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Urinary N-methylnicotinamide and β-aminoisobutyric acid predict catch-up growth in undernourished Brazilian children

Enteric infections, enteropathy and undernutrition in early childhood are preventable risk factors for child deaths, impaired neurodevelopment, and later life metabolic diseases. However, the mechanisms linking these exposures and outcomes remain to be elucidated, as do biomarkers for identifying ch... Full description

Journal Title: Scientific reports 27 January 2016, Vol.6, pp.19780
Main Author: Mayneris-Perxachs, Jordi
Other Authors: Lima, Aldo A M , Guerrant, Richard L , Leite, Álvaro M , Moura, Alessandra F , Lima, Noélia L , Soares, Alberto M , Havt, Alexandre , Moore, Sean R , Pinkerton, Relana , Swann, Jonathan R
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 2045-2322 ; PMID: 26816084 Version:1 ; DOI: 10.1038/srep19780
Link: http://pubmed.gov/26816084
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recordid: medline26816084
title: Urinary N-methylnicotinamide and β-aminoisobutyric acid predict catch-up growth in undernourished Brazilian children
format: Article
creator:
  • Mayneris-Perxachs, Jordi
  • Lima, Aldo A M
  • Guerrant, Richard L
  • Leite, Álvaro M
  • Moura, Alessandra F
  • Lima, Noélia L
  • Soares, Alberto M
  • Havt, Alexandre
  • Moore, Sean R
  • Pinkerton, Relana
  • Swann, Jonathan R
subjects:
  • Child Development
  • Infant Nutrition Disorders
  • Malnutrition
  • Aminoisobutyric Acids -- Urine
  • Niacinamide -- Analogs & Derivatives
ispartof: Scientific reports, 27 January 2016, Vol.6, pp.19780
description: Enteric infections, enteropathy and undernutrition in early childhood are preventable risk factors for child deaths, impaired neurodevelopment, and later life metabolic diseases. However, the mechanisms linking these exposures and outcomes remain to be elucidated, as do biomarkers for identifying children at risk. By examining the urinary metabolic phenotypes of nourished and undernourished children participating in a case-control study in Semi-Arid Brazil, we identified key differences with potential relevance to mechanisms, biomarkers and outcomes. Undernutrition was found to perturb several biochemical pathways, including choline and tryptophan metabolism, while also increasing the proteolytic activity of the gut microbiome. Furthermore, a metabolic adaptation was observed in the undernourished children to reduce energy expenditure, reflected by increased N-methylnicotinamide and reduced β-aminoisobutyric acid excretion. Interestingly, accelerated catch-up growth was observed in those undernourished children displaying a more robust metabolic adaptation several months earlier. Hence, urinary N-methylnicotinamide and β-aminoisobutyric acid represent promising biomarkers for predicting short-term growth outcomes in undernourished children and for identifying children destined for further growth shortfalls. These findings have important implications for understanding contributors to long-term sequelae of early undernutrition, including cognitive, growth, and metabolic functions.
language: eng
source:
identifier: E-ISSN: 2045-2322 ; PMID: 26816084 Version:1 ; DOI: 10.1038/srep19780
fulltext: fulltext
issn:
  • 20452322
  • 2045-2322
url: Link


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titleUrinary N-methylnicotinamide and β-aminoisobutyric acid predict catch-up growth in undernourished Brazilian children
creatorMayneris-Perxachs, Jordi ; Lima, Aldo A M ; Guerrant, Richard L ; Leite, Álvaro M ; Moura, Alessandra F ; Lima, Noélia L ; Soares, Alberto M ; Havt, Alexandre ; Moore, Sean R ; Pinkerton, Relana ; Swann, Jonathan R
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subjectChild Development ; Infant Nutrition Disorders ; Malnutrition ; Aminoisobutyric Acids -- Urine ; Niacinamide -- Analogs & Derivatives
descriptionEnteric infections, enteropathy and undernutrition in early childhood are preventable risk factors for child deaths, impaired neurodevelopment, and later life metabolic diseases. However, the mechanisms linking these exposures and outcomes remain to be elucidated, as do biomarkers for identifying children at risk. By examining the urinary metabolic phenotypes of nourished and undernourished children participating in a case-control study in Semi-Arid Brazil, we identified key differences with potential relevance to mechanisms, biomarkers and outcomes. Undernutrition was found to perturb several biochemical pathways, including choline and tryptophan metabolism, while also increasing the proteolytic activity of the gut microbiome. Furthermore, a metabolic adaptation was observed in the undernourished children to reduce energy expenditure, reflected by increased N-methylnicotinamide and reduced β-aminoisobutyric acid excretion. Interestingly, accelerated catch-up growth was observed in those undernourished children displaying a more robust metabolic adaptation several months earlier. Hence, urinary N-methylnicotinamide and β-aminoisobutyric acid represent promising biomarkers for predicting short-term growth outcomes in undernourished children and for identifying children destined for further growth shortfalls. These findings have important implications for understanding contributors to long-term sequelae of early undernutrition, including cognitive, growth, and metabolic functions.
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abstractEnteric infections, enteropathy and undernutrition in early childhood are preventable risk factors for child deaths, impaired neurodevelopment, and later life metabolic diseases. However, the mechanisms linking these exposures and outcomes remain to be elucidated, as do biomarkers for identifying children at risk. By examining the urinary metabolic phenotypes of nourished and undernourished children participating in a case-control study in Semi-Arid Brazil, we identified key differences with potential relevance to mechanisms, biomarkers and outcomes. Undernutrition was found to perturb several biochemical pathways, including choline and tryptophan metabolism, while also increasing the proteolytic activity of the gut microbiome. Furthermore, a metabolic adaptation was observed in the undernourished children to reduce energy expenditure, reflected by increased N-methylnicotinamide and reduced β-aminoisobutyric acid excretion. Interestingly, accelerated catch-up growth was observed in those undernourished children displaying a more robust metabolic adaptation several months earlier. Hence, urinary N-methylnicotinamide and β-aminoisobutyric acid represent promising biomarkers for predicting short-term growth outcomes in undernourished children and for identifying children destined for further growth shortfalls. These findings have important implications for understanding contributors to long-term sequelae of early undernutrition, including cognitive, growth, and metabolic functions.
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