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Silymarin Ameliorates Metabolic Dysfunction Associated with Diet-Induced Obesity via Activation of Farnesyl X Receptor

Silymarin, a standardized extract of the milk thistle seeds, has been widely used to treat chronic hepatitis, cirrhosis, and other types of toxic liver damage. Despite increasing studies on the action of silymarin and its major active constituent, silybin in their therapeutic properties against insu... Full description

Journal Title: Frontiers in pharmacology 2016, Vol.7, pp.345
Main Author: Gu, Ming
Other Authors: Zhao, Ping , Huang, Jinwen , Zhao, Yuanyuan , Wang, Yahui , Li, Yin , Li, Yifei , Fan, Shengjie , Ma, Yue-Ming , Tong, Qingchun , Yang, Li , Ji, Guang , Huang, Cheng
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: MEDLINE/PubMed (U.S. National Library of Medicine)
ID: ISSN: 1663-9812 ; PMID: 27733832 Version:1
Link: http://pubmed.gov/27733832
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title: Silymarin Ameliorates Metabolic Dysfunction Associated with Diet-Induced Obesity via Activation of Farnesyl X Receptor
format: Article
creator:
  • Gu, Ming
  • Zhao, Ping
  • Huang, Jinwen
  • Zhao, Yuanyuan
  • Wang, Yahui
  • Li, Yin
  • Li, Yifei
  • Fan, Shengjie
  • Ma, Yue-Ming
  • Tong, Qingchun
  • Yang, Li
  • Ji, Guang
  • Huang, Cheng
subjects:
  • Farnesyl X Receptor
  • Metabolic Syndrome
  • Non-Alcoholic Fatty Liver Disease
  • Silybin
  • Silymarin
ispartof: Frontiers in pharmacology, 2016, Vol.7, pp.345
description: Silymarin, a standardized extract of the milk thistle seeds, has been widely used to treat chronic hepatitis, cirrhosis, and other types of toxic liver damage. Despite increasing studies on the action of silymarin and its major active constituent, silybin in their therapeutic properties against insulin resistance, diabetes and hyperlipidaemia and , the mechanism underlying silymarin action remains unclear. C57BL/6 mice were fed high-fat diet (HFD) for 3 months to induce obesity, insulin resistance, hyperlipidaemia, and fatty liver. These mice were then continuously treated with HFD alone or mixed with silymarin at 40 mg/100 g for additional 6 weeks. Biochemical analysis was used to test the serum lipid and bile acid profiles. Farnesyl X receptor (FXR) and nuclear factor kappa B (NF-κB) transactivities were analyzed in liver using a gene reporter assay based on quantitative RT-PCR. Silymarin treatment ameliorated insulin resistance, dyslipidaemia and inflammation, and reconstituted the...
language: eng
source: MEDLINE/PubMed (U.S. National Library of Medicine)
identifier: ISSN: 1663-9812 ; PMID: 27733832 Version:1
fulltext: fulltext
issn:
  • 16639812
  • 1663-9812
url: Link


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titleSilymarin Ameliorates Metabolic Dysfunction Associated with Diet-Induced Obesity via Activation of Farnesyl X Receptor
creatorGu, Ming ; Zhao, Ping ; Huang, Jinwen ; Zhao, Yuanyuan ; Wang, Yahui ; Li, Yin ; Li, Yifei ; Fan, Shengjie ; Ma, Yue-Ming ; Tong, Qingchun ; Yang, Li ; Ji, Guang ; Huang, Cheng
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identifierISSN: 1663-9812 ; PMID: 27733832 Version:1
subjectFarnesyl X Receptor ; Metabolic Syndrome ; Non-Alcoholic Fatty Liver Disease ; Silybin ; Silymarin
descriptionSilymarin, a standardized extract of the milk thistle seeds, has been widely used to treat chronic hepatitis, cirrhosis, and other types of toxic liver damage. Despite increasing studies on the action of silymarin and its major active constituent, silybin in their therapeutic properties against insulin resistance, diabetes and hyperlipidaemia and , the mechanism underlying silymarin action remains unclear. C57BL/6 mice were fed high-fat diet (HFD) for 3 months to induce obesity, insulin resistance, hyperlipidaemia, and fatty liver. These mice were then continuously treated with HFD alone or mixed with silymarin at 40 mg/100 g for additional 6 weeks. Biochemical analysis was used to test the serum lipid and bile acid profiles. Farnesyl X receptor (FXR) and nuclear factor kappa B (NF-κB) transactivities were analyzed in liver using a gene reporter assay based on quantitative RT-PCR. Silymarin treatment ameliorated insulin resistance, dyslipidaemia and inflammation, and reconstituted the...
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descriptionSilymarin, a standardized extract of the milk thistle seeds, has been widely used to treat chronic hepatitis, cirrhosis, and other types of toxic liver damage. Despite increasing studies on the action of silymarin and its major active constituent, silybin in their therapeutic properties against insulin resistance, diabetes and hyperlipidaemia and , the mechanism underlying silymarin action remains unclear. C57BL/6 mice were fed high-fat diet (HFD) for 3 months to induce obesity, insulin resistance, hyperlipidaemia, and fatty liver. These mice were then continuously treated with HFD alone or mixed with silymarin at 40 mg/100 g for additional 6 weeks. Biochemical analysis was used to test the serum lipid and bile acid profiles. Farnesyl X receptor (FXR) and nuclear factor kappa B (NF-κB) transactivities were analyzed in liver using a gene reporter assay based on quantitative RT-PCR. Silymarin treatment ameliorated insulin resistance, dyslipidaemia and inflammation, and reconstituted the...
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abstractSilymarin, a standardized extract of the milk thistle seeds, has been widely used to treat chronic hepatitis, cirrhosis, and other types of toxic liver damage. Despite increasing studies on the action of silymarin and its major active constituent, silybin in their therapeutic properties against insulin resistance, diabetes and hyperlipidaemia and , the mechanism underlying silymarin action remains unclear. C57BL/6 mice were fed high-fat diet (HFD) for 3 months to induce obesity, insulin resistance, hyperlipidaemia, and fatty liver. These mice were then continuously treated with HFD alone or mixed with silymarin at 40 mg/100 g for additional 6 weeks. Biochemical analysis was used to test the serum lipid and bile acid profiles. Farnesyl X receptor (FXR) and nuclear factor kappa B (NF-κB) transactivities were analyzed in liver using a gene reporter assay based on quantitative RT-PCR. Silymarin treatment ameliorated insulin resistance, dyslipidaemia and inflammation, and reconstituted the...
pmid27733832