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Making Sense of Epigenetics

The gene-environment interactions that underlie development and progression of psychiatric illness are poorly understood. Despite a century of progress, genetic approaches have failed to identify new treatment modalities, perhaps because of the heterogeneity of the disorders and lack of understandin... Full description

Journal Title: The international journal of neuropsychopharmacology November 2016, Vol.19(11)
Main Author: Schuebel, Kornel
Other Authors: Gitik, Miri , Domschke, Katharina , Goldman, David
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1469-5111 ; PMID: 27312741 Version:1 ; DOI: 10.1093/ijnp/pyw058
Link: http://pubmed.gov/27312741
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recordid: medline27312741
title: Making Sense of Epigenetics
format: Article
creator:
  • Schuebel, Kornel
  • Gitik, Miri
  • Domschke, Katharina
  • Goldman, David
subjects:
  • DNA Methylation
  • Chromatin
  • Epigenetics
  • Neuropsychiatric Disorders
  • DNA Methylation
  • Epigenesis, Genetic
  • Mental Disorders -- Genetics
ispartof: The international journal of neuropsychopharmacology, November 2016, Vol.19(11)
description: The gene-environment interactions that underlie development and progression of psychiatric illness are poorly understood. Despite a century of progress, genetic approaches have failed to identify new treatment modalities, perhaps because of the heterogeneity of the disorders and lack of understanding of mechanisms. Recent exploration into epigenetic mechanisms in health and disease has uncovered changes in DNA methylation and chromatin structure that may contribute to psychiatric disorders. Epigenetic changes suggest a variety of new therapeutic options due to their reversible chemistry. However, distinguishing causal links between epigenetic changes and disease from changes consequent to life experience has remained problematic. Here we define epigenetics and explore aspects of epigenetics relevant to causes and mechanisms of psychiatric disease, and speculate on future directions.
language: eng
source:
identifier: E-ISSN: 1469-5111 ; PMID: 27312741 Version:1 ; DOI: 10.1093/ijnp/pyw058
fulltext: fulltext
issn:
  • 14695111
  • 1469-5111
url: Link


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descriptionThe gene-environment interactions that underlie development and progression of psychiatric illness are poorly understood. Despite a century of progress, genetic approaches have failed to identify new treatment modalities, perhaps because of the heterogeneity of the disorders and lack of understanding of mechanisms. Recent exploration into epigenetic mechanisms in health and disease has uncovered changes in DNA methylation and chromatin structure that may contribute to psychiatric disorders. Epigenetic changes suggest a variety of new therapeutic options due to their reversible chemistry. However, distinguishing causal links between epigenetic changes and disease from changes consequent to life experience has remained problematic. Here we define epigenetics and explore aspects of epigenetics relevant to causes and mechanisms of psychiatric disease, and speculate on future directions.
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abstractThe gene-environment interactions that underlie development and progression of psychiatric illness are poorly understood. Despite a century of progress, genetic approaches have failed to identify new treatment modalities, perhaps because of the heterogeneity of the disorders and lack of understanding of mechanisms. Recent exploration into epigenetic mechanisms in health and disease has uncovered changes in DNA methylation and chromatin structure that may contribute to psychiatric disorders. Epigenetic changes suggest a variety of new therapeutic options due to their reversible chemistry. However, distinguishing causal links between epigenetic changes and disease from changes consequent to life experience has remained problematic. Here we define epigenetics and explore aspects of epigenetics relevant to causes and mechanisms of psychiatric disease, and speculate on future directions.
doi10.1093/ijnp/pyw058
pmid27312741
date2016-11