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Silencing of long noncoding RNA MALAT1 by miR-101 and miR-217 inhibits proliferation, migration, and invasion of esophageal squamous cell carcinoma cells

MALAT1, a highly conserved long noncoding RNA, is deregulated in several types of cancers. However, its role in esophageal squamous cell carcinoma (ESCC) and its posttranscriptional regulation remain poorly understood. In this study we provide first evidences that a posttranscriptional regulation me... Full description

Journal Title: The Journal of biological chemistry 13 February 2015, Vol.290(7), pp.3925-35
Main Author: Wang, Xinyu
Other Authors: Li, Meng , Wang, Zhiqiong , Han, Sichong , Tang, Xiaohu , Ge, Yunxia , Zhou, Liqing , Zhou, Changchun , Yuan, Qipeng , Yang, Ming
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1083-351X ; PMID: 25538231 Version:1 ; DOI: 10.1074/jbc.M114.596866
Link: http://pubmed.gov/25538231
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recordid: medline25538231
title: Silencing of long noncoding RNA MALAT1 by miR-101 and miR-217 inhibits proliferation, migration, and invasion of esophageal squamous cell carcinoma cells
format: Article
creator:
  • Wang, Xinyu
  • Li, Meng
  • Wang, Zhiqiong
  • Han, Sichong
  • Tang, Xiaohu
  • Ge, Yunxia
  • Zhou, Liqing
  • Zhou, Changchun
  • Yuan, Qipeng
  • Yang, Ming
subjects:
  • Cancer
  • Esophageal Squamous Cell Carcinoma
  • Gene Regulation
  • Long Noncoding RNA (Long Ncrna, Lncrna)
  • Malat1
  • Microrna (Mirna)
  • Oncogene
  • Mir-101
  • Mir-217
  • Cell Movement
  • Cell Proliferation
  • Gene Silencing
  • Esophageal Neoplasms -- Pathology
  • Micrornas -- Genetics
  • RNA, Long Noncoding -- Metabolism
ispartof: The Journal of biological chemistry, 13 February 2015, Vol.290(7), pp.3925-35
description: MALAT1, a highly conserved long noncoding RNA, is deregulated in several types of cancers. However, its role in esophageal squamous cell carcinoma (ESCC) and its posttranscriptional regulation remain poorly understood. In this study we provide first evidences that a posttranscriptional regulation mechanism of MALAT1 by miR-101 and miR-217 exists in ESCC cells. This posttranscriptional silencing of MALAT1 could significantly suppress the proliferation of ESCC cells through the arrest of G2/M cell cycle, which may be due to MALAT1-mediated up-regulation of p21 and p27 expression and the inhibition of B-MYB expression. Moreover, we also found the abilities of migration and invasion of ESCC cells were inhibited after overexpression of miR-101, miR-217, or MALAT1 siRNA. This might be attributed to the deregulation of downstream genes of MALAT1, such as MIA2, HNF4G, ROBO1, CCT4, and CTHRC1. A significant negative correlation exists between miR-101 or miR-217 and MALAT1 in 42 pairs of ESCC tissue samples and adjacent normal tissues. Mice xenograft data also support the tumor suppressor role of both miRNAs in ESCCs.
language: eng
source:
identifier: E-ISSN: 1083-351X ; PMID: 25538231 Version:1 ; DOI: 10.1074/jbc.M114.596866
fulltext: fulltext
issn:
  • 1083351X
  • 1083-351X
url: Link


