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Elevated S100A9 expression in tumor stroma functions as an early recurrence marker for early-stage oral cancer patients through increased tumor cell invasion, angiogenesis, macrophage recruitment and interleukin-6 production

S100A9 is a calcium-binding protein with two EF-hands and frequently deregulated in several cancer types, however, with no clear role in oral cancer. In this report, the expression of S100A9 in cancer and adjacent tissues from 79 early-stage oral cancer patients was detected by immunohistochemical s... Full description

Journal Title: Oncotarget 29 September 2015, Vol.6(29), pp.28401-24
Main Author: Fang, Wei-Yu
Other Authors: Chen, Yi-Wen , Hsiao, Jenn-Ren , Liu, Chiang-Shin , Kuo, Yi-Zih , Wang, Yi-Ching , Chang, Kung-Chao , Tsai, Sen-Tien , Chang, Mei-Zhu , Lin, Siao-Han , Wu, Li-Wha
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1949-2553 ; PMID: 26315114 Version:1 ; DOI: 10.18632/oncotarget.4951
Link: http://pubmed.gov/26315114
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recordid: medline26315114
title: Elevated S100A9 expression in tumor stroma functions as an early recurrence marker for early-stage oral cancer patients through increased tumor cell invasion, angiogenesis, macrophage recruitment and interleukin-6 production
format: Article
creator:
  • Fang, Wei-Yu
  • Chen, Yi-Wen
  • Hsiao, Jenn-Ren
  • Liu, Chiang-Shin
  • Kuo, Yi-Zih
  • Wang, Yi-Ching
  • Chang, Kung-Chao
  • Tsai, Sen-Tien
  • Chang, Mei-Zhu
  • Lin, Siao-Han
  • Wu, Li-Wha
subjects:
  • Il-6
  • S100a9
  • Macrophages
  • Oral Cancer
  • Recurrence
  • Biomarkers, Tumor -- Biosynthesis
  • Calgranulin B -- Biosynthesis
  • Interleukin-6 -- Biosynthesis
  • Macrophages -- Metabolism
  • Mouth Neoplasms -- Metabolism
  • Neovascularization, Pathologic -- Metabolism
ispartof: Oncotarget, 29 September 2015, Vol.6(29), pp.28401-24
description: S100A9 is a calcium-binding protein with two EF-hands and frequently deregulated in several cancer types, however, with no clear role in oral cancer. In this report, the expression of S100A9 in cancer and adjacent tissues from 79 early-stage oral cancer patients was detected by immunohistochemical staining. Although S100A9 protein was present in both tumor and stromal cells, only the early-stage oral cancer patients with high stromal expression had reduced recurrence-free survival. High stromal S100A9 expression was also significantly associated with non-well differentiation and recurrence. In addition to increasing cell migration and invasion, ectopic S100A9 expression in tumor cells promoted xenograft tumorigenesis as well as the dominant expression of myeloid cell markers and pro-inflammatory IL-6. The expression of S100A9 in one stromal component, monocytes, stimulated the aggressiveness of co-cultured oral cancer cells. We also detected the elevation of serum S100A9 levels in early-stage...
language: eng
source:
identifier: E-ISSN: 1949-2553 ; PMID: 26315114 Version:1 ; DOI: 10.18632/oncotarget.4951
fulltext: fulltext
issn:
  • 19492553
  • 1949-2553
url: Link


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titleElevated S100A9 expression in tumor stroma functions as an early recurrence marker for early-stage oral cancer patients through increased tumor cell invasion, angiogenesis, macrophage recruitment and interleukin-6 production
creatorFang, Wei-Yu ; Chen, Yi-Wen ; Hsiao, Jenn-Ren ; Liu, Chiang-Shin ; Kuo, Yi-Zih ; Wang, Yi-Ching ; Chang, Kung-Chao ; Tsai, Sen-Tien ; Chang, Mei-Zhu ; Lin, Siao-Han ; Wu, Li-Wha
ispartofOncotarget, 29 September 2015, Vol.6(29), pp.28401-24
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subjectIl-6 ; S100a9 ; Macrophages ; Oral Cancer ; Recurrence ; Biomarkers, Tumor -- Biosynthesis ; Calgranulin B -- Biosynthesis ; Interleukin-6 -- Biosynthesis ; Macrophages -- Metabolism ; Mouth Neoplasms -- Metabolism ; Neovascularization, Pathologic -- Metabolism
descriptionS100A9 is a calcium-binding protein with two EF-hands and frequently deregulated in several cancer types, however, with no clear role in oral cancer. In this report, the expression of S100A9 in cancer and adjacent tissues from 79 early-stage oral cancer patients was detected by immunohistochemical staining. Although S100A9 protein was present in both tumor and stromal cells, only the early-stage oral cancer patients with high stromal expression had reduced recurrence-free survival. High stromal S100A9 expression was also significantly associated with non-well differentiation and recurrence. In addition to increasing cell migration and invasion, ectopic S100A9 expression in tumor cells promoted xenograft tumorigenesis as well as the dominant expression of myeloid cell markers and pro-inflammatory IL-6. The expression of S100A9 in one stromal component, monocytes, stimulated the aggressiveness of co-cultured oral cancer cells. We also detected the elevation of serum S100A9 levels in early-stage...
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descriptionS100A9 is a calcium-binding protein with two EF-hands and frequently deregulated in several cancer types, however, with no clear role in oral cancer. In this report, the expression of S100A9 in cancer and adjacent tissues from 79 early-stage oral cancer patients was detected by immunohistochemical staining. Although S100A9 protein was present in both tumor and stromal cells, only the early-stage oral cancer patients with high stromal expression had reduced recurrence-free survival. High stromal S100A9 expression was also significantly associated with non-well differentiation and recurrence. In addition to increasing cell migration and invasion, ectopic S100A9 expression in tumor cells promoted xenograft tumorigenesis as well as the dominant expression of myeloid cell markers and pro-inflammatory IL-6. The expression of S100A9 in one stromal component, monocytes, stimulated the aggressiveness of co-cultured oral cancer cells. We also detected the elevation of serum S100A9 levels in early-stage...
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abstractS100A9 is a calcium-binding protein with two EF-hands and frequently deregulated in several cancer types, however, with no clear role in oral cancer. In this report, the expression of S100A9 in cancer and adjacent tissues from 79 early-stage oral cancer patients was detected by immunohistochemical staining. Although S100A9 protein was present in both tumor and stromal cells, only the early-stage oral cancer patients with high stromal expression had reduced recurrence-free survival. High stromal S100A9 expression was also significantly associated with non-well differentiation and recurrence. In addition to increasing cell migration and invasion, ectopic S100A9 expression in tumor cells promoted xenograft tumorigenesis as well as the dominant expression of myeloid cell markers and pro-inflammatory IL-6. The expression of S100A9 in one stromal component, monocytes, stimulated the aggressiveness of co-cultured oral cancer cells. We also detected the elevation of serum S100A9 levels in early-stage...
doi10.18632/oncotarget.4951
pmid26315114
date2015-09-29