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Evaluation of adiponectin and lipoprotein(a) levels in cardiac syndrome X

Low adiponectin and high lipoprotein(a) [Lp(a)] levels are associated with endothelial dysfunction, atherosclerosis, and coronary artery disease. Cardiac syndrome X (CSX) is characterized by anginal symptoms, positive stress test, and documentation of normal epicardial coronary arteries with angiogr... Full description

Journal Title: Herz May 2015, Vol.40 Suppl 3, pp.291-7
Main Author: Guler, E
Other Authors: Guler, G B , Kizilirmak, F , Batgerel, U , Demir, G G , Gunes, H M , Karaca, O , Özcan, Ö , Barutcu, I , Turkmen, M M , Esen, A M
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1615-6692 ; PMID: 25676008 Version:1 ; DOI: 10.1007/s00059-014-4191-1
Link: http://pubmed.gov/25676008
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recordid: medline25676008
title: Evaluation of adiponectin and lipoprotein(a) levels in cardiac syndrome X
format: Article
creator:
  • Guler, E
  • Guler, G B
  • Kizilirmak, F
  • Batgerel, U
  • Demir, G G
  • Gunes, H M
  • Karaca, O
  • Özcan, Ö
  • Barutcu, I
  • Turkmen, M M
  • Esen, A M
subjects:
  • Adiponectin -- Blood
  • Lipoprotein(a) -- Blood
  • Microvascular Angina -- Blood
ispartof: Herz, May 2015, Vol.40 Suppl 3, pp.291-7
description: Low adiponectin and high lipoprotein(a) [Lp(a)] levels are associated with endothelial dysfunction, atherosclerosis, and coronary artery disease. Cardiac syndrome X (CSX) is characterized by anginal symptoms, positive stress test, and documentation of normal epicardial coronary arteries with angiography. In this study we aimed to investigate the relationship between CSX and circulating levels of adiponectin and Lp(a). We enrolled 53 female patients with CSX and 33 patients as the control group. The diagnosis of CSX was made according to presence of angina, findings suggestive of ischemia during stress electrocardiography or myocardial perfusion scintigraphy, and documentation of normal coronary arteries in coronary angiography. The control group consisted of patients with atypical angina and normal stress electrocardiography test results. Both groups were matched in terms of hypertension, diabetes mellitus, and metabolic syndrome. Adiponectin levels were significantly decreased in patients with CSX (4.57 μg/ml vs. 13.18 μg/ml; p=0.001); however, Lp(a) levels were significantly increased (36.30 mg/dl vs. 7.24 mg/dl; p  21 mg/dl had 84 % sensitivity and 96 % specificity {area under the curve (AUC)= 0.922, p 
language: eng
source:
identifier: E-ISSN: 1615-6692 ; PMID: 25676008 Version:1 ; DOI: 10.1007/s00059-014-4191-1
fulltext: fulltext
issn:
  • 16156692
  • 1615-6692
url: Link


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titleEvaluation of adiponectin and lipoprotein(a) levels in cardiac syndrome X
creatorGuler, E ; Guler, G B ; Kizilirmak, F ; Batgerel, U ; Demir, G G ; Gunes, H M ; Karaca, O ; Özcan, Ö ; Barutcu, I ; Turkmen, M M ; Esen, A M
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subjectAdiponectin -- Blood ; Lipoprotein(a) -- Blood ; Microvascular Angina -- Blood
descriptionLow adiponectin and high lipoprotein(a) [Lp(a)] levels are associated with endothelial dysfunction, atherosclerosis, and coronary artery disease. Cardiac syndrome X (CSX) is characterized by anginal symptoms, positive stress test, and documentation of normal epicardial coronary arteries with angiography. In this study we aimed to investigate the relationship between CSX and circulating levels of adiponectin and Lp(a). We enrolled 53 female patients with CSX and 33 patients as the control group. The diagnosis of CSX was made according to presence of angina, findings suggestive of ischemia during stress electrocardiography or myocardial perfusion scintigraphy, and documentation of normal coronary arteries in coronary angiography. The control group consisted of patients with atypical angina and normal stress electrocardiography test results. Both groups were matched in terms of hypertension, diabetes mellitus, and metabolic syndrome. Adiponectin levels were significantly decreased in patients with CSX (4.57 μg/ml vs. 13.18 μg/ml; p=0.001); however, Lp(a) levels were significantly increased (36.30 mg/dl vs. 7.24 mg/dl; p  21 mg/dl had 84 % sensitivity and 96 % specificity {area under the curve (AUC)= 0.922, p < 0.0001, 95 % CI [0.842-0.970]} and an adiponectin level of ≤ 5.18 μg/ml also had 58.7 % sensitivity and 82.1 % specificity (AUC=0.726, p=0.0003, 95 % CI [0.609-0.823]) for detecting CSX. We detected low adiponectin and high Lp(a) levels in patients with CSX and these findings may be related to the microvascular injury in CSX.
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titleEvaluation of adiponectin and lipoprotein(a) levels in cardiac syndrome X
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0Low adiponectin and high lipoprotein(a) [Lp(a)] levels are associated with endothelial dysfunction, atherosclerosis, and coronary artery disease. Cardiac syndrome X (CSX) is characterized by anginal symptoms, positive stress test, and documentation of normal epicardial coronary arteries with angiography. In this study we aimed to investigate the relationship between CSX and circulating levels of adiponectin and Lp(a).
1We enrolled 53 female patients with CSX and 33 patients as the control group. The diagnosis of CSX was made according to presence of angina, findings suggestive of ischemia during stress electrocardiography or myocardial perfusion scintigraphy, and documentation of normal coronary arteries in coronary angiography. The control group consisted of patients with atypical angina and normal stress electrocardiography test results. Both groups were matched in terms of hypertension, diabetes mellitus, and metabolic syndrome.
2Adiponectin levels were significantly decreased in patients with CSX (4.57 μg/ml vs. 13.18 μg/ml; p=0.001); however, Lp(a) levels were significantly increased (36.30 mg/dl vs. 7.24 mg/dl; p  21 mg/dl had 84 % sensitivity and 96 % specificity {area under the curve (AUC)= 0.922, p < 0.0001, 95 % CI [0.842-0.970]} and an adiponectin level of ≤ 5.18 μg/ml also had 58.7 % sensitivity and 82.1 % specificity (AUC=0.726, p=0.0003, 95 % CI [0.609-0.823]) for detecting CSX.
3We detected low adiponectin and high Lp(a) levels in patients with CSX and these findings may be related to the microvascular injury in CSX.
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titleEvaluation of adiponectin and lipoprotein(a) levels in cardiac syndrome X
authorGuler, E ; Guler, G B ; Kizilirmak, F ; Batgerel, U ; Demir, G G ; Gunes, H M ; Karaca, O ; Özcan, Ö ; Barutcu, I ; Turkmen, M M ; Esen, A M
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atitleEvaluation of adiponectin and lipoprotein(a) levels in cardiac syndrome X
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abstractLow adiponectin and high lipoprotein(a) [Lp(a)] levels are associated with endothelial dysfunction, atherosclerosis, and coronary artery disease. Cardiac syndrome X (CSX) is characterized by anginal symptoms, positive stress test, and documentation of normal epicardial coronary arteries with angiography. In this study we aimed to investigate the relationship between CSX and circulating levels of adiponectin and Lp(a).
doi10.1007/s00059-014-4191-1
pmid25676008
issueS3
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date2015-05