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Application of molecular imaging technologies in antitumor drug development and therapy

Molecular imaging enables noninvasive characterization, quantification and visualization of biological and pathological processes in vivo at cellular and molecular level. It plays an important role in drug discovery and development. The skillful use of molecular imaging can provide unique insights i... Full description

Journal Title: Current pharmaceutical design 2015, Vol.21(16), pp.2136-46
Main Author: Lin, Yan
Other Authors: Chen, Zhi-Yi , Yang, Feng , Zhang, Jin-Shan , Wang, Yi-Xiang , Liu, Jin-Bing , Liao, Jian-Yi , Liao, Yang-Ying , Zhou, Qiu-Lan , Li, Bing-Cheng , Liang, Hui-Ying
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: MEDLINE/PubMed (U.S. National Library of Medicine)
ID: E-ISSN: 1873-4286 ; PMID: 25578891 Version:1
Link: http://pubmed.gov/25578891
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recordid: medline25578891
title: Application of molecular imaging technologies in antitumor drug development and therapy
format: Article
creator:
  • Lin, Yan
  • Chen, Zhi-Yi
  • Yang, Feng
  • Zhang, Jin-Shan
  • Wang, Yi-Xiang
  • Liu, Jin-Bing
  • Liao, Jian-Yi
  • Liao, Yang-Ying
  • Zhou, Qiu-Lan
  • Li, Bing-Cheng
  • Liang, Hui-Ying
subjects:
  • Antineoplastic Agents -- Chemical Synthesis
  • Drug Discovery -- Methods
  • Molecular Imaging -- Methods
  • Neoplasms -- Drug Therapy
ispartof: Current pharmaceutical design, 2015, Vol.21(16), pp.2136-46
description: Molecular imaging enables noninvasive characterization, quantification and visualization of biological and pathological processes in vivo at cellular and molecular level. It plays an important role in drug discovery and development. The skillful use of molecular imaging can provide unique insights into disease processes, which greatly aid in identifications of target. Importantly, molecular imaging is widely applied in the pharmacodynamics study to provide earlier endpoints during the preclinical drug development process, since it can be applied to monitor the effects of treatment in vivo with the use of biomarkers. Herein, we reviewed the application of molecular imaging technologies in antitumor drug development process ranging from identification of targets to evaluation of therapeutic effect.
language: eng
source: MEDLINE/PubMed (U.S. National Library of Medicine)
identifier: E-ISSN: 1873-4286 ; PMID: 25578891 Version:1
fulltext: fulltext
issn:
  • 18734286
  • 1873-4286
url: Link


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titleApplication of molecular imaging technologies in antitumor drug development and therapy
creatorLin, Yan ; Chen, Zhi-Yi ; Yang, Feng ; Zhang, Jin-Shan ; Wang, Yi-Xiang ; Liu, Jin-Bing ; Liao, Jian-Yi ; Liao, Yang-Ying ; Zhou, Qiu-Lan ; Li, Bing-Cheng ; Liang, Hui-Ying
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subjectAntineoplastic Agents -- Chemical Synthesis ; Drug Discovery -- Methods ; Molecular Imaging -- Methods ; Neoplasms -- Drug Therapy
descriptionMolecular imaging enables noninvasive characterization, quantification and visualization of biological and pathological processes in vivo at cellular and molecular level. It plays an important role in drug discovery and development. The skillful use of molecular imaging can provide unique insights into disease processes, which greatly aid in identifications of target. Importantly, molecular imaging is widely applied in the pharmacodynamics study to provide earlier endpoints during the preclinical drug development process, since it can be applied to monitor the effects of treatment in vivo with the use of biomarkers. Herein, we reviewed the application of molecular imaging technologies in antitumor drug development process ranging from identification of targets to evaluation of therapeutic effect.
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titleApplication of molecular imaging technologies in antitumor drug development and therapy
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abstractMolecular imaging enables noninvasive characterization, quantification and visualization of biological and pathological processes in vivo at cellular and molecular level. It plays an important role in drug discovery and development. The skillful use of molecular imaging can provide unique insights into disease processes, which greatly aid in identifications of target. Importantly, molecular imaging is widely applied in the pharmacodynamics study to provide earlier endpoints during the preclinical drug development process, since it can be applied to monitor the effects of treatment in vivo with the use of biomarkers. Herein, we reviewed the application of molecular imaging technologies in antitumor drug development process ranging from identification of targets to evaluation of therapeutic effect.
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