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Impact of valve surgery on serum osteopontin levels in patients with mitral regurgitation

Osteopontin (OPN), a sialoprotein present within atherosclerotic lesions, especially in calcified plaques, is linked to the progression of coronary artery disease and heart failure. We assessed the impact of valve surgery on serum OPN and left ventricular (LV) function in patients with mitral regurg... Full description

Journal Title: Cardiology 2015, Vol.130(2), pp.82-6
Main Author: Gunes, H M
Other Authors: Guler, G B , Guler, E , Demir, G G , Hatipoglu, S , Zehir, R , Kizilirmak, F , Karaca, O , Esen, A M , Barutcu, I , Turkmen, M M , Can, M M , Serebruany, Victor L
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1421-9751 ; PMID: 25592683 Version:1 ; DOI: 10.1159/000368299
Link: http://pubmed.gov/25592683
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recordid: medline25592683
title: Impact of valve surgery on serum osteopontin levels in patients with mitral regurgitation
format: Article
creator:
  • Gunes, H M
  • Guler, G B
  • Guler, E
  • Demir, G G
  • Hatipoglu, S
  • Zehir, R
  • Kizilirmak, F
  • Karaca, O
  • Esen, A M
  • Barutcu, I
  • Turkmen, M M
  • Can, M M
  • Serebruany, Victor L
subjects:
  • Mitral Valve Insufficiency -- Blood
  • Osteopontin -- Blood
ispartof: Cardiology, 2015, Vol.130(2), pp.82-6
description: Osteopontin (OPN), a sialoprotein present within atherosclerotic lesions, especially in calcified plaques, is linked to the progression of coronary artery disease and heart failure. We assessed the impact of valve surgery on serum OPN and left ventricular (LV) function in patients with mitral regurgitation (MR). Thirty-two patients with severe MR scheduled for surgery were included in the study. Echocardiography markers were assessed preoperatively and at 3 months following the surgery and matched with the serum OPN levels. Valve surgery was associated with a reduction of the ejection fraction (EF) from 55.2 ± 6.3 to 48.8 ± 7.1% after surgery, p < 0.001. Following surgery, the OPN level was significantly higher than preoperatively (mean 245, range 36-2,284 ng/ml vs. 76, 6-486 ng/ml, p = 0.007). Preoperative OPN exhibited a slight negative correlation with the EF (r = -0.35, p = 0.04), and a moderate correlation with vena contracta (r = -0.38, p = 0.02). There were no other meaningful correlations between conventional echocardiographic parameters and OPN. Following valve surgery due to severe MR, patients exhibited a decrease in EF and an increase in OPN levels. The assessment of preoperative OPN failed to strongly predict probable LV dysfunction.
language: eng
source:
identifier: E-ISSN: 1421-9751 ; PMID: 25592683 Version:1 ; DOI: 10.1159/000368299
fulltext: fulltext
issn:
  • 14219751
  • 1421-9751
url: Link


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titleImpact of valve surgery on serum osteopontin levels in patients with mitral regurgitation
creatorGunes, H M ; Guler, G B ; Guler, E ; Demir, G G ; Hatipoglu, S ; Zehir, R ; Kizilirmak, F ; Karaca, O ; Esen, A M ; Barutcu, I ; Turkmen, M M ; Can, M M ; Serebruany, Victor L
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subjectMitral Valve Insufficiency -- Blood ; Osteopontin -- Blood
descriptionOsteopontin (OPN), a sialoprotein present within atherosclerotic lesions, especially in calcified plaques, is linked to the progression of coronary artery disease and heart failure. We assessed the impact of valve surgery on serum OPN and left ventricular (LV) function in patients with mitral regurgitation (MR). Thirty-two patients with severe MR scheduled for surgery were included in the study. Echocardiography markers were assessed preoperatively and at 3 months following the surgery and matched with the serum OPN levels. Valve surgery was associated with a reduction of the ejection fraction (EF) from 55.2 ± 6.3 to 48.8 ± 7.1% after surgery, p < 0.001. Following surgery, the OPN level was significantly higher than preoperatively (mean 245, range 36-2,284 ng/ml vs. 76, 6-486 ng/ml, p = 0.007). Preoperative OPN exhibited a slight negative correlation with the EF (r = -0.35, p = 0.04), and a moderate correlation with vena contracta (r = -0.38, p = 0.02). There were no other meaningful correlations between conventional echocardiographic parameters and OPN. Following valve surgery due to severe MR, patients exhibited a decrease in EF and an increase in OPN levels. The assessment of preoperative OPN failed to strongly predict probable LV dysfunction.
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titleImpact of valve surgery on serum osteopontin levels in patients with mitral regurgitation
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0Osteopontin (OPN), a sialoprotein present within atherosclerotic lesions, especially in calcified plaques, is linked to the progression of coronary artery disease and heart failure. We assessed the impact of valve surgery on serum OPN and left ventricular (LV) function in patients with mitral regurgitation (MR).
1Thirty-two patients with severe MR scheduled for surgery were included in the study. Echocardiography markers were assessed preoperatively and at 3 months following the surgery and matched with the serum OPN levels.
2Valve surgery was associated with a reduction of the ejection fraction (EF) from 55.2 ± 6.3 to 48.8 ± 7.1% after surgery, p < 0.001. Following surgery, the OPN level was significantly higher than preoperatively (mean 245, range 36-2,284 ng/ml vs. 76, 6-486 ng/ml, p = 0.007). Preoperative OPN exhibited a slight negative correlation with the EF (r = -0.35, p = 0.04), and a moderate correlation with vena contracta (r = -0.38, p = 0.02). There were no other meaningful correlations between conventional echocardiographic parameters and OPN.
3Following valve surgery due to severe MR, patients exhibited a decrease in EF and an increase in OPN levels. The assessment of preoperative OPN failed to strongly predict probable LV dysfunction.
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atitleImpact of valve surgery on serum osteopontin levels in patients with mitral regurgitation
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abstractOsteopontin (OPN), a sialoprotein present within atherosclerotic lesions, especially in calcified plaques, is linked to the progression of coronary artery disease and heart failure. We assessed the impact of valve surgery on serum OPN and left ventricular (LV) function in patients with mitral regurgitation (MR).
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pmid25592683
issn00086312
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