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Two subtypes of colorectal tumor with distinct molecular features in familial adenomatous polyposis

While sporadic colorectal cancer (CRC) is classified into several molecular subtypes, stratification of familial colorectal tumors is yet to be well investigated. We previously established two groups of methylation markers through genome-wide DNA methylation analysis, which classified sporadic CRC a... Full description

Journal Title: Oncotarget 20 December 2016, Vol.7(51), pp.84003-84016
Main Author: Takane, Kiyoko
Other Authors: Matsusaka, Keisuke , Ota, Satoshi , Fukuyo, Masaki , Yue, Yao , Nishimura, Motoi , Sakai, Eiji , Matsushita, Kazuyuki , Miyauchi, Hideaki , Aburatani, Hiroyuki , Nakatani, Yukio , Takayama, Tadatoshi , Matsubara, Hisahiro , Akagi, Kiwamu , Kaneda, Atsushi
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1949-2553 ; PMID: 27563825 Version:1 ; DOI: 10.18632/oncotarget.11510
Link: http://pubmed.gov/27563825
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recordid: medline27563825
title: Two subtypes of colorectal tumor with distinct molecular features in familial adenomatous polyposis
format: Article
creator:
  • Takane, Kiyoko
  • Matsusaka, Keisuke
  • Ota, Satoshi
  • Fukuyo, Masaki
  • Yue, Yao
  • Nishimura, Motoi
  • Sakai, Eiji
  • Matsushita, Kazuyuki
  • Miyauchi, Hideaki
  • Aburatani, Hiroyuki
  • Nakatani, Yukio
  • Takayama, Tadatoshi
  • Matsubara, Hisahiro
  • Akagi, Kiwamu
  • Kaneda, Atsushi
subjects:
  • Cimp
  • DNA Methylation
  • Kras
  • Colorectal Cancer
  • Familial Adenomatous Polyposis (Fap)
  • DNA Methylation
  • Epigenesis, Genetic
  • Adenomatous Polyposis Coli -- Genetics
  • Biomarkers, Tumor -- Genetics
ispartof: Oncotarget, 20 December 2016, Vol.7(51), pp.84003-84016
description: While sporadic colorectal cancer (CRC) is classified into several molecular subtypes, stratification of familial colorectal tumors is yet to be well investigated. We previously established two groups of methylation markers through genome-wide DNA methylation analysis, which classified sporadic CRC and adenoma into three distinct subgroups: high-, intermediate-, and low-methylation epigenotypes. Here, we investigated familial adenomatous polyposis (FAP), through quantitative methylation analysis of 127 samples (16 cancers, 96 adenomas, and 15 benign mucosa from 14 patients with FAP) using six Group-1 and 14 Group-2 methylation markers, APC, BRAF, and KRAS mutation analysis, and CTNNB1 and TP53 immunohistochemical analysis. All the 14 patients presented with APC germline mutation. Three were from the same family and presented the same APC mutation. FAP tumors lacked BRAF-mutation(+) high-methylation epigenotype and were classified into two methylation epigenotypes. While 24 of 112 tumor samples...
language: eng
source:
identifier: E-ISSN: 1949-2553 ; PMID: 27563825 Version:1 ; DOI: 10.18632/oncotarget.11510
fulltext: fulltext
issn:
  • 19492553
  • 1949-2553
url: Link


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titleTwo subtypes of colorectal tumor with distinct molecular features in familial adenomatous polyposis
creatorTakane, Kiyoko ; Matsusaka, Keisuke ; Ota, Satoshi ; Fukuyo, Masaki ; Yue, Yao ; Nishimura, Motoi ; Sakai, Eiji ; Matsushita, Kazuyuki ; Miyauchi, Hideaki ; Aburatani, Hiroyuki ; Nakatani, Yukio ; Takayama, Tadatoshi ; Matsubara, Hisahiro ; Akagi, Kiwamu ; Kaneda, Atsushi
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subjectCimp ; DNA Methylation ; Kras ; Colorectal Cancer ; Familial Adenomatous Polyposis (Fap) ; DNA Methylation ; Epigenesis, Genetic ; Adenomatous Polyposis Coli -- Genetics ; Biomarkers, Tumor -- Genetics
descriptionWhile sporadic colorectal cancer (CRC) is classified into several molecular subtypes, stratification of familial colorectal tumors is yet to be well investigated. We previously established two groups of methylation markers through genome-wide DNA methylation analysis, which classified sporadic CRC and adenoma into three distinct subgroups: high-, intermediate-, and low-methylation epigenotypes. Here, we investigated familial adenomatous polyposis (FAP), through quantitative methylation analysis of 127 samples (16 cancers, 96 adenomas, and 15 benign mucosa from 14 patients with FAP) using six Group-1 and 14 Group-2 methylation markers, APC, BRAF, and KRAS mutation analysis, and CTNNB1 and TP53 immunohistochemical analysis. All the 14 patients presented with APC germline mutation. Three were from the same family and presented the same APC mutation. FAP tumors lacked BRAF-mutation(+) high-methylation epigenotype and were classified into two methylation epigenotypes. While 24 of 112 tumor samples...
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titleTwo subtypes of colorectal tumor with distinct molecular features in familial adenomatous polyposis
descriptionWhile sporadic colorectal cancer (CRC) is classified into several molecular subtypes, stratification of familial colorectal tumors is yet to be well investigated. We previously established two groups of methylation markers through genome-wide DNA methylation analysis, which classified sporadic CRC and adenoma into three distinct subgroups: high-, intermediate-, and low-methylation epigenotypes. Here, we investigated familial adenomatous polyposis (FAP), through quantitative methylation analysis of 127 samples (16 cancers, 96 adenomas, and 15 benign mucosa from 14 patients with FAP) using six Group-1 and 14 Group-2 methylation markers, APC, BRAF, and KRAS mutation analysis, and CTNNB1 and TP53 immunohistochemical analysis. All the 14 patients presented with APC germline mutation. Three were from the same family and presented the same APC mutation. FAP tumors lacked BRAF-mutation(+) high-methylation epigenotype and were classified into two methylation epigenotypes. While 24 of 112 tumor samples...
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abstractWhile sporadic colorectal cancer (CRC) is classified into several molecular subtypes, stratification of familial colorectal tumors is yet to be well investigated. We previously established two groups of methylation markers through genome-wide DNA methylation analysis, which classified sporadic CRC and adenoma into three distinct subgroups: high-, intermediate-, and low-methylation epigenotypes. Here, we investigated familial adenomatous polyposis (FAP), through quantitative methylation analysis of 127 samples (16 cancers, 96 adenomas, and 15 benign mucosa from 14 patients with FAP) using six Group-1 and 14 Group-2 methylation markers, APC, BRAF, and KRAS mutation analysis, and CTNNB1 and TP53 immunohistochemical analysis. All the 14 patients presented with APC germline mutation. Three were from the same family and presented the same APC mutation. FAP tumors lacked BRAF-mutation(+) high-methylation epigenotype and were classified into two methylation epigenotypes. While 24 of 112 tumor samples...
doi10.18632/oncotarget.11510
pmid27563825
date2016-12-20