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Diet-Induced Weight Loss Alters Functional Brain Responses during an Episodic Memory Task

It has been suggested that overweight is negatively associated with cognitive functions. The aim of this study was to investigate whether a reduction in body weight by dietary interventions could improve episodic memory performance and alter associated functional brain responses in overweight and ob... Full description

Journal Title: Obesity facts 2015, Vol.8(4), pp.261-72
Main Author: Boraxbekk, Carl-Johan
Other Authors: Stomby, Andreas , Ryberg, Mats , Lindahl, Bernt , Larsson, Christel , Nyberg, Lars , Olsson, Tommy
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1662-4033 ; PMID: 26139105 Version:1 ; DOI: 10.1159/000437157
Link: http://pubmed.gov/26139105
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recordid: medline26139105
title: Diet-Induced Weight Loss Alters Functional Brain Responses during an Episodic Memory Task
format: Article
creator:
  • Boraxbekk, Carl-Johan
  • Stomby, Andreas
  • Ryberg, Mats
  • Lindahl, Bernt
  • Larsson, Christel
  • Nyberg, Lars
  • Olsson, Tommy
subjects:
  • Brain Mapping
  • Diet, Paleolithic
  • Diet, Reducing
  • Memory, Episodic
  • Brain -- Physiopathology
  • Obesity -- Diet Therapy
  • Overweight -- Diet Therapy
  • Weight Loss -- Physiology
ispartof: Obesity facts, 2015, Vol.8(4), pp.261-72
description: It has been suggested that overweight is negatively associated with cognitive functions. The aim of this study was to investigate whether a reduction in body weight by dietary interventions could improve episodic memory performance and alter associated functional brain responses in overweight and obese women. 20 overweight postmenopausal women were randomized to either a modified paleolithic diet or a standard diet adhering to the Nordic Nutrition Recommendations for 6 months. We used functional magnetic resonance imaging to examine brain function during an episodic memory task as well as anthropometric and biochemical data before and after the interventions. Episodic memory performance improved significantly (p = 0.010) after the dietary interventions. Concomitantly, brain activity increased in the anterior part of the right hippocampus during memory encoding, without differences between diets. This was associated with decreased levels of plasma free fatty acids (FFA). Brain activity increased in pre-frontal cortex and superior/middle temporal gyri. The magnitude of increase correlated with waist circumference reduction. During episodic retrieval, brain activity decreased in inferior and middle frontal gyri, and increased in middle/superior temporal gyri. Diet-induced weight loss, associated with decreased levels of plasma FFA, improves episodic memory linked to increased hippocampal activity.
language: eng
source:
identifier: E-ISSN: 1662-4033 ; PMID: 26139105 Version:1 ; DOI: 10.1159/000437157
fulltext: fulltext
issn:
  • 16624033
  • 1662-4033
url: Link


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titleDiet-Induced Weight Loss Alters Functional Brain Responses during an Episodic Memory Task
creatorBoraxbekk, Carl-Johan ; Stomby, Andreas ; Ryberg, Mats ; Lindahl, Bernt ; Larsson, Christel ; Nyberg, Lars ; Olsson, Tommy
ispartofObesity facts, 2015, Vol.8(4), pp.261-72
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subjectBrain Mapping ; Diet, Paleolithic ; Diet, Reducing ; Memory, Episodic ; Brain -- Physiopathology ; Obesity -- Diet Therapy ; Overweight -- Diet Therapy ; Weight Loss -- Physiology
descriptionIt has been suggested that overweight is negatively associated with cognitive functions. The aim of this study was to investigate whether a reduction in body weight by dietary interventions could improve episodic memory performance and alter associated functional brain responses in overweight and obese women. 20 overweight postmenopausal women were randomized to either a modified paleolithic diet or a standard diet adhering to the Nordic Nutrition Recommendations for 6 months. We used functional magnetic resonance imaging to examine brain function during an episodic memory task as well as anthropometric and biochemical data before and after the interventions. Episodic memory performance improved significantly (p = 0.010) after the dietary interventions. Concomitantly, brain activity increased in the anterior part of the right hippocampus during memory encoding, without differences between diets. This was associated with decreased levels of plasma free fatty acids (FFA). Brain activity increased in pre-frontal cortex and superior/middle temporal gyri. The magnitude of increase correlated with waist circumference reduction. During episodic retrieval, brain activity decreased in inferior and middle frontal gyri, and increased in middle/superior temporal gyri. Diet-induced weight loss, associated with decreased levels of plasma FFA, improves episodic memory linked to increased hippocampal activity.
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120 overweight postmenopausal women were randomized to either a modified paleolithic diet or a standard diet adhering to the Nordic Nutrition Recommendations for 6 months. We used functional magnetic resonance imaging to examine brain function during an episodic memory task as well as anthropometric and biochemical data before and after the interventions.
2Episodic memory performance improved significantly (p = 0.010) after the dietary interventions. Concomitantly, brain activity increased in the anterior part of the right hippocampus during memory encoding, without differences between diets. This was associated with decreased levels of plasma free fatty acids (FFA). Brain activity increased in pre-frontal cortex and superior/middle temporal gyri. The magnitude of increase correlated with waist circumference reduction. During episodic retrieval, brain activity decreased in inferior and middle frontal gyri, and increased in middle/superior temporal gyri.
3Diet-induced weight loss, associated with decreased levels of plasma FFA, improves episodic memory linked to increased hippocampal activity.
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abstractIt has been suggested that overweight is negatively associated with cognitive functions. The aim of this study was to investigate whether a reduction in body weight by dietary interventions could improve episodic memory performance and alter associated functional brain responses in overweight and obese women.
doi10.1159/000437157
pmid26139105
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