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titleSilencing of long noncoding RNA MALAT1 by miR-101 and miR-217 inhibits proliferation, migration, and invasion of esophageal squamous cell carcinoma cells
creatorWang, Xinyu ; Li, Meng ; Wang, Zhiqiong ; Han, Sichong ; Tang, Xiaohu ; Ge, Yunxia ; Zhou, Liqing ; Zhou, Changchun ; Yuan, Qipeng ; Yang, Ming
ispartofThe Journal of biological chemistry, 13 February 2015, Vol.290(7), pp.3925-35
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subjectCancer ; Esophageal Squamous Cell Carcinoma ; Gene Regulation ; Long Noncoding RNA (Long Ncrna, Lncrna) ; Malat1 ; Microrna (Mirna) ; Oncogene ; Mir-101 ; Mir-217 ; Cell Movement ; Cell Proliferation ; Gene Silencing ; Esophageal Neoplasms -- Pathology ; Micrornas -- Genetics ; RNA, Long Noncoding -- Metabolism
descriptionMALAT1, a highly conserved long noncoding RNA, is deregulated in several types of cancers. However, its role in esophageal squamous cell carcinoma (ESCC) and its posttranscriptional regulation remain poorly understood. In this study we provide first evidences that a posttranscriptional regulation mechanism of MALAT1 by miR-101 and miR-217 exists in ESCC cells. This posttranscriptional silencing of MALAT1 could significantly suppress the proliferation of ESCC cells through the arrest of G2/M cell cycle, which may be due to MALAT1-mediated up-regulation of p21 and p27 expression and the inhibition of B-MYB expression. Moreover, we also found the abilities of migration and invasion of ESCC cells were inhibited after overexpression of miR-101, miR-217, or MALAT1 siRNA. This might be attributed to the deregulation of downstream genes of MALAT1, such as MIA2, HNF4G, ROBO1, CCT4, and CTHRC1. A significant negative correlation exists between miR-101 or miR-217 and MALAT1 in 42 pairs of ESCC tissue samples and adjacent normal tissues. Mice xenograft data also support the tumor suppressor role of both miRNAs in ESCCs.
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titleSilencing of long noncoding RNA MALAT1 by miR-101 and miR-217 inhibits proliferation, migration, and invasion of esophageal squamous cell carcinoma cells
descriptionMALAT1, a highly conserved long noncoding RNA, is deregulated in several types of cancers. However, its role in esophageal squamous cell carcinoma (ESCC) and its posttranscriptional regulation remain poorly understood. In this study we provide first evidences that a posttranscriptional regulation mechanism of MALAT1 by miR-101 and miR-217 exists in ESCC cells. This posttranscriptional silencing of MALAT1 could significantly suppress the proliferation of ESCC cells through the arrest of G2/M cell cycle, which may be due to MALAT1-mediated up-regulation of p21 and p27 expression and the inhibition of B-MYB expression. Moreover, we also found the abilities of migration and invasion of ESCC cells were inhibited after overexpression of miR-101, miR-217, or MALAT1 siRNA. This might be attributed to the deregulation of downstream genes of MALAT1, such as MIA2, HNF4G, ROBO1, CCT4, and CTHRC1. A significant negative correlation exists between miR-101 or miR-217 and MALAT1 in 42 pairs of ESCC tissue samples and adjacent normal tissues. Mice xenograft data also support the tumor suppressor role of both miRNAs in ESCCs.
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titleSilencing of long noncoding RNA MALAT1 by miR-101 and miR-217 inhibits proliferation, migration, and invasion of esophageal squamous cell carcinoma cells
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atitleSilencing of long noncoding RNA MALAT1 by miR-101 and miR-217 inhibits proliferation, migration, and invasion of esophageal squamous cell carcinoma cells
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abstractMALAT1, a highly conserved long noncoding RNA, is deregulated in several types of cancers. However, its role in esophageal squamous cell carcinoma (ESCC) and its posttranscriptional regulation remain poorly understood. In this study we provide first evidences that a posttranscriptional regulation mechanism of MALAT1 by miR-101 and miR-217 exists in ESCC cells. This posttranscriptional silencing of MALAT1 could significantly suppress the proliferation of ESCC cells through the arrest of G2/M cell cycle, which may be due to MALAT1-mediated up-regulation of p21 and p27 expression and the inhibition of B-MYB expression. Moreover, we also found the abilities of migration and invasion of ESCC cells were inhibited after overexpression of miR-101, miR-217, or MALAT1 siRNA. This might be attributed to the deregulation of downstream genes of MALAT1, such as MIA2, HNF4G, ROBO1, CCT4, and CTHRC1. A significant negative correlation exists between miR-101 or miR-217 and MALAT1 in 42 pairs of ESCC tissue samples and adjacent normal tissues. Mice xenograft data also support the tumor suppressor role of both miRNAs in ESCCs.
doi10.1074/jbc.M114.596866
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date2015-02-13