schliessen

Filtern

 

Bibliotheken

Plasma lipidomics reveals potential lipid markers of major depressive disorder

Major depressive disorder (MDD) is a grave debilitating mental disease with a high incidence and severely impairs quality of life. Therefore, its physiopathological basis study and diagnostic biomarker discovery are extremely valuable. In this study, a non-targeted lipidomics strategy using ultra pe... Full description

Journal Title: Analytical and bioanalytical chemistry September 2016, Vol.408(23), pp.6497-507
Main Author: Liu, Xinyu
Other Authors: Li, Jia , Zheng, Peng , Zhao, Xinjie , Zhou, Chanjuan , Hu, Chunxiu , Hou, Xiaoli , Wang, Haiyang , Xie, Peng , Xu, Guowang
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1618-2650 ; PMID: 27457104 Version:1 ; DOI: 10.1007/s00216-016-9768-5
Link: http://pubmed.gov/27457104
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: medline27457104
title: Plasma lipidomics reveals potential lipid markers of major depressive disorder
format: Article
creator:
  • Liu, Xinyu
  • Li, Jia
  • Zheng, Peng
  • Zhao, Xinjie
  • Zhou, Chanjuan
  • Hu, Chunxiu
  • Hou, Xiaoli
  • Wang, Haiyang
  • Xie, Peng
  • Xu, Guowang
subjects:
  • Diagnostic Biomarker
  • Major Depressive Disorder
  • Non-Targeted Lipidomics
  • Uplc-MS
  • Chromatography, High Pressure Liquid -- Methods
  • Depressive Disorder, Major -- Blood
  • Lipids -- Blood
  • Mass Spectrometry -- Methods
ispartof: Analytical and bioanalytical chemistry, September 2016, Vol.408(23), pp.6497-507
description: Major depressive disorder (MDD) is a grave debilitating mental disease with a high incidence and severely impairs quality of life. Therefore, its physiopathological basis study and diagnostic biomarker discovery are extremely valuable. In this study, a non-targeted lipidomics strategy using ultra performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MS) was performed to reveal differential lipids between MDD (n = 60) and healthy controls (HCs, n = 60). Validation of changed lipid species was performed in an independent batch including 75 MDD and 52 HC using the same lipidomic method. Pronouncedly changed lipid species in MDD were discovered, which mainly were lysophosphatidylcholine (LPC), lysophosphatidylethanolamine (LPE), phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylinositol (PI), 1-O-alkyl-2-acyl-PE (PE O), 1-O-alkyl-2-acyl-PC (PC O), sphingomyelin (SM), diacylglycerol (DG), and triacylglycerol (TG). Among these...
language: eng
source:
identifier: E-ISSN: 1618-2650 ; PMID: 27457104 Version:1 ; DOI: 10.1007/s00216-016-9768-5
fulltext: fulltext
issn:
  • 16182650
  • 1618-2650
url: Link


