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Porcine epidemic diarrhea virus nucleoprotein contributes to HMGB1 transcription and release by interacting with C/EBP-β

Porcine epidemic diarrhea is a devastating swine enteric disease, which is caused by porcine epidemic diarrhea virus (PEDV) infection. Our studies demonstrated that PEDV infection resulted in the up-regulation of proinflammatory cytokines. Meanwhile, PEDV infection and overexpression of viral nucleo... Full description

Journal Title: Oncotarget 15 November 2016, Vol.7(46), pp.75064-75080
Main Author: Huan, Chang-Chao
Other Authors: Wang, Hua-Xia , Sheng, Xiang-Xiang , Wang, Rui , Wang, Xin , Liao, Ying , Liu, Qin-Fang , Tong, Guang-Zhi , Ding, Chan , Fan, Hong-Jie , Wu, Jia-Qiang , Mao, Xiang
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1949-2553 ; PMID: 27634894 Version:1 ; DOI: 10.18632/oncotarget.11991
Link: http://pubmed.gov/27634894
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recordid: medline27634894
title: Porcine epidemic diarrhea virus nucleoprotein contributes to HMGB1 transcription and release by interacting with C/EBP-β
format: Article
creator:
  • Huan, Chang-Chao
  • Wang, Hua-Xia
  • Sheng, Xiang-Xiang
  • Wang, Rui
  • Wang, Xin
  • Liao, Ying
  • Liu, Qin-Fang
  • Tong, Guang-Zhi
  • Ding, Chan
  • Fan, Hong-Jie
  • Wu, Jia-Qiang
  • Mao, Xiang
subjects:
  • C/Ebp-Β
  • Hmgb1
  • Nucleoprotein
  • Porcine Epidemic Diarrhea Virus
  • Gene Expression Regulation
  • Transcription, Genetic
  • Ccaat-Enhancer-Binding Protein-Beta -- Metabolism
  • Hmgb1 Protein -- Genetics
  • Nucleoproteins -- Metabolism
  • Porcine Epidemic Diarrhea Virus -- Physiology
ispartof: Oncotarget, 15 November 2016, Vol.7(46), pp.75064-75080
description: Porcine epidemic diarrhea is a devastating swine enteric disease, which is caused by porcine epidemic diarrhea virus (PEDV) infection. Our studies demonstrated that PEDV infection resulted in the up-regulation of proinflammatory cytokines. Meanwhile, PEDV infection and overexpression of viral nucleoprotein resulted in the acetylation and release of high mobility group box 1 proteins in vitro, an important proinflammatory response mediator, which contributes to the pathogenesis of various inflammatory diseases. Our studies also showed that SIRT1, histone acetyltransferase, and NF-κB regulated the acetylation and release of HMGB1. Chromatin immunoprecipitation, dual-luciferase reporter gene assay, and co-immunoprecipitation experiments illustrated that PEDV-N could induce HMGB1 transcription by interacting with C/EBP-β, which could bind to C/EBP motif in HMGB1 promotor region. Collectively, our data indicate PEDV-N contributes to HMGB1 transcription and the subsequent release/acetylation...
language: eng
source:
identifier: E-ISSN: 1949-2553 ; PMID: 27634894 Version:1 ; DOI: 10.18632/oncotarget.11991
fulltext: fulltext
issn:
  • 19492553
  • 1949-2553
url: Link


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titlePorcine epidemic diarrhea virus nucleoprotein contributes to HMGB1 transcription and release by interacting with C/EBP-β
creatorHuan, Chang-Chao ; Wang, Hua-Xia ; Sheng, Xiang-Xiang ; Wang, Rui ; Wang, Xin ; Liao, Ying ; Liu, Qin-Fang ; Tong, Guang-Zhi ; Ding, Chan ; Fan, Hong-Jie ; Wu, Jia-Qiang ; Mao, Xiang
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subjectC/Ebp-Β ; Hmgb1 ; Nucleoprotein ; Porcine Epidemic Diarrhea Virus ; Gene Expression Regulation ; Transcription, Genetic ; Ccaat-Enhancer-Binding Protein-Beta -- Metabolism ; Hmgb1 Protein -- Genetics ; Nucleoproteins -- Metabolism ; Porcine Epidemic Diarrhea Virus -- Physiology
descriptionPorcine epidemic diarrhea is a devastating swine enteric disease, which is caused by porcine epidemic diarrhea virus (PEDV) infection. Our studies demonstrated that PEDV infection resulted in the up-regulation of proinflammatory cytokines. Meanwhile, PEDV infection and overexpression of viral nucleoprotein resulted in the acetylation and release of high mobility group box 1 proteins in vitro, an important proinflammatory response mediator, which contributes to the pathogenesis of various inflammatory diseases. Our studies also showed that SIRT1, histone acetyltransferase, and NF-κB regulated the acetylation and release of HMGB1. Chromatin immunoprecipitation, dual-luciferase reporter gene assay, and co-immunoprecipitation experiments illustrated that PEDV-N could induce HMGB1 transcription by interacting with C/EBP-β, which could bind to C/EBP motif in HMGB1 promotor region. Collectively, our data indicate PEDV-N contributes to HMGB1 transcription and the subsequent release/acetylation...
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abstractPorcine epidemic diarrhea is a devastating swine enteric disease, which is caused by porcine epidemic diarrhea virus (PEDV) infection. Our studies demonstrated that PEDV infection resulted in the up-regulation of proinflammatory cytokines. Meanwhile, PEDV infection and overexpression of viral nucleoprotein resulted in the acetylation and release of high mobility group box 1 proteins in vitro, an important proinflammatory response mediator, which contributes to the pathogenesis of various inflammatory diseases. Our studies also showed that SIRT1, histone acetyltransferase, and NF-κB regulated the acetylation and release of HMGB1. Chromatin immunoprecipitation, dual-luciferase reporter gene assay, and co-immunoprecipitation experiments illustrated that PEDV-N could induce HMGB1 transcription by interacting with C/EBP-β, which could bind to C/EBP motif in HMGB1 promotor region. Collectively, our data indicate PEDV-N contributes to HMGB1 transcription and the subsequent release/acetylation...
doi10.18632/oncotarget.11991
pmid27634894
date2016-11-15