schliessen

Filtern

 

Bibliotheken

Molecular pathways: aspirin and Wnt signaling-a molecularly targeted approach to cancer prevention and treatment

The anti-inflammatory properties of aspirin have resulted in its widespread use as an analgesic, antipyretic, and cardioprotective agent. Beyond these applications, multiple observational studies and randomized controlled trials have demonstrated a chemopreventative role for aspirin, particularly in... Full description

Journal Title: Clinical cancer research : an official journal of the American Association for Cancer Research 01 April 2015, Vol.21(7), pp.1543-8
Main Author: Gala, Manish K
Other Authors: Chan, Andrew T
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 1078-0432 ; PMID: 25501125 Version:1 ; DOI: 10.1158/1078-0432.CCR-14-0877
Link: http://pubmed.gov/25501125
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: medline25501125
title: Molecular pathways: aspirin and Wnt signaling-a molecularly targeted approach to cancer prevention and treatment
format: Article
creator:
  • Gala, Manish K
  • Chan, Andrew T
subjects:
  • Anti-Inflammatory Agents, Non-Steroidal -- Pharmacology
  • Aspirin -- Pharmacology
  • Colorectal Neoplasms -- Prevention & Control
  • Molecular Targeted Therapy -- Methods
  • Neoplasms -- Prevention & Control
  • Wnt Signaling Pathway -- Drug Effects
ispartof: Clinical cancer research : an official journal of the American Association for Cancer Research, 01 April 2015, Vol.21(7), pp.1543-8
description: The anti-inflammatory properties of aspirin have resulted in its widespread use as an analgesic, antipyretic, and cardioprotective agent. Beyond these applications, multiple observational studies and randomized controlled trials have demonstrated a chemopreventative role for aspirin, particularly in the development of colorectal neoplasia. Given the critical importance of Wnt dysregulation in colorectal carcinogenesis, the interplay between aspirin and canonical Wnt signaling has become a focus of investigation. These studies have illuminated our understanding of the anticancer mechanisms of aspirin, yielding the identification of potential biomarkers for which aspirin's chemopreventative efficacy can be safely optimized into routine clinical practice and providing leads into the discovery of novel preventive and therapeutic targets. In this review, we summarize key experimental and clinical studies of this interaction, as well as highlighting future strategies to advance their clinical...
language: eng
source:
identifier: ISSN: 1078-0432 ; PMID: 25501125 Version:1 ; DOI: 10.1158/1078-0432.CCR-14-0877
fulltext: fulltext
issn:
  • 10780432
  • 1078-0432
url: Link