@attributes
ID1349392624
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordid27457104
sourceidmedline
recordidTN_medline27457104
sourceformatXML
sourcesystemPC
pqid1867932357
galeid470423860
display
typearticle
titlePlasma lipidomics reveals potential lipid markers of major depressive disorder
creatorLiu, Xinyu ; Li, Jia ; Zheng, Peng ; Zhao, Xinjie ; Zhou, Chanjuan ; Hu, Chunxiu ; Hou, Xiaoli ; Wang, Haiyang ; Xie, Peng ; Xu, Guowang
ispartofAnalytical and bioanalytical chemistry, September 2016, Vol.408(23), pp.6497-507
identifier
subjectDiagnostic Biomarker ; Major Depressive Disorder ; Non-Targeted Lipidomics ; Uplc-MS ; Chromatography, High Pressure Liquid -- Methods ; Depressive Disorder, Major -- Blood ; Lipids -- Blood ; Mass Spectrometry -- Methods
descriptionMajor depressive disorder (MDD) is a grave debilitating mental disease with a high incidence and severely impairs quality of life. Therefore, its physiopathological basis study and diagnostic biomarker discovery are extremely valuable. In this study, a non-targeted lipidomics strategy using ultra performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MS) was performed to reveal differential lipids between MDD (n = 60) and healthy controls (HCs, n = 60). Validation of changed lipid species was performed in an independent batch including 75 MDD and 52 HC using the same lipidomic method. Pronouncedly changed lipid species in MDD were discovered, which mainly were lysophosphatidylcholine (LPC), lysophosphatidylethanolamine (LPE), phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylinositol (PI), 1-O-alkyl-2-acyl-PE (PE O), 1-O-alkyl-2-acyl-PC (PC O), sphingomyelin (SM), diacylglycerol (DG), and triacylglycerol (TG). Among these...
languageeng
source
version6
lds50peer_reviewed
links
openurl$$Topenurl_article
backlink$$Uhttp://pubmed.gov/27457104$$EView_this_record_in_MEDLINE/PubMed
openurlfulltext$$Topenurlfull_article
addlink$$Uhttp://exlibris-pub.s3.amazonaws.com/aboutMedline.html$$EView_the_MEDLINE/PubMed_Copyright_Statement
search
creatorcontrib
0Liu, Xinyu
1Li, Jia
2Zheng, Peng
3Zhao, Xinjie
4Zhou, Chanjuan
5Hu, Chunxiu
6Hou, Xiaoli
7Wang, Haiyang
8Xie, Peng
9Xu, Guowang
titlePlasma lipidomics reveals potential lipid markers of major depressive disorder
descriptionMajor depressive disorder (MDD) is a grave debilitating mental disease with a high incidence and severely impairs quality of life. Therefore, its physiopathological basis study and diagnostic biomarker discovery are extremely valuable. In this study, a non-targeted lipidomics strategy using ultra performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MS) was performed to reveal differential lipids between MDD (n = 60) and healthy controls (HCs, n = 60). Validation of changed lipid species was performed in an independent batch including 75 MDD and 52 HC using the same lipidomic method. Pronouncedly changed lipid species in MDD were discovered, which mainly were lysophosphatidylcholine (LPC), lysophosphatidylethanolamine (LPE), phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylinositol (PI), 1-O-alkyl-2-acyl-PE (PE O), 1-O-alkyl-2-acyl-PC (PC O), sphingomyelin (SM), diacylglycerol (DG), and triacylglycerol (TG). Among these...
subject
0Diagnostic Biomarker
1Major Depressive Disorder
2Non-Targeted Lipidomics
3Uplc-MS
4Chromatography, High Pressure Liquid -- Methods
5Depressive Disorder, Major -- Blood
6Lipids -- Blood
7Mass Spectrometry -- Methods
general
027457104
1English
2MEDLINE/PubMed (U.S. National Library of Medicine)
310.1007/s00216-016-9768-5
4MEDLINE/PubMed (NLM)
sourceidmedline
recordidmedline27457104
issn
016182650
11618-2650
rsrctypearticle
creationdate2016
addtitleAnalytical and bioanalytical chemistry
searchscope
0medline
1nlm_medline
2MEDLINE
scope
0medline
1nlm_medline
2MEDLINE
lsr41201609
citationpf 6497 vol 408 issue 23
startdate20160901
enddate20160931
lsr30VSR-Enriched:[pages, galeid, pqid]
sort
titlePlasma lipidomics reveals potential lipid markers of major depressive disorder
authorLiu, Xinyu ; Li, Jia ; Zheng, Peng ; Zhao, Xinjie ; Zhou, Chanjuan ; Hu, Chunxiu ; Hou, Xiaoli ; Wang, Haiyang ; Xie, Peng ; Xu, Guowang
creationdate20160900
lso0120160900
facets
frbrgroupid6402540759923660348
frbrtype5
newrecords20190701
languageeng
creationdate2016
topic
0Diagnostic Biomarker
1Major Depressive Disorder
2Non-Targeted Lipidomics
3Uplc-MS
4Chromatography, High Pressure Liquid–Methods
5Depressive Disorder, Major–Blood
6Lipids–Blood
7Mass Spectrometry–Methods
collectionMEDLINE/PubMed (NLM)
prefilterarticles
rsrctypearticles
creatorcontrib
0Liu, Xinyu
1Li, Jia
2Zheng, Peng
3Zhao, Xinjie
4Zhou, Chanjuan
5Hu, Chunxiu
6Hou, Xiaoli
7Wang, Haiyang
8Xie, Peng
9Xu, Guowang
jtitleAnalytical And Bioanalytical Chemistry
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
aulast
0Liu
1Li
2Zheng
3Zhao
4Zhou
5Hu
6Hou
7Wang
8Xie
9Xu
aufirst
0Xinyu
1Jia
2Peng
3Xinjie
4Chanjuan
5Chunxiu
6Xiaoli
7Haiyang
8Guowang
au
0Liu, Xinyu
1Li, Jia
2Zheng, Peng
3Zhao, Xinjie
4Zhou, Chanjuan
5Hu, Chunxiu
6Hou, Xiaoli
7Wang, Haiyang
8Xie, Peng
9Xu, Guowang
atitlePlasma lipidomics reveals potential lipid markers of major depressive disorder
jtitleAnalytical and bioanalytical chemistry
risdate201609
volume408
issue23
spage6497
pages6497-6507
issn1618-2642
eissn1618-2650
formatjournal
genrearticle
ristypeJOUR
abstractMajor depressive disorder (MDD) is a grave debilitating mental disease with a high incidence and severely impairs quality of life. Therefore, its physiopathological basis study and diagnostic biomarker discovery are extremely valuable. In this study, a non-targeted lipidomics strategy using ultra performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MS) was performed to reveal differential lipids between MDD (n = 60) and healthy controls (HCs, n = 60). Validation of changed lipid species was performed in an independent batch including 75 MDD and 52 HC using the same lipidomic method. Pronouncedly changed lipid species in MDD were discovered, which mainly were lysophosphatidylcholine (LPC), lysophosphatidylethanolamine (LPE), phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylinositol (PI), 1-O-alkyl-2-acyl-PE (PE O), 1-O-alkyl-2-acyl-PC (PC O), sphingomyelin (SM), diacylglycerol (DG), and triacylglycerol (TG). Among these...
doi10.1007/s00216-016-9768-5
pmid27457104
date2016-09