnal phenotype of hypertension, suggesting a genetic association with diurnal BP changes in essential hypertension.
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titleAssociation of circadian genes with diurnal blood pressure changes and non-dipper essential hypertension: a genetic association with young-onset hypertension
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abstractRecent studies have suggested that circadian genes have important roles in maintaining the circadian rhythm of the cardiovascular system. However, the associations between diurnal BP changes and circadian genes remain undetermined. We conducted a genetic association study of young-onset hypertension, in which 24-h ambulatory blood pressure (BP) monitoring was performed. A total of 23 tag single-nucleotide polymorphisms (SNPs) on 11 genes involved in circadian rhythms were genotyped for correlations with diurnal BP variation phenotypes. A permutation test was used to correct for multiple testing. Five tag SNPs within five loci, including rs3888170 in NPAS2, rs6431590 in PER2, rs1410225 in RORββ, rs3816358 in BMAL1 and rs10519096 in RORα, were significantly associated with the non-dipper phenotype in 372 young hypertensive patients. A genetic risk score was generated by counting the risk alleles and effects for each individual. Genotyping was performed in an additional independent set of 619 young-onset hypertensive subjects. Altogether, non-dippers had a higher weighted genetic risk score than dippers (1.67±0.56 vs. 1.54±0.55, P<0.001), and the additive genetic risk score also indicated a graded association with decreased diurnal BP changes (P=0.006), as well as a non-dipper phenotype (P=0.031). After multivariable logistic analysis, only the circadian genetic risk score (odds ratio (OR), 1550; 95% confidence interval (CI), 1.225-1.961, P<0.001) and the use of β-blockers (OR, 1.519; 95% CI, 1.164-1.982, P=0.003) were independently associated with the presence of non-dippers among subjects with young-onset hypertension. Genetic variants in circadian genes were associated with the diurnal phenotype of hypertension, suggesting a genetic association with diurnal BP changes in essential hypertension.
doi10.1038/hr.2014.152
pmid25410879
issn09169636
oafree_for_read
date2015-02