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Prognostic value of peripheral blood lymphocyte-to-monocyte ratio in patients with solid tumors: a meta-analysis

Although accumulating evidence suggests peripheral blood lymphocyte-to-monocyte ratio (LMR) could act as a prognosis predictor in various tumors, the prognostic value of LMR still remains controversial. We carried out this meta-analysis to evaluate the association of pretreatment LMR with survival o... Full description

Journal Title: OncoTargets and therapy 2016, Vol.9, pp.37-47
Main Author: Teng, Jun-Jie
Other Authors: Zhang, Jian , Zhang, Tian-Yi , Zhang, Shu , Li, Bao-Sheng
Format: Electronic Article Electronic Article
Language: English
Subjects:
Lmr
ID: ISSN: 1178-6930 ; PMID: 26730202 Version:1 ; DOI: 10.2147/OTT.S94458
Link: http://pubmed.gov/26730202
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recordid: medline26730202
title: Prognostic value of peripheral blood lymphocyte-to-monocyte ratio in patients with solid tumors: a meta-analysis
format: Article
creator:
  • Teng, Jun-Jie
  • Zhang, Jian
  • Zhang, Tian-Yi
  • Zhang, Shu
  • Li, Bao-Sheng
subjects:
  • Lmr
  • Meta-Analysis
  • Prognosis
  • Solid Tumors
ispartof: OncoTargets and therapy, 2016, Vol.9, pp.37-47
description: Although accumulating evidence suggests peripheral blood lymphocyte-to-monocyte ratio (LMR) could act as a prognosis predictor in various tumors, the prognostic value of LMR still remains controversial. We carried out this meta-analysis to evaluate the association of pretreatment LMR with survival outcomes in patients with solid tumors. Eligible studies were collected and extracted by searching PubMed and Embase databases up to June 3, 2015. The pooled hazard ratios (HRs) and their 95% confidence intervals (CIs) were computed to assess the prognostic value of LMR quantitatively. Eighteen studies with a total of 8,377 participants were enrolled in this meta-analysis. Our findings indicated that elevated pre-treatment LMR predicted a significantly favorable overall survival (HR=0.59, 95% CI: 0.53-0.67) and disease-free survival (HR=0.74, 95% CI: 0.68-0.80) in solid tumor patients. Subgroup analyses revealed that enhanced LMR was significantly associated with favorable overall survival in patients with digestive system cancers (HR=0.63, 95% CI: 0.49-0.81), urinary tract tumors (HR=0.66, 95% CI: 0.52-0.84), lung cancer (HR=0.62, 95% CI: 0.54-0.72), and nasopharyngeal carcinoma (HR=0.50, 95% CI: 0.43-0.57). This meta-analysis showed that enhanced LMR may indicate a favorable prognosis in patients with solid tumors.
language: eng
source:
identifier: ISSN: 1178-6930 ; PMID: 26730202 Version:1 ; DOI: 10.2147/OTT.S94458
fulltext: fulltext
issn:
  • 11786930
  • 1178-6930
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titlePrognostic value of peripheral blood lymphocyte-to-monocyte ratio in patients with solid tumors: a meta-analysis
creatorTeng, Jun-Jie ; Zhang, Jian ; Zhang, Tian-Yi ; Zhang, Shu ; Li, Bao-Sheng
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subjectLmr ; Meta-Analysis ; Prognosis ; Solid Tumors
descriptionAlthough accumulating evidence suggests peripheral blood lymphocyte-to-monocyte ratio (LMR) could act as a prognosis predictor in various tumors, the prognostic value of LMR still remains controversial. We carried out this meta-analysis to evaluate the association of pretreatment LMR with survival outcomes in patients with solid tumors. Eligible studies were collected and extracted by searching PubMed and Embase databases up to June 3, 2015. The pooled hazard ratios (HRs) and their 95% confidence intervals (CIs) were computed to assess the prognostic value of LMR quantitatively. Eighteen studies with a total of 8,377 participants were enrolled in this meta-analysis. Our findings indicated that elevated pre-treatment LMR predicted a significantly favorable overall survival (HR=0.59, 95% CI: 0.53-0.67) and disease-free survival (HR=0.74, 95% CI: 0.68-0.80) in solid tumor patients. Subgroup analyses revealed that enhanced LMR was significantly associated with favorable overall survival in patients with digestive system cancers (HR=0.63, 95% CI: 0.49-0.81), urinary tract tumors (HR=0.66, 95% CI: 0.52-0.84), lung cancer (HR=0.62, 95% CI: 0.54-0.72), and nasopharyngeal carcinoma (HR=0.50, 95% CI: 0.43-0.57). This meta-analysis showed that enhanced LMR may indicate a favorable prognosis in patients with solid tumors.
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0Although accumulating evidence suggests peripheral blood lymphocyte-to-monocyte ratio (LMR) could act as a prognosis predictor in various tumors, the prognostic value of LMR still remains controversial. We carried out this meta-analysis to evaluate the association of pretreatment LMR with survival outcomes in patients with solid tumors.
1Eligible studies were collected and extracted by searching PubMed and Embase databases up to June 3, 2015. The pooled hazard ratios (HRs) and their 95% confidence intervals (CIs) were computed to assess the prognostic value of LMR quantitatively.
2Eighteen studies with a total of 8,377 participants were enrolled in this meta-analysis. Our findings indicated that elevated pre-treatment LMR predicted a significantly favorable overall survival (HR=0.59, 95% CI: 0.53-0.67) and disease-free survival (HR=0.74, 95% CI: 0.68-0.80) in solid tumor patients. Subgroup analyses revealed that enhanced LMR was significantly associated with favorable overall survival in patients with digestive system cancers (HR=0.63, 95% CI: 0.49-0.81), urinary tract tumors (HR=0.66, 95% CI: 0.52-0.84), lung cancer (HR=0.62, 95% CI: 0.54-0.72), and nasopharyngeal carcinoma (HR=0.50, 95% CI: 0.43-0.57).
3This meta-analysis showed that enhanced LMR may indicate a favorable prognosis in patients with solid tumors.
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abstractAlthough accumulating evidence suggests peripheral blood lymphocyte-to-monocyte ratio (LMR) could act as a prognosis predictor in various tumors, the prognostic value of LMR still remains controversial. We carried out this meta-analysis to evaluate the association of pretreatment LMR with survival outcomes in patients with solid tumors.
doi10.2147/OTT.S94458
pmid26730202