@attributes
ID1531518730
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordid25501125
sourceidmedline
recordidTN_medline25501125
sourceformatXML
sourcesystemPC
pqid1669831573
display
typearticle
titleMolecular pathways: aspirin and Wnt signaling-a molecularly targeted approach to cancer prevention and treatment
creatorGala, Manish K ; Chan, Andrew T
ispartofClinical cancer research : an official journal of the American Association for Cancer Research, 01 April 2015, Vol.21(7), pp.1543-8
identifier
subjectAnti-Inflammatory Agents, Non-Steroidal -- Pharmacology ; Aspirin -- Pharmacology ; Colorectal Neoplasms -- Prevention & Control ; Molecular Targeted Therapy -- Methods ; Neoplasms -- Prevention & Control ; Wnt Signaling Pathway -- Drug Effects
descriptionThe anti-inflammatory properties of aspirin have resulted in its widespread use as an analgesic, antipyretic, and cardioprotective agent. Beyond these applications, multiple observational studies and randomized controlled trials have demonstrated a chemopreventative role for aspirin, particularly in the development of colorectal neoplasia. Given the critical importance of Wnt dysregulation in colorectal carcinogenesis, the interplay between aspirin and canonical Wnt signaling has become a focus of investigation. These studies have illuminated our understanding of the anticancer mechanisms of aspirin, yielding the identification of potential biomarkers for which aspirin's chemopreventative efficacy can be safely optimized into routine clinical practice and providing leads into the discovery of novel preventive and therapeutic targets. In this review, we summarize key experimental and clinical studies of this interaction, as well as highlighting future strategies to advance their clinical...
languageeng
source
version3
lds50peer_reviewed
links
openurl$$Topenurl_article
backlink$$Uhttp://pubmed.gov/25501125$$EView_this_record_in_MEDLINE/PubMed
openurlfulltext$$Topenurlfull_article
addlink$$Uhttp://exlibris-pub.s3.amazonaws.com/aboutMedline.html$$EView_the_MEDLINE/PubMed_Copyright_Statement
search
creatorcontrib
0Gala, Manish K
1Chan, Andrew T
titleMolecular pathways: aspirin and Wnt signaling-a molecularly targeted approach to cancer prevention and treatment
descriptionThe anti-inflammatory properties of aspirin have resulted in its widespread use as an analgesic, antipyretic, and cardioprotective agent. Beyond these applications, multiple observational studies and randomized controlled trials have demonstrated a chemopreventative role for aspirin, particularly in the development of colorectal neoplasia. Given the critical importance of Wnt dysregulation in colorectal carcinogenesis, the interplay between aspirin and canonical Wnt signaling has become a focus of investigation. These studies have illuminated our understanding of the anticancer mechanisms of aspirin, yielding the identification of potential biomarkers for which aspirin's chemopreventative efficacy can be safely optimized into routine clinical practice and providing leads into the discovery of novel preventive and therapeutic targets. In this review, we summarize key experimental and clinical studies of this interaction, as well as highlighting future strategies to advance their clinical...
subject
0Anti-Inflammatory Agents, Non-Steroidal -- Pharmacology
1Aspirin -- Pharmacology
2Colorectal Neoplasms -- Prevention & Control
3Molecular Targeted Therapy -- Methods
4Neoplasms -- Prevention & Control
5Wnt Signaling Pathway -- Drug Effects
general
025501125
1English
2MEDLINE/PubMed (U.S. National Library of Medicine)
310.1158/1078-0432.CCR-14-0877
4MEDLINE/PubMed (NLM)
sourceidmedline
recordidmedline25501125
issn
010780432
11078-0432
rsrctypearticle
creationdate2015
addtitleClinical cancer research : an official journal of the American Association for Cancer Research
searchscope
0medline
1nlm_medline
2MEDLINE
scope
0medline
1nlm_medline
2MEDLINE
lsr4120150401
citationpf 1543 vol 21 issue 7
startdate20150401
enddate20150401
lsr30VSR-Enriched:[pages, pqid, eissn]
sort
titleMolecular pathways: aspirin and Wnt signaling-a molecularly targeted approach to cancer prevention and treatment
authorGala, Manish K ; Chan, Andrew T
creationdate20150401
lso0120150401
facets
frbrgroupid7460909107110425801
frbrtype5
newrecords20190701
languageeng
creationdate2015
topic
0Anti-Inflammatory Agents, Non-Steroidal–Pharmacology
1Aspirin–Pharmacology
2Colorectal Neoplasms–Prevention & Control
3Molecular Targeted Therapy–Methods
4Neoplasms–Prevention & Control
5Wnt Signaling Pathway–Drug Effects
collectionMEDLINE/PubMed (NLM)
prefilterarticles
rsrctypearticles
creatorcontrib
0Gala, Manish K
1Chan, Andrew T
jtitleClinical Cancer Research : An Official Journal Of The American Association For Cancer Research
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
aulast
0Gala
1Chan
aufirst
0Manish K
1Andrew T
au
0Gala, Manish K
1Chan, Andrew T
atitleMolecular pathways: aspirin and Wnt signaling-a molecularly targeted approach to cancer prevention and treatment
jtitleClinical cancer research : an official journal of the American Association for Cancer Research
risdate20150401
volume21
issue7
spage1543
pages1543-1548
issn1078-0432
formatjournal
genrearticle
ristypeJOUR
abstractThe anti-inflammatory properties of aspirin have resulted in its widespread use as an analgesic, antipyretic, and cardioprotective agent. Beyond these applications, multiple observational studies and randomized controlled trials have demonstrated a chemopreventative role for aspirin, particularly in the development of colorectal neoplasia. Given the critical importance of Wnt dysregulation in colorectal carcinogenesis, the interplay between aspirin and canonical Wnt signaling has become a focus of investigation. These studies have illuminated our understanding of the anticancer mechanisms of aspirin, yielding the identification of potential biomarkers for which aspirin's chemopreventative efficacy can be safely optimized into routine clinical practice and providing leads into the discovery of novel preventive and therapeutic targets. In this review, we summarize key experimental and clinical studies of this interaction, as well as highlighting future strategies to advance their clinical...
doi10.1158/1078-0432.CCR-14-0877
pmid25501125
eissn15573265
date2015-04